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Tracking of Borrelia afzelii Transmission from Infected Ixodes ricinus Nymphs to Mice
T. Pospisilova, V. Urbanova, O. Hes, P. Kopacek, O. Hajdusek, R. Sima,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1970 to 6 months ago
Freely Accessible Science Journals
from 1995 to 6 months ago
PubMed Central
from 1970 to 6 months ago
Europe PubMed Central
from 1970 to 6 months ago
Open Access Digital Library
from 1970-01-01
Open Access Digital Library
from 1970-01-01
PubMed
30910791
DOI
10.1128/iai.00896-18
Knihovny.cz E-resources
- MeSH
- Arachnid Vectors microbiology physiology MeSH
- Borrelia burgdorferi Group physiology MeSH
- Ixodes microbiology physiology MeSH
- Humans MeSH
- Lyme Disease microbiology transmission MeSH
- Mice, Inbred C3H MeSH
- Mice MeSH
- Nymph microbiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Quantitative and microscopic tracking of Borrelia afzelii transmission from infected Ixodes ricinus nymphs has shown a transmission cycle different from that of Borrelia burgdorferi and Ixodes scapularisBorrelia afzelii organisms are abundant in the guts of unfed I. ricinus nymphs, and their numbers continuously decrease during feeding. Borrelia afzelii spirochetes are present in murine skin within 1 day of tick attachment. In contrast, spirochetes were not detectable in salivary glands at any stage of tick feeding. Further experiments demonstrated that tick saliva is not essential for B. afzelii infectivity, the most important requirement for successful host colonization being a change in expression of outer surface proteins that occurs in the tick gut during feeding. Spirochetes in vertebrate mode are then able to survive within the host even in the absence of tick saliva. Taken together, our data suggest that the tick gut is the decisive organ that determines the competence of I. ricinus to vector B. afzelii We discuss possible transmission mechanisms of B. afzelii spirochetes that should be further tested in order to design effective preventive and therapeutic strategies against Lyme disease.
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