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Clustered Core- and Pan-Genome Content on Rhodobacteraceae Chromosomes
K. Kopejtka, Y. Lin, M. Jakubovičová, M. Koblížek, J. Tomasch,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Free Medical Journals od 2009
PubMed Central od 2009
Europe PubMed Central od 2009
Open Access Digital Library od 2009-01-01
Open Access Digital Library od 2009-01-01
Open Access Digital Library od 2009-01-01
Oxford Journals Open Access Collection od 2009
ROAD: Directory of Open Access Scholarly Resources od 2009
Odkazy
PubMed
31273387
DOI
10.1093/gbe/evz138
Knihovny.cz E-zdroje
- MeSH
- bakteriální chromozomy genetika MeSH
- bakteriální proteiny genetika MeSH
- fylogeneze * MeSH
- genom bakteriální * MeSH
- regulace genové exprese u bakterií MeSH
- replikace DNA MeSH
- Rhodobacteraceae genetika MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
In Bacteria, chromosome replication starts at a single origin of replication and proceeds on both replichores. Due to its asymmetric nature, replication influences chromosome structure and gene organization, mutation rate, and expression. To date, little is known about the distribution of highly conserved genes over the bacterial chromosome. Here, we used a set of 101 fully sequenced Rhodobacteraceae representatives to analyze the relationship between conservation of genes within this family and their distance from the origin of replication. Twenty-two of the analyzed species had core genes clustered significantly closer to the origin of replication with representatives of the genus Celeribacter being the most apparent example. Interestingly, there were also eight species with the opposite organization. In particular, Rhodobaca barguzinensis and Loktanella vestfoldensis showed a significant increase of core genes with distance from the origin of replication. The uneven distribution of low-conserved regions is in particular pronounced for genomes in which the halves of one replichore differ in their conserved gene content. Phage integration and horizontal gene transfer partially explain the scattered nature of Rhodobacteraceae genomes. Our findings lay the foundation for a better understanding of bacterial genome evolution and the role of replication therein.
Department of Molecular Bacteriology Helmholtz Centre for Infection Research Braunschweig Germany
Faculty of Information Technology Czech Technical University Prague Czech Republic
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- $a Kopejtka, Karel $u Laboratory of Anoxygenic Phototrophs, Center Algatech, Institute of Microbiology CAS, Třeboň, Czech Republic. Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
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