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Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation

P. Prochazkova, R. Roubalova, J. Dvorak, H. Tlaskalova-Hogenova, M. Cermakova, P. Tomasova, B. Sediva, M. Kuzma, J. Bulant, M. Bilej, P. Hrabak, E. Meisnerova, A. Lambertova, H. Papezova,

. 2019 ; 7 (9) : . [pub] 20190910

Jazyk angličtina Země Švýcarsko

Typ dokumentu kazuistiky

Perzistentní odkaz   https://www.medvik.cz/link/bmc19035698

Grantová podpora
17-28905A MINISTRY OF HEALTH OF THE CZECH REPUBLIC

The change in the gut microbiome and microbial metabolites in a patient suffering from severe and enduring anorexia nervosa (AN) and diagnosed with small intestinal bacterial overgrowth syndrome (SIBO) was investigated. Microbial gut dysbiosis is associated with both AN and SIBO, and therefore gut microbiome changes by serial fecal microbiota transplantation (FMT) is a possible therapeutic modality. This study assessed the effects of FMT on gut barrier function, microbiota composition, and the levels of bacterial metabolic products. The patient treatment with FMT led to the improvement of gut barrier function, which was altered prior to FMT. Very low bacterial alpha diversity, a lack of beneficial bacteria, together with a great abundance of fungal species were observed in the patient stool sample before FMT. After FMT, both bacterial species richness and gut microbiome evenness increased in the patient, while the fungal alpha diversity decreased. The total short-chain fatty acids (SCFAs) levels (molecules presenting an important source of energy for epithelial gut cells) gradually increased after FMT. Contrarily, one of the most abundant intestinal neurotransmitters, serotonin, tended to decrease throughout the observation period. Overall, gut microbial dysbiosis improvement after FMT was considered. However, there were no signs of patient clinical improvement. The need for an in-depth analysis of the donor´s stool and correct selection pre-FMT is evident.

Citace poskytuje Crossref.org

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$a Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation / $c P. Prochazkova, R. Roubalova, J. Dvorak, H. Tlaskalova-Hogenova, M. Cermakova, P. Tomasova, B. Sediva, M. Kuzma, J. Bulant, M. Bilej, P. Hrabak, E. Meisnerova, A. Lambertova, H. Papezova,
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$a The change in the gut microbiome and microbial metabolites in a patient suffering from severe and enduring anorexia nervosa (AN) and diagnosed with small intestinal bacterial overgrowth syndrome (SIBO) was investigated. Microbial gut dysbiosis is associated with both AN and SIBO, and therefore gut microbiome changes by serial fecal microbiota transplantation (FMT) is a possible therapeutic modality. This study assessed the effects of FMT on gut barrier function, microbiota composition, and the levels of bacterial metabolic products. The patient treatment with FMT led to the improvement of gut barrier function, which was altered prior to FMT. Very low bacterial alpha diversity, a lack of beneficial bacteria, together with a great abundance of fungal species were observed in the patient stool sample before FMT. After FMT, both bacterial species richness and gut microbiome evenness increased in the patient, while the fungal alpha diversity decreased. The total short-chain fatty acids (SCFAs) levels (molecules presenting an important source of energy for epithelial gut cells) gradually increased after FMT. Contrarily, one of the most abundant intestinal neurotransmitters, serotonin, tended to decrease throughout the observation period. Overall, gut microbial dysbiosis improvement after FMT was considered. However, there were no signs of patient clinical improvement. The need for an in-depth analysis of the donor´s stool and correct selection pre-FMT is evident.
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$a Roubalova, Radka $u Laboratory of Cellular and Molecular Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 1083 Videnska, Prague 4, Czech Republic. r.roubalova@biomed.cas.cz.
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$a Dvorak, Jiri $u Laboratory of Cellular and Molecular Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 1083 Videnska, Prague 4, Czech Republic. dvorak@biomed.cas.cz.
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$a Tlaskalova-Hogenova, Helena $u Laboratory of Cellular and Molecular Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 1083 Videnska, Prague 4, Czech Republic. tlaskalo@biomed.cas.cz.
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$a Cermakova, Martina $u Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 1083 Videnska, Prague 4, Czech Republic. martina.buganova@biomed.cas.cz. Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague 6, Czech Republic. martina.buganova@biomed.cas.cz.
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$a Tomasova, Petra $u Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 1083 Videnska, Prague 4, Czech Republic. petra.tomasova@biomed.cas.cz. th Medical Department, First Faculty of Medicine, Charles University and General Faculty Hospital in Prague, U Nemocnice 2, 128 08 Praha 2, Czech Republic. petra.tomasova@biomed.cas.cz.
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$a Sediva, Blanka $u Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 1083 Videnska, Prague 4, Czech Republic. sediva@kma.zcu.cz. Faculty of Applied Sciences, University of West Bohemia, Univerzitni 8, 306 14 Plzen, Czech Republic. sediva@kma.zcu.cz.
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$a Kuzma, Marek $u Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 1083 Videnska, Prague 4, Czech Republic. kuzma@biomed.cas.cz.
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$a Bulant, Josef $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, Prague 2, Czech Republic. josef.bulant@gmail.com.
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$a Bilej, Martin $u Laboratory of Cellular and Molecular Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 1083 Videnska, Prague 4, Czech Republic. mbilej@biomed.cas.cz.
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$a Hrabak, Pavel $u Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, Prague 2, Czech Republic. Pavel.Hrabak@vfn.cz.
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$a Meisnerova, Eva $u Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, Prague 2, Czech Republic. Eva.Meisnerova@vfn.cz.
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$a Lambertova, Alena $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, Prague 2, Czech Republic. Alena.Lambertova@vfn.cz.
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$a Papezova, Hana $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 11, Prague 2, Czech Republic. Hana.Papezova@vfn.cz.
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