• Je něco špatně v tomto záznamu ?

Long-term peritoneal dialysis treatment provokes activation of genes related to adaptive immunity

A. Parikova, P. Hruba, R. T. Krediet, Z. Krejcik, V. Stranecky, I. Striz, O. Viklicky

. 2019 ; 68 (5) : 775-783. [pub] 20190819

Jazyk angličtina Země Česko

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005494

Grantová podpora
NV15-26638A MZ0 CEP - Centrální evidence projektů

Permanent irritation of the peritoneum during peritoneal dialysis (PD) treatment leads to local chronic inflammation and subsequently activation of processes driving fibrogenesis in the long-term. The aim of the study was to compare the peritoneal effluent transcriptome of 20 patients treated less and 13 patients treated more than 2 years using microarray analysis. An increased expression of genes associated with an immune response was observed in long-term treated patients with well preserved peritoneal function, when compared to patients treated less than 2 years. From 100 genes highly expressed in long-term patients, a significant up-regulation of six was found by RT-qPCR: LY9 (lymphocyte antigen 9), TNSFR4 (tumor necrosis factor receptor superfamily, member 4), CD 79A (CD79a molecule), CCR7 (chemokine C-C receptor 7), CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) and IL2RA (interleukin 2 receptor alpha chain). Furthermore, the effluent cell population was analysed. A positive relationship between the number of granulocytes and NK cells on one hand, and duration of PD treatment on the other, was shown. We conclude, that the mechanisms of adaptive immunity promoting T helper 2 cells response are activated in the long-term before functional alterations develop. It consequently might trigger the fibrosis promoting processes.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc20005494
003      
CZ-PrNML
005      
20201016093303.0
007      
ta
008      
200511s2019 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934158 $2 doi
035    __
$a (PubMed)31424258
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Paříková, Alena, $d 1974- $7 xx0091053 $u Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
245    10
$a Long-term peritoneal dialysis treatment provokes activation of genes related to adaptive immunity / $c A. Parikova, P. Hruba, R. T. Krediet, Z. Krejcik, V. Stranecky, I. Striz, O. Viklicky
504    __
$a Literatura
520    9_
$a Permanent irritation of the peritoneum during peritoneal dialysis (PD) treatment leads to local chronic inflammation and subsequently activation of processes driving fibrogenesis in the long-term. The aim of the study was to compare the peritoneal effluent transcriptome of 20 patients treated less and 13 patients treated more than 2 years using microarray analysis. An increased expression of genes associated with an immune response was observed in long-term treated patients with well preserved peritoneal function, when compared to patients treated less than 2 years. From 100 genes highly expressed in long-term patients, a significant up-regulation of six was found by RT-qPCR: LY9 (lymphocyte antigen 9), TNSFR4 (tumor necrosis factor receptor superfamily, member 4), CD 79A (CD79a molecule), CCR7 (chemokine C-C receptor 7), CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) and IL2RA (interleukin 2 receptor alpha chain). Furthermore, the effluent cell population was analysed. A positive relationship between the number of granulocytes and NK cells on one hand, and duration of PD treatment on the other, was shown. We conclude, that the mechanisms of adaptive immunity promoting T helper 2 cells response are activated in the long-term before functional alterations develop. It consequently might trigger the fibrosis promoting processes.
650    _2
$a adaptivní imunita $x genetika $7 D056704
650    _2
$a ascitická tekutina $x imunologie $x metabolismus $7 D001202
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a fibróza $7 D005355
650    _2
$a stanovení celkové genové exprese $7 D020869
650    _2
$a regulace genové exprese $7 D005786
650    _2
$a lidé $7 D006801
650    _2
$a nádory ledvin $x terapie $7 D007680
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a peritoneální dialýza $x škodlivé účinky $7 D010530
650    _2
$a kontinuální ambulantní peritoneální dialýza $x škodlivé účinky $7 D010531
650    _2
$a peritoneum $x imunologie $x metabolismus $x patologie $7 D010537
650    _2
$a časové faktory $7 D013997
650    _2
$a transkriptom $7 D059467
650    _2
$a výsledek terapie $7 D016896
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hrubá, Petra $7 xx0081967 $u Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Krediet, R. T. $u Department of Nephrology, Amsterdam UMC University of Amsterdam, Netherlands
700    1_
$a Krejčík, Zdeněk $7 xx0125786 $u Institute of Haematology and Blood Transfusion, Prague, Czech Republic
700    1_
$a Stránecký, Viktor $7 xx0128943 $u Institute of Inherited Metabolic Disorders, Prague, Czech Republic
700    1_
$a Stříž, Ilja, $d 1958- $7 jn20000402309 $u Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Viklický, Ondřej, $d 1966- $7 nlk20050170291 $u Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 68, č. 5 (2019), s. 775-783
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31424258 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20201016093300 $b ABA008
999    __
$a ok $b bmc $g 1528595 $s 1095549
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 68 $c 5 $d 775-783 $e 20190819 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
GRA    __
$a NV15-26638A $p MZ0
LZP    __
$b NLK118 $a Pubmed-20200511

Najít záznam

Citační ukazatele

    Možnosti archivace