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Intracerebroventricular endothelin receptor-A blockade in rats decreases phase-II ventricular tachyarrhythmias during acute myocardial infarction
P. Lekkas, E. S. Georgiou, M. Kontonika, E. T. Mouchtouri, I. Mourouzis, C. Pantos, T. M. Kolettis,
Language English Country Czech Republic
Document type Journal Article
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- MeSH
- Endothelin A Receptor Antagonists administration & dosage MeSH
- Peptides, Cyclic administration & dosage MeSH
- Myocardial Infarction drug therapy complications metabolism physiopathology MeSH
- Injections, Intraventricular MeSH
- Tachycardia, Ventricular etiology metabolism physiopathology prevention & control MeSH
- Ventricular Premature Complexes etiology metabolism physiopathology prevention & control MeSH
- Disease Models, Animal MeSH
- Cerebral Ventricles metabolism physiopathology drug effects MeSH
- Rats, Wistar MeSH
- Receptor, Endothelin A metabolism drug effects MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
Endothelin alters central sympathetic responses, but the resultant effects on arrhythmogenesis are unknown. We examined ventricular tachyarrhythmias after endothelin receptor-A blockade in the brain of Wistar rats with acute myocardial infarction. For this aim, BQ-123 (n=6) or phosphate-buffered saline (n=6) were injected intracerebroventricularly. After 10 min, the left coronary artery was ligated, followed by implantation of telemetry transmitters. Electrocardiography and voluntary activity (as a surrogate of acute left ventricular failure) were continuously monitored for 24 h. Infarct-size was similar in the two groups. There were fewer episodes of ventricular tachyarrhythmias of shorter average duration in treated rats, leading to markedly shorter total duration (12.3+/-8.9 s), when compared to controls (546.2+/-130.3 s). Voluntary activity increased in treated rats during the last hours of recording, but bradyarrhythmic episodes were comparable between the two groups. Endothelin receptor-A blockade in the brain of rats decreases the incidence of ventricular tachyarrhythmias post-ligation, without affecting bradyarrhythmic episodes. These findings call for further research on the pathophysiologic role of endothelin during acute myocardial infarction.
Cardiovascular Research Institute University of Ioannina Ioannina Greece
Department of Cardiology Medical School University of Ioannina Ioannina Greece
References provided by Crossref.org
Literatura
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