INTRODUCTION: Cannabinoids are organic compounds, natural or synthetic, that bind to the cannabinoid receptors and have similar pharmacological properties as produced by the cannabis plant, Cannabis sativa. Gas chromatography (GC), e.g. gas chromatography mass spectrometry (GC-MS), is a popular analytical tool that has been used extensively to analyse cannabinoids in various matrices. OBJECTIVE: To review published literature on the use of various GC-based analytical methods for the analysis of naturally occurring cannabinoids published during the past decade. METHODOLOGY: A comprehensive literature search was performed utilising several databases, like Web of Knowledge, PubMed and Google Scholar, and other relevant published materials including published books. The keywords used, in various combinations, with cannabinoids being present in all combinations, in the search were cannabinoids, Cannabis sativa, marijuana, analysis, GC, quantitative, qualitative and quality control. RESULTS: During the past decade, several GC-based methods for the analysis of cannabinoids have been reported. While simple one-dimensional (1D) GC-MS and GC-FID (flame ionisation detector) methods were found to be quite common in cannabinoids analysis, two-dimensional (2D) GC-MS as well as GC-MS/MS also were popular because of their ability to provide more useful data for identification and quantification of cannabinoids in various matrices. Some degree of automation in sample preparation, and applications of mathematical and computational models for optimisation of different protocols were observed, and pre-analyses included various derivatisation techniques, and environmentally friendly extraction protocols. CONCLUSIONS: GC-based analysis of naturally occurring cannabinoids, especially using GC-MS, has dominated the cannabinoids analysis in the last decade; new derivatisation methods, new ionisation methods, and mathematical models for method optimisation have been introduced.

Centre for Natural Products Discovery School of Pharmacy and Biomolecular Sciences Liverpool John Moores University Liverpool UK

Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical Garden Chinese Academy of Sciences Wuhan China Sino Africa Joint Research Center Chinese Academy of Sciences Wuhan China

Laboratory of Growth Regulators Institute of Experimental Botany ASCR and Palacký University Olomouc Czech Republic

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