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Tracking of Borrelia afzelii Transmission from Infected Ixodes ricinus Nymphs to Mice
T. Pospisilova, V. Urbanova, O. Hes, P. Kopacek, O. Hajdusek, R. Sima,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1970 do Před 6 měsíci
Freely Accessible Science Journals
od 1995 do Před 6 měsíci
PubMed Central
od 1970 do Před 6 měsíci
Europe PubMed Central
od 1970 do Před 6 měsíci
Open Access Digital Library
od 1970-01-01
Open Access Digital Library
od 1970-01-01
PubMed
30910791
DOI
10.1128/iai.00896-18
Knihovny.cz E-zdroje
- MeSH
- arachnida jako vektory mikrobiologie fyziologie MeSH
- Borrelia burgdorferi komplex fyziologie MeSH
- klíště mikrobiologie fyziologie MeSH
- lidé MeSH
- lymeská nemoc mikrobiologie přenos MeSH
- myši inbrední C3H MeSH
- myši MeSH
- nymfa mikrobiologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Quantitative and microscopic tracking of Borrelia afzelii transmission from infected Ixodes ricinus nymphs has shown a transmission cycle different from that of Borrelia burgdorferi and Ixodes scapularisBorrelia afzelii organisms are abundant in the guts of unfed I. ricinus nymphs, and their numbers continuously decrease during feeding. Borrelia afzelii spirochetes are present in murine skin within 1 day of tick attachment. In contrast, spirochetes were not detectable in salivary glands at any stage of tick feeding. Further experiments demonstrated that tick saliva is not essential for B. afzelii infectivity, the most important requirement for successful host colonization being a change in expression of outer surface proteins that occurs in the tick gut during feeding. Spirochetes in vertebrate mode are then able to survive within the host even in the absence of tick saliva. Taken together, our data suggest that the tick gut is the decisive organ that determines the competence of I. ricinus to vector B. afzelii We discuss possible transmission mechanisms of B. afzelii spirochetes that should be further tested in order to design effective preventive and therapeutic strategies against Lyme disease.
Citace poskytuje Crossref.org
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