• Je něco špatně v tomto záznamu ?

A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction

EB. Dolan, B. Hofmann, MH. de Vaal, G. Bellavia, S. Straino, L. Kovarova, M. Pravda, V. Velebny, D. Daro, N. Braun, DS. Monahan, RE. Levey, H. O'Neill, S. Hinderer, R. Greensmith, MG. Monaghan, K. Schenke-Layland, P. Dockery, BP. Murphy, HM....

. 2019 ; 103 (-) : 109751. [pub] 20190515

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20006111

The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the weakened myocardium and regenerative approaches (specifically stem cell technologies) have evolved which aim to prevent CHF. However, their final performance remains limited motivating the need for an advanced strategy with enhanced efficacy and reduced deleterious effects. An epicardial carrier device enabling a targeted application of a biomaterial-based therapy to the infarcted ventricle wall could potentially overcome the therapy and application related issues. Such a device could play a synergistic role in heart regeneration, including the provision of mechanical support to the remodeling heart wall, as well as providing a suitable environment for in situ stem cell delivery potentially promoting heart regeneration. In this study, we have developed a novel, single-stage concept to support the weakened myocardial region post-MI by applying an elastic, biodegradable patch (SPREADS) via a minimal-invasive, closed chest intervention to the epicardial heart surface. We show a significant increase in %LVEF 14 days post-treatment when GS (clinical gold standard treatment) was compared to GS + SPREADS + Gel with and without cells (p ≤ 0.001). Furthermore, we did not find a significant difference in infarct quality or blood vessel density between any of the groups which suggests that neither infarct quality nor vascularization is the mechanism of action of SPREADS. The SPREADS device could potentially be used to deliver a range of new or previously developed biomaterial hydrogels, a remarkable potential to overcome the translational hurdles associated with hydrogel delivery to the heart.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20006111
003      
CZ-PrNML
005      
20200518132336.0
007      
ta
008      
200511s2019 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.msec.2019.109751 $2 doi
035    __
$a (PubMed)31349422
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Dolan, Eimear B $u School of Pharmacy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland; Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland; Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Ireland; Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
245    12
$a A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction / $c EB. Dolan, B. Hofmann, MH. de Vaal, G. Bellavia, S. Straino, L. Kovarova, M. Pravda, V. Velebny, D. Daro, N. Braun, DS. Monahan, RE. Levey, H. O'Neill, S. Hinderer, R. Greensmith, MG. Monaghan, K. Schenke-Layland, P. Dockery, BP. Murphy, HM. Kelly, S. Wildhirt, GP. Duffy,
520    9_
$a The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the weakened myocardium and regenerative approaches (specifically stem cell technologies) have evolved which aim to prevent CHF. However, their final performance remains limited motivating the need for an advanced strategy with enhanced efficacy and reduced deleterious effects. An epicardial carrier device enabling a targeted application of a biomaterial-based therapy to the infarcted ventricle wall could potentially overcome the therapy and application related issues. Such a device could play a synergistic role in heart regeneration, including the provision of mechanical support to the remodeling heart wall, as well as providing a suitable environment for in situ stem cell delivery potentially promoting heart regeneration. In this study, we have developed a novel, single-stage concept to support the weakened myocardial region post-MI by applying an elastic, biodegradable patch (SPREADS) via a minimal-invasive, closed chest intervention to the epicardial heart surface. We show a significant increase in %LVEF 14 days post-treatment when GS (clinical gold standard treatment) was compared to GS + SPREADS + Gel with and without cells (p ≤ 0.001). Furthermore, we did not find a significant difference in infarct quality or blood vessel density between any of the groups which suggests that neither infarct quality nor vascularization is the mechanism of action of SPREADS. The SPREADS device could potentially be used to deliver a range of new or previously developed biomaterial hydrogels, a remarkable potential to overcome the translational hurdles associated with hydrogel delivery to the heart.
650    12
$a vstřebatelné implantáty $7 D020341
650    _2
$a tuková tkáň $x cytologie $7 D000273
650    _2
$a zvířata $7 D000818
650    _2
$a biokompatibilní materiály $7 D001672
650    _2
$a pohyb buněk $x účinky léků $7 D002465
650    _2
$a buněčná a tkáňová terapie $x přístrojové vybavení $x metody $7 D064987
650    _2
$a design vybavení $7 D004867
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a kyselina hyaluronová $7 D006820
650    _2
$a hydrogely $x aplikace a dávkování $x chemie $x farmakologie $7 D020100
650    _2
$a transplantace mezenchymálních kmenových buněk $7 D045164
650    12
$a mezenchymální kmenové buňky $x účinky léků $7 D059630
650    _2
$a infarkt myokardu $x patofyziologie $x terapie $7 D009203
650    _2
$a perikard $7 D010496
650    _2
$a prasata $7 D013552
650    _2
$a viskozita $7 D014783
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hofmann, Björn $u AdjuCor GmbH, Lichtenbergstr. 8, 85748 Garching, Germany; Eberhard Karls University Tübingen, Department of Women's Health, Research Institute for Women's Health, Silcherstr. 7/1, 72076 Tübingen, Germany.
700    1_
$a de Vaal, M Hamman $u AdjuCor GmbH, Lichtenbergstr. 8, 85748 Garching, Germany.
700    1_
$a Bellavia, Gabriella $u Explora Biotech Srl, G. Peroni 386, 00131 Rome, Italy.
700    1_
$a Straino, Stefania $u Explora Biotech Srl, G. Peroni 386, 00131 Rome, Italy.
700    1_
$a Kovarova, Lenka $u R&D Department, Contipro, Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic; Brno University of Technology, Faculty of Chemistry, Institute of Physical Chemistry, Purkynova 464/118, 612 00 Brno, Czech Republic.
700    1_
$a Pravda, Martin $u R&D Department, Contipro, Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic.
700    1_
$a Velebny, Vladimir $u R&D Department, Contipro, Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic.
700    1_
$a Daro, Dorothee $u Celyad SA, Mont-Saint-Guibert, Belgium.
700    1_
$a Braun, Nathalie $u Celyad SA, Mont-Saint-Guibert, Belgium.
700    1_
$a Monahan, David S $u Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Ireland.
700    1_
$a Levey, Ruth E $u Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Ireland.
700    1_
$a O'Neill, Hugh $u Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
700    1_
$a Hinderer, Svenja $u Eberhard Karls University Tübingen, Department of Women's Health, Research Institute for Women's Health, Silcherstr. 7/1, 72076 Tübingen, Germany; Natural and Medical Sciences Institute (NMI) at the University of Tübingen, Markwiesenstr. 55, 72770 Reutlingen, Germany.
700    1_
$a Greensmith, Robert $u Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
700    1_
$a Monaghan, Michael G $u Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
700    1_
$a Schenke-Layland, Katja $u Eberhard Karls University Tübingen, Department of Women's Health, Research Institute for Women's Health, Silcherstr. 7/1, 72076 Tübingen, Germany; Natural and Medical Sciences Institute (NMI) at the University of Tübingen, Markwiesenstr. 55, 72770 Reutlingen, Germany.
700    1_
$a Dockery, Peter $u Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Ireland.
700    1_
$a Murphy, Bruce P $u Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Royal College of Surgeons Ireland, & National University of Ireland Galway, Ireland.
700    1_
$a Kelly, Helena M $u School of Pharmacy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland; Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
700    1_
$a Wildhirt, Stephen $u AdjuCor GmbH, Lichtenbergstr. 8, 85748 Garching, Germany.
700    1_
$a Duffy, Garry P $u Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland; Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Ireland; Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Royal College of Surgeons Ireland, & National University of Ireland Galway, Ireland. Electronic address: garry.duffy@nuigalway.ie.
773    0_
$w MED00184559 $t Materials science & engineering. C, Materials for biological applications $x 1873-0191 $g Roč. 103, č. - (2019), s. 109751
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31349422 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20200518132336 $b ABA008
999    __
$a ok $b bmc $g 1524969 $s 1096167
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 103 $c - $d 109751 $e 20190515 $i 1873-0191 $m Materials science & engineering. C, Materials for biological applications $n Mater Sci Eng C Mater Biol Appl $x MED00184559
LZP    __
$a Pubmed-20200511

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace