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Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy
Ondrej Klempir, Radim Krupicka, Jan Mehnert, Vaclav Cejka, Kamila Polakova, Hana Brozova, Zoltan Szabo, Evzen Ruzicka, Robert Jech
Jazyk angličtina Země Česko
Typ dokumentu práce podpořená grantem
- MeSH
- blízká infračervená spektroskopie * normy MeSH
- chůze MeSH
- hemoglobiny MeSH
- hluboká mozková stimulace * MeSH
- lidé MeSH
- mapování mozku MeSH
- motorické korové centrum * diagnostické zobrazování MeSH
- nemoci mozku diagnostické zobrazování MeSH
- neurozobrazování metody MeSH
- nucleus subthalamicus MeSH
- Parkinsonova nemoc * diagnostické zobrazování diagnóza patofyziologie terapie MeSH
- počítačové zpracování signálu MeSH
- pohybová aktivita * MeSH
- prsty ruky MeSH
- výzkum MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
Exploration of motor cortex activity is essential to understanding the pathophysiology in Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or PET. We aim to investigate the cortical activity of PD patients during a complex motor task (gait) to verify the impact of deep brain stimulation in the subthalamic nucleus (DBS-STN) by using Near-Infrared-Spectroscopy (NIRS). NIRS is a neuroimaging method of brain cortical activity using low-energy optical radiation to detect local changes in (de)oxyhemoglobin concentration. We used a multichannel portable NIRS during finger tapping (FT) and gait. To determine the signal activity, our methodology consisted of a pre-processing phase for the raw signal, followed by statistical analysis based on a general linear model. Processed recordings from 9 patients were statistically compared between the on and off states of DBS-STN. DBS-STN led to an increased activity in the contralateral motor cortex areas during FT. During gait, we observed a concentration of activity towards the cortex central area in the "stimulation-on" state. Our study shows how NIRS can be used to detect functional changes in the cortex of patients with PD with DBS-STN and indicates its future use for applications unsuited for PET and a fMRI.
Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany
University Medical Center Eppendorf Department of Systems Neuroscience Hamburg Germany
Citace poskytuje Crossref.org
Literatura
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- $a Exploration of motor cortex activity is essential to understanding the pathophysiology in Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or PET. We aim to investigate the cortical activity of PD patients during a complex motor task (gait) to verify the impact of deep brain stimulation in the subthalamic nucleus (DBS-STN) by using Near-Infrared-Spectroscopy (NIRS). NIRS is a neuroimaging method of brain cortical activity using low-energy optical radiation to detect local changes in (de)oxyhemoglobin concentration. We used a multichannel portable NIRS during finger tapping (FT) and gait. To determine the signal activity, our methodology consisted of a pre-processing phase for the raw signal, followed by statistical analysis based on a general linear model. Processed recordings from 9 patients were statistically compared between the on and off states of DBS-STN. DBS-STN led to an increased activity in the contralateral motor cortex areas during FT. During gait, we observed a concentration of activity towards the cortex central area in the "stimulation-on" state. Our study shows how NIRS can be used to detect functional changes in the cortex of patients with PD with DBS-STN and indicates its future use for applications unsuited for PET and a fMRI.
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