PURPOSE: The aim of this neurophysiological study was to monitor changes in the visual and cognitive function of HIV-infected patients treated with combination antiretroviral therapy. METHODS: Eleven adult Czech HIV+ patients, with a mean age of 35 years and CD4 cell count ≥ 230 × 106 cells/L of blood at the time of enrollment, underwent four to six examinations over the course of 2.5 years to evaluate pattern-reversal and motion-onset visual evoked potentials (P-VEPs and M-VEPs), visually driven oddball event-related potentials (ERPs) and Montreal Cognitive Assessments. In addition to evaluating the intraindividual change in the observed parameters, we also compared patient data to data from eleven age- and gender-matched controls. RESULTS: We did not find any significant differences in P-VEPs between the patients and controls or in the paired comparison of the first and last visit. The only significant finding for P-VEPs was a linear trend in prolongation of the 20' P-VEP P100 peak time. In M-VEPs, we found a significant intergroup difference in the N160 peak time recorded during the first visit for peripheral M-VEPs only. During the last visit, all N160 peak times for patients differed significantly from those of the control group. The only intervisit difference close to the level of significance was for peripheral M-VEPs, which confirmed the trend analysis. No significant differences between patients and controls were found in the ERPs, but the P300 peak time showed a significant difference between the first and last visits, as confirmed by the trend. Patient reaction time was not significantly delayed at the first visit; however, it was prolonged with time, as confirmed by the trend. CONCLUSION: Our aim was to evaluate whether antiretroviral treatment in HIV+ patients is sufficient to preserve brain visual function. The optic nerve and primary visual cortex function tested by the P-VEPs seem to be preserved. The prolongation of the M-VEPs suggests an individually detectable decline in CNS function, but these changes did not show a progression during the follow-up. From a longitudinal perspective, the trends in peak time prolongation of the 20' P-VEP, peripheral M-VEP, ERP and reaction time suggest a faster decline than that caused by aging in healthy populations, as previously described in a cross-sectional study.

Department of Infectious Diseases Faculty Hospital in Hradec Kralove Hradec Kralove Czech Republic

Department of Infectious Diseases Faculty Hospital in Hradec Kralove Hradec Kralove Czech Republic Department of Epidemiology Faculty of Military Health Sciences University of Defence in Hradec Kralove Hradec Kralove Czech Republic

Department of Pathological Physiology Charles University Faculty of Medicine in Hradec Kralove Simkova 870 500 03 Hradec Kralove Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc19044876

003      

CZ-PrNML

005      

20200113144508.0

007      

ta

008      

200109s2019 ne f 000 0|eng||

009      

AR

024    7_

$a 10.1007/s10633-019-09697-4 $2 doi

035    __

$a (PubMed)30993574

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a ne

100    1_

$a Szanyi, Jana $u Department of Pathological Physiology, Charles University - Faculty of Medicine in Hradec Kralove, Simkova 870, 500 03, Hradec Kralove, Czech Republic. szanyi@lfhk.cuni.cz.

245    10

$a Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years / $c J. Szanyi, J. Kremlacek, Z. Kubova, M. Kuba, P. Gebousky, J. Kapla, J. Szanyi, F. Vit, J. Langrova,

520    9_

$a PURPOSE: The aim of this neurophysiological study was to monitor changes in the visual and cognitive function of HIV-infected patients treated with combination antiretroviral therapy. METHODS: Eleven adult Czech HIV+ patients, with a mean age of 35 years and CD4 cell count ≥ 230 × 106 cells/L of blood at the time of enrollment, underwent four to six examinations over the course of 2.5 years to evaluate pattern-reversal and motion-onset visual evoked potentials (P-VEPs and M-VEPs), visually driven oddball event-related potentials (ERPs) and Montreal Cognitive Assessments. In addition to evaluating the intraindividual change in the observed parameters, we also compared patient data to data from eleven age- and gender-matched controls. RESULTS: We did not find any significant differences in P-VEPs between the patients and controls or in the paired comparison of the first and last visit. The only significant finding for P-VEPs was a linear trend in prolongation of the 20' P-VEP P100 peak time. In M-VEPs, we found a significant intergroup difference in the N160 peak time recorded during the first visit for peripheral M-VEPs only. During the last visit, all N160 peak times for patients differed significantly from those of the control group. The only intervisit difference close to the level of significance was for peripheral M-VEPs, which confirmed the trend analysis. No significant differences between patients and controls were found in the ERPs, but the P300 peak time showed a significant difference between the first and last visits, as confirmed by the trend. Patient reaction time was not significantly delayed at the first visit; however, it was prolonged with time, as confirmed by the trend. CONCLUSION: Our aim was to evaluate whether antiretroviral treatment in HIV+ patients is sufficient to preserve brain visual function. The optic nerve and primary visual cortex function tested by the P-VEPs seem to be preserved. The prolongation of the M-VEPs suggests an individually detectable decline in CNS function, but these changes did not show a progression during the follow-up. From a longitudinal perspective, the trends in peak time prolongation of the 20' P-VEP, peripheral M-VEP, ERP and reaction time suggest a faster decline than that caused by aging in healthy populations, as previously described in a cross-sectional study.

650    _2

$a dospělí $7 D000328

650    _2

$a antiretrovirové látky $x terapeutické užití $7 D044966

650    _2

$a počet CD4 lymfocytů $7 D018791

650    _2

$a kognice $x fyziologie $7 D003071

650    _2

$a průřezové studie $7 D003430

650    _2

$a elektroretinografie $7 D004596

650    _2

$a evokované potenciály $x fyziologie $7 D005071

650    _2

$a zrakové evokované potenciály $x fyziologie $7 D005074

650    _2

$a ženské pohlaví $7 D005260

650    _2

$a HIV infekce $x farmakoterapie $x patofyziologie $7 D015658

650    _2

$a lidé $7 D006801

650    _2

$a longitudinální studie $7 D008137

650    _2

$a mužské pohlaví $7 D008297

650    _2

$a lidé středního věku $7 D008875

650    _2

$a vnímání pohybu $x fyziologie $7 D009039

650    _2

$a reakční čas $x fyziologie $7 D011930

650    _2

$a zraková ostrost $x fyziologie $7 D014792

650    _2

$a zrakové korové centrum $x fyziologie $7 D014793

650    _2

$a mladý dospělý $7 D055815

655    _2

$a časopisecké články $7 D016428

655    _2

$a práce podpořená grantem $7 D013485

700    1_

$a Kremlacek, Jan $u Department of Pathological Physiology, Charles University - Faculty of Medicine in Hradec Kralove, Simkova 870, 500 03, Hradec Kralove, Czech Republic.

700    1_

$a Kubova, Zuzana $u Department of Pathological Physiology, Charles University - Faculty of Medicine in Hradec Kralove, Simkova 870, 500 03, Hradec Kralove, Czech Republic.

700    1_

$a Kuba, Miroslav $u Department of Pathological Physiology, Charles University - Faculty of Medicine in Hradec Kralove, Simkova 870, 500 03, Hradec Kralove, Czech Republic.

700    1_

$a Gebousky, Pavel $u Department of Infectious Diseases, Faculty Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.

700    1_

$a Kapla, Jaroslav $u Department of Infectious Diseases, Faculty Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.

700    1_

$a Szanyi, Juraj $u Department of Infectious Diseases, Faculty Hospital in Hradec Kralove, Hradec Kralove, Czech Republic. Department of Epidemiology, Faculty of Military Health Sciences, University of Defence in Hradec Kralove, Hradec Kralove, Czech Republic.

700    1_

$a Vit, Frantisek $u Department of Pathological Physiology, Charles University - Faculty of Medicine in Hradec Kralove, Simkova 870, 500 03, Hradec Kralove, Czech Republic.

700    1_

$a Langrova, Jana $u Department of Pathological Physiology, Charles University - Faculty of Medicine in Hradec Kralove, Simkova 870, 500 03, Hradec Kralove, Czech Republic.

773    0_

$w MED00010453 $t Documenta ophthalmologica. Advances in ophthalmology $x 1573-2622 $g Roč. 139, č. 2 (2019), s. 83-97

856    41

$u https://pubmed.ncbi.nlm.nih.gov/30993574 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y a $z 0

990    __

$a 20200109 $b ABA008

991    __

$a 20200113144840 $b ABA008

999    __

$a ok $b bmc $g 1483145 $s 1083549

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2019 $b 139 $c 2 $d 83-97 $e 20190416 $i 1573-2622 $m Documenta ophthalmologica $n Doc Ophthalmol $x MED00010453

LZP    __

$a Pubmed-20200109