-
Je něco špatně v tomto záznamu ?
Telomerase activity is upregulated in the fat bodies of pre-diapause bumblebee queens (Bombus terrestris)
J. Koubová, T. Jehlík, D. Kodrík, M. Sábová, P. Šima, H. Sehadová, R. Závodská, RČ. Frydrychová,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
31536769
DOI
10.1016/j.ibmb.2019.103241
Knihovny.cz E-zdroje
- MeSH
- DNA biosyntéza MeSH
- telomerasa metabolismus MeSH
- tukové těleso enzymologie MeSH
- včely enzymologie MeSH
- zkracování telomer MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The attrition of telomeres, the ends of eukaryote chromosomes, and activity of telomerase, the enzyme that restores telomere length, play a role in the ageing process and act as indicators of biological age. A notable feature of advanced eusocial insects is the longevity of reproductive individuals (queens and kings) compared to those from non-reproductive castes (workers and soldiers) within a given species, with a proposed link towards upregulation of telomerase activity in the somatic tissues of reproductive individuals. Given this, eusocial insects provide excellent model systems for research into ageing. We tested telomerase activity and measured telomere length in Bombus terrestris, which is a primitively eusocial insect species with several distinct features compared to advanced social insects. In somatic tissues, telomerase activity was upregulated only in the fat bodies of pre-diapause queens, and this upregulation was linked to heightened DNA synthesis. Telomere length was shorter in old queens compared to that in younger queens or workers. We speculate that (1) the upregulation of telomerase activity, together with DNA synthesis, is the essential step for intensifying metabolic activity in the fat body to build up a sufficient energy reserve prior to diapause, and that (2) the lifespan differences between B. terrestris workers and queens are related to the long diapause period of the queen. A possible relationship between telomere length regulation and TOR, FOXO, and InR as cell signaling components, was tested.
Faculty of Science University of South Bohemia Branišovská 31 370 05 České Budějovice Czech Republic
Koppert s r o Komárňanská cesta 13 940 01 Nové Zámky Slovakia
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20005890
- 003
- CZ-PrNML
- 005
- 20200518132151.0
- 007
- ta
- 008
- 200511s2019 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ibmb.2019.103241 $2 doi
- 035 __
- $a (PubMed)31536769
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Koubová, Justina $u Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Branišovská 31, 370 05, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 31, 370 05, České Budějovice, Czech Republic.
- 245 10
- $a Telomerase activity is upregulated in the fat bodies of pre-diapause bumblebee queens (Bombus terrestris) / $c J. Koubová, T. Jehlík, D. Kodrík, M. Sábová, P. Šima, H. Sehadová, R. Závodská, RČ. Frydrychová,
- 520 9_
- $a The attrition of telomeres, the ends of eukaryote chromosomes, and activity of telomerase, the enzyme that restores telomere length, play a role in the ageing process and act as indicators of biological age. A notable feature of advanced eusocial insects is the longevity of reproductive individuals (queens and kings) compared to those from non-reproductive castes (workers and soldiers) within a given species, with a proposed link towards upregulation of telomerase activity in the somatic tissues of reproductive individuals. Given this, eusocial insects provide excellent model systems for research into ageing. We tested telomerase activity and measured telomere length in Bombus terrestris, which is a primitively eusocial insect species with several distinct features compared to advanced social insects. In somatic tissues, telomerase activity was upregulated only in the fat bodies of pre-diapause queens, and this upregulation was linked to heightened DNA synthesis. Telomere length was shorter in old queens compared to that in younger queens or workers. We speculate that (1) the upregulation of telomerase activity, together with DNA synthesis, is the essential step for intensifying metabolic activity in the fat body to build up a sufficient energy reserve prior to diapause, and that (2) the lifespan differences between B. terrestris workers and queens are related to the long diapause period of the queen. A possible relationship between telomere length regulation and TOR, FOXO, and InR as cell signaling components, was tested.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a včely $x enzymologie $7 D001516
- 650 _2
- $a DNA $x biosyntéza $7 D004247
- 650 _2
- $a tukové těleso $x enzymologie $7 D005216
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a telomerasa $x metabolismus $7 D019098
- 650 _2
- $a zkracování telomer $7 D059506
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Jehlík, Tomáš $u Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Branišovská 31, 370 05, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 31, 370 05, České Budějovice, Czech Republic.
- 700 1_
- $a Kodrík, Dalibor $u Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Branišovská 31, 370 05, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 31, 370 05, České Budějovice, Czech Republic.
- 700 1_
- $a Sábová, Michala $u Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Branišovská 31, 370 05, České Budějovice, Czech Republic.
- 700 1_
- $a Šima, Peter $u Koppert s.r.o., Komárňanská cesta 13, 940 01, Nové Zámky, Slovakia.
- 700 1_
- $a Sehadová, Hana $u Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Branišovská 31, 370 05, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 31, 370 05, České Budějovice, Czech Republic.
- 700 1_
- $a Závodská, Radka $u Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Branišovská 31, 370 05, České Budějovice, Czech Republic; Faculty of Pedagogy, University of South Bohemia, Branišovská 31, 370 05, České Budějovice, Czech Republic.
- 700 1_
- $a Frydrychová, Radmila Čapková $u Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Branišovská 31, 370 05, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 31, 370 05, České Budějovice, Czech Republic. Electronic address: Radmila.Frydrychova@hotmail.com.
- 773 0_
- $w MED00004948 $t Insect biochemistry and molecular biology $x 1879-0240 $g Roč. 115, č. - (2019), s. 103241
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31536769 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200511 $b ABA008
- 991 __
- $a 20200518132151 $b ABA008
- 999 __
- $a ok $b bmc $g 1524748 $s 1095946
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 115 $c - $d 103241 $e 20190916 $i 1879-0240 $m Insect biochemistry and molecular biology $n Insect Biochem Mol Biol $x MED00004948
- LZP __
- $a Pubmed-20200511