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Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes
L. Din, M. Sheikh, N. Kosaraju, KE. Smedby, S. Bernatsky, SI. Berndt, CF. Skibola, A. Nieters, S. Wang, JD. McKay, P. Cocco, M. Maynadié, L. Foretová, A. Staines, TM. Mack, S. de Sanjosé, TJ. Vyse, L. Padyukov, A. Monnereau, AA. Arslan, A. Moore,...
Language English Country United States
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
Grant support
P50 CA97274
James R Cerhan is supported by NIH grants - International
RC4 AG039029
NIA NIH HHS - United States
NIH R01CA134674
Nicola Camp reports support from - International
HHSN268201100001I
NHLBI NIH HHS - United States
CA62006
NCI NIH HHS - United States
P30 CA016087
NCI NIH HHS - United States
HHSN261201000140C
NCI NIH HHS - United States
N01 PC067010
NCI NIH HHS - United States
U01 HG004446
NHGRI NIH HHS - United States
R01 CA098122
NCI NIH HHS - United States
U01 HG007033
NHGRI NIH HHS - United States
U01 CA195568
NCI NIH HHS - United States
R01 CA133996
NCI NIH HHS - United States
NS19142
NIH HHS - United States
P30 CA42014
Partial support for all datasets within the UPDB is provided by the Huntsman Cancer Institute (HCI) and the HCI Comprehensive Cancer Center Support grant - International
P50 CA097007
NCI NIH HHS - United States
R01CA201407
David Conti is supported by the following NIH - International
U01 AG009740
NIA NIH HHS - United States
P01 CA087969
NCI NIH HHS - United States
R01 NS049477
NINDS NIH HHS - United States
R01 CA134958
NCI NIH HHS - United States
5R01 CA69669-02
Strategic Research Program in Epidemiology at Karolinska Institute and National Institutes of Health - International
HHSN261201000006C
NCI NIH HHS - United States
HHSN268201100004I
NHLBI NIH HHS - United States
AI076544
NIH HHS - United States
NS049477
NIH HHS - United States
CA87969
NIH HHS - United States
075491/Z/04/Z, and 068545/Z/02
Wellcome Trust - United Kingdom
HHSN268201100046C
NHLBI NIH HHS - United States
NO1-CO-12400
NIH HHS - United States
P30 CA086862
NCI NIH HHS - United States
U01 CA167552
NCI NIH HHS - United States
CA149445
NIH HHS - United States
R01 ES011740
NIEHS NIH HHS - United States
R01CA134674
NIH HHS - United States
CA118444
NIH HHS - United States
R01 CA92153
James R Cerhan is supported by NIH grants - International
R01 AI076544
NIAID NIH HHS - United States
N01 PC067008
NCI NIH HHS - United States
RR020092
NIH HHS - United States
HHSN268201100003C
WHI NIH HHS - United States
R01 CA148690
NCI NIH HHS - United States
P30 ES000260
NIEHS NIH HHS - United States
R01 NS067305
NINDS NIH HHS - United States
UL1 RR024992
NCRR NIH HHS - United States
C06 RR020092
NCRR NIH HHS - United States
R01 CA104021
NCI NIH HHS - United States
R01 ES016813
NIEHS NIH HHS - United States
K08CA134919
NIH HHS - United States
R01 CA140561
NCI NIH HHS - United States
CA186107
NIH HHS - United States
CA104021
NIH HHS - United States
R01 CA129539
NCI NIH HHS - United States
R01 CA122663
NCI NIH HHS - United States
R03 CA150037
NCI NIH HHS - United States
U58 DP000807
NCCDPHP CDC HHS - United States
CA49449
NIH HHS - United States
RR024992 and K23N/S048869
NIH HHS - United States
R37HL039693
NIH/NHLBI - International
R01 CA154643
NCI NIH HHS - United States
P30 CA15083
NCI NIH HHS - United States
R01 CA062006
NCI NIH HHS - United States
N01 PC065064
NCI NIH HHS - United States
K08 CA134919
NCI NIH HHS - United States
UL1 TR000135
NCATS NIH HHS - United States
HHSN271201100004C
NIA NIH HHS - United States
CA92153
NIH HHS - United States
NS049510
NIH HHS - United States
R01 CA201407
NCI NIH HHS - United States
P01CA196569
David Conti is supported by the following NIH - International
R01 CA098661
NCI NIH HHS - United States
R01 NS049510
NINDS NIH HHS - United States
UM1 CA186107
NCI NIH HHS - United States
HHSN268201100002C
WHI NIH HHS - United States
P30 CA015083
NCI NIH HHS - United States
R01 CA092153
NCI NIH HHS - United States
CA148690
NIH HHS - United States
HHSN261201000035I
NCI NIH HHS - United States
CA098122, and CA134958
NIH HHS - United States
HHSN261201000035C
NCI NIH HHS - United States
HHSN261201000034C
NCI NIH HHS - United States
NS43559
NIH HHS - United States
CIBERESP
Spanish Ministry of Economy and Competitiveness-Carlos III Institute of Health cofunded by FEDER funds/European Regional Develpment Fund (ERDF)-a way to build Europe - International
HHSN268201100004C, and HHSN271201100004C
National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts - International
5P30CA014089
David Conti is supported by the following NIH - International
UM1 CA167552
NCI NIH HHS - United States
N01RC37004
CCR NIH HHS - United States
R01 CA087014
NCI NIH HHS - United States
R37 HL039693
NHLBI NIH HHS - United States
CA97274
NIH HHS - United States
ES000260
NIEHS NIH HHS - United States
085475/B/08/Z
Wellcome Trust - United Kingdom
P50 CA097274
NCI NIH HHS - United States
RC2 AG036495
NIA NIH HHS - United States
Wellcome Trust - United Kingdom
R01 NS032830
NINDS NIH HHS - United States
R01 CA049449
NCI NIH HHS - United States
HHSN268201100002I
NHLBI NIH HHS - United States
NS26799
NIH HHS - United States
R21 ES024844
NIEHS NIH HHS - United States
R01 CA200703
NCI NIH HHS - United States
N01CO12400
NCI NIH HHS - United States
085475/Z/08/Z
Wellcome Trust - United Kingdom
R01 NS026799
NINDS NIH HHS - United States
R01 NS043559
NINDS NIH HHS - United States
U01 CA049449
NCI NIH HHS - United States
R01 CA149445
NCI NIH HHS - United States
P01 CA196569
NCI NIH HHS - United States
R01 CA134674
NCI NIH HHS - United States
NS067305
NIH HHS - United States
P50 CA093459
NCI NIH HHS - United States
UL1 TR002345
NCATS NIH HHS - United States
R01 CA045614
NCI NIH HHS - United States
HHSN261201000026C
NCI NIH HHS - United States
R01CA206019
David Conti is supported by the following NIH - International
HHSN268201100001C
WHI NIH HHS - United States
HHSN268201100004C
WHI NIH HHS - United States
U01 CA118444
NCI NIH HHS - United States
P30 CA042014
NCI NIH HHS - United States
NS032830
NIH HHS - United States
PubMed
31407831
DOI
10.1002/gepi.22242
Knihovny.cz E-resources
- MeSH
- Alleles MeSH
- Autoimmune Diseases genetics MeSH
- Genetic Predisposition to Disease * MeSH
- HLA Antigens genetics MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Multifactorial Inheritance genetics MeSH
- Lymphoma, Non-Hodgkin genetics MeSH
- Risk Factors MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
Behavioral and Epidemiology Research Group American Cancer Society Atlanta Georgia
California State University Sacramento Califonia
Cancer Epidemiology Unit University of Oxford Oxford England
Centre de Recherche en Cancerologie de Lyon Lyon France
Centre for Big Data Research in Health University of New South Wales Kensington Australia
Centre of Chronic Immunodeficiency University Medical Centre Freiburg Freiburg im Breisgau Germany
College of Medicine California Northstate University Elk Grove California
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Environmental Epidemiology of Cancers INSERM Paris France
Department of Environmental Health Sciences Yale School of Public Health New Haven Connecticut
Department of Epidemiology Research Statens Serum Institut København Denmark
Department of Family Medicine and Public Health Sciences Wayne State University Detroit Michigan
Department of Health Sciences Research Mayo Clinic Rochester Minnesota
Department of Health Sciences University of York York England
Department of Immunology Genetics and Pathology Uppsala Universitet Uppsala Sweden
Department of Internal Medicine Mayo Clinic Rochester Minnesota
Department of Medical and Molecular Genetics King's College London London England
Department of Medical Sciences and Public Health University of Cagliari Cagliari Sardinia Italy
Department of Medicine Universita degli Studi di Perugia Perugia Italy
Department of Neurology University of California San Francisco California
Department of Pediatrics University of Chicago Chicago Illinois
Department of Population Sciences City of Hope and the Beckman Research Institute Duarte California
Department of Preventive Medicine University of Southern California Los Angeles Califonia
Departments of Epidemiology and Biostatistics Harvard School of Public Health Boston Massachusetts
Division of Cancer Biology National Cancer Institute Bethesda Maryland
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland
Division of Cancer Epidemiology Deutsches Krebsforschungszentrum Heidelberg Germany
Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany
Division of Clinical Epidemiology Department of Medicine Karolinska Institutet Solna Sweden
Division of Rheumatology Department of Medicine Karolinska Institutet Stockholm Sweden
Hematology Department Centre Hospitalier Universitaire de Lyon Lyon France
Internal Medicine University of Iowa Hospitals and Clinics Iowa City Iowa
International Agency for Research on Cancer Lyon France
Lymphoid Malignancies Unit Henri Mondor Hospital University Paris Est Créteil Paris France
Medicina Traslazionale Università del Piemonte Orientale Vercelli Italy
Memorial Sloan Kettering Cancer Center New York New York
School of Biomedical Sciences University of Calgary Calgary Canada
School of Medicine Emory University Atlanta Georgia
School of Nursing and Human Science Dublin City University Dublin Ireland
School of Public Health Brown University Providence Rhode Island
School of Public Health Imperial College London London England
Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York New York
References provided by Crossref.org
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- 650 _2
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- 655 _2
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- 700 1_
- $a Sheikh, Mohammad $u College of Medicine, California Northstate University, Elk Grove, California.
- 700 1_
- $a Kosaraju, Nikitha $u Center for Neuroengineering and Therapeutics, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
- 700 1_
- $a Smedby, Karin Ekstrom $u Division of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Solna, Sweden.
- 700 1_
- $a Bernatsky, Sasha $u Faculty of Medicine, McGill University, Montreal, Canada. Clinical Epidemiology, McGill University Health Centre, Research Institute, Montreal, Canada.
- 700 1_
- $a Berndt, Sonja I $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
- 700 1_
- $a Skibola, Christine F $u School of Medicine, Emory University, Atlanta, Georgia.
- 700 1_
- $a Nieters, Alexandra $u Centre of Chronic Immunodeficiency, University Medical Centre Freiburg, Freiburg im Breisgau, Germany.
- 700 1_
- $a Wang, Sophia $u Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, California.
- 700 1_
- $a McKay, James D $u International Agency for Research on Cancer, Lyon, France.
- 700 1_
- $a Cocco, Pierluigi $u Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Sardinia, Italy.
- 700 1_
- $a Maynadié, Marc $u The University of Burgundy-Franche-Comté and CHU Dijon Bourgogne, Registre des Hémopathies Malignes de Côte d'Or, INSERM U1231, Dijon, France.
- 700 1_
- $a Foretová, Lenka $u Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
- 700 1_
- $a Staines, Anthony $u School of Nursing and Human Science, Dublin City University, Dublin, Ireland.
- 700 1_
- $a Mack, Thomas M $u Norris Comprehensive Cancer Center and Hospital, University of Southern California, Los Angeles, California.
- 700 1_
- $a de Sanjosé, Silvia $u Reproductive Health Global Program PATH, School of Public Health, University of Washington, Seattle, Washington, USA. Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Institut Català d' Oncologia, (IDIBELL), Barcelona, Spain. Centro de Investigación Biomédica en Red, Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
- 700 1_
- $a Vyse, Timothy J $u Department of Medical and Molecular Genetics, King's College London, London, England.
- 700 1_
- $a Padyukov, Leonid $u Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Monnereau, Alain $u Center of Research in Epidemiology and Statistics, Sorbonne (CRESS), Epidemiology of Childhood and Adolescent Cancer Group, INSERM, Paris, France. Registre des Hémopathies Malignes de la Gironde, Institut Bergonie, Bordeaux, France.
- 700 1_
- $a Arslan, Alan A $u Department of Obstetrics and Gynecology, Department of Population Health, Department of Environmental Medicine, NYU School of Medicine, New York, New York.
- 700 1_
- $a Moore, Amy $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
- 700 1_
- $a Brooks-Wilson, Angela R $u Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
- 700 1_
- $a Novak, Anne J $u Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
- 700 1_
- $a Glimelius, Bengt $u Department of Immunology, Genetics, and Pathology, Uppsala Universitet, Uppsala, Sweden.
- 700 1_
- $a Birmann, Brenda M $u Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
- 700 1_
- $a Link, Brian K $u Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
- 700 1_
- $a Stewart, Carolyn $u Memorial Sloan Kettering Cancer Center, New York, New York.
- 700 1_
- $a Vajdic, Claire M $u Centre for Big Data Research in Health, University of New South Wales, Kensington, Australia.
- 700 1_
- $a Haioun, Corinne $u Lymphoid Malignancies Unit, Henri Mondor Hospital, University Paris-Est Créteil (UPEC), Paris, France.
- 700 1_
- $a Magnani, Corrado $u Medicina Traslazionale, Università del Piemonte Orientale, Vercelli, Italy.
- 700 1_
- $a Conti, David V $u Department of Preventive Medicine, University of Southern California, Los Angeles, Califonia.
- 700 1_
- $a Cox, David G $u Centre de Recherche en Cancerologie de Lyon, Lyon, France.
- 700 1_
- $a Casabonne, Delphine $u Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Institut Català d' Oncologia, (IDIBELL), Barcelona, Spain. Centro de Investigación Biomédica en Red, Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
- 700 1_
- $a Albanes, Demetrius $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
- 700 1_
- $a Kane, Eleanor $u Department of Health Sciences, University of York, York, England.
- 700 1_
- $a Roman, Eve $u Department of Health Sciences, University of York, York, England.
- 700 1_
- $a Muzi, Giacomo $u Department of Medicine, Universita degli Studi di Perugia, Perugia, Italy.
- 700 1_
- $a Salles, Gilles $u Hematology Department, Centre Hospitalier Universitaire de Lyon, Lyon, France.
- 700 1_
- $a Giles, Graham G $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia. Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Australia.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Pradhan, Nisha $u Memorial Sloan Kettering Cancer Center, New York, New York.
- 700 1_
- $a Bracci, Paige M $u Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
- 700 1_
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- 700 1_
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- 700 1_
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