-
Je něco špatně v tomto záznamu ?
Clustered Core- and Pan-Genome Content on Rhodobacteraceae Chromosomes
K. Kopejtka, Y. Lin, M. Jakubovičová, M. Koblížek, J. Tomasch,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2009
Free Medical Journals
od 2009
PubMed Central
od 2009
Europe PubMed Central
od 2009
Open Access Digital Library
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Oxford Journals Open Access Collection
od 2009
ROAD: Directory of Open Access Scholarly Resources
od 2009
PubMed
31273387
DOI
10.1093/gbe/evz138
Knihovny.cz E-zdroje
- MeSH
- bakteriální chromozomy genetika MeSH
- bakteriální proteiny genetika MeSH
- fylogeneze * MeSH
- genom bakteriální * MeSH
- regulace genové exprese u bakterií MeSH
- replikace DNA MeSH
- Rhodobacteraceae genetika MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
In Bacteria, chromosome replication starts at a single origin of replication and proceeds on both replichores. Due to its asymmetric nature, replication influences chromosome structure and gene organization, mutation rate, and expression. To date, little is known about the distribution of highly conserved genes over the bacterial chromosome. Here, we used a set of 101 fully sequenced Rhodobacteraceae representatives to analyze the relationship between conservation of genes within this family and their distance from the origin of replication. Twenty-two of the analyzed species had core genes clustered significantly closer to the origin of replication with representatives of the genus Celeribacter being the most apparent example. Interestingly, there were also eight species with the opposite organization. In particular, Rhodobaca barguzinensis and Loktanella vestfoldensis showed a significant increase of core genes with distance from the origin of replication. The uneven distribution of low-conserved regions is in particular pronounced for genomes in which the halves of one replichore differ in their conserved gene content. Phage integration and horizontal gene transfer partially explain the scattered nature of Rhodobacteraceae genomes. Our findings lay the foundation for a better understanding of bacterial genome evolution and the role of replication therein.
Department of Molecular Bacteriology Helmholtz Centre for Infection Research Braunschweig Germany
Faculty of Information Technology Czech Technical University Prague Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20006188
- 003
- CZ-PrNML
- 005
- 20200526132009.0
- 007
- ta
- 008
- 200511s2019 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1093/gbe/evz138 $2 doi
- 035 __
- $a (PubMed)31273387
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Kopejtka, Karel $u Laboratory of Anoxygenic Phototrophs, Center Algatech, Institute of Microbiology CAS, Třeboň, Czech Republic. Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
- 245 10
- $a Clustered Core- and Pan-Genome Content on Rhodobacteraceae Chromosomes / $c K. Kopejtka, Y. Lin, M. Jakubovičová, M. Koblížek, J. Tomasch,
- 520 9_
- $a In Bacteria, chromosome replication starts at a single origin of replication and proceeds on both replichores. Due to its asymmetric nature, replication influences chromosome structure and gene organization, mutation rate, and expression. To date, little is known about the distribution of highly conserved genes over the bacterial chromosome. Here, we used a set of 101 fully sequenced Rhodobacteraceae representatives to analyze the relationship between conservation of genes within this family and their distance from the origin of replication. Twenty-two of the analyzed species had core genes clustered significantly closer to the origin of replication with representatives of the genus Celeribacter being the most apparent example. Interestingly, there were also eight species with the opposite organization. In particular, Rhodobaca barguzinensis and Loktanella vestfoldensis showed a significant increase of core genes with distance from the origin of replication. The uneven distribution of low-conserved regions is in particular pronounced for genomes in which the halves of one replichore differ in their conserved gene content. Phage integration and horizontal gene transfer partially explain the scattered nature of Rhodobacteraceae genomes. Our findings lay the foundation for a better understanding of bacterial genome evolution and the role of replication therein.
- 650 _2
- $a bakteriální proteiny $x genetika $7 D001426
- 650 _2
- $a bakteriální chromozomy $x genetika $7 D002876
- 650 _2
- $a replikace DNA $7 D004261
- 650 _2
- $a regulace genové exprese u bakterií $7 D015964
- 650 12
- $a genom bakteriální $7 D016680
- 650 12
- $a fylogeneze $7 D010802
- 650 _2
- $a Rhodobacteraceae $x genetika $7 D041902
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Lin, Yan $u Department of Physics, School of Science, Tianjin University, China. SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China.
- 700 1_
- $a Jakubovičová, Markéta $u Faculty of Information Technology, Czech Technical University in Prague, Czech Republic.
- 700 1_
- $a Koblížek, Michal $u Laboratory of Anoxygenic Phototrophs, Center Algatech, Institute of Microbiology CAS, Třeboň, Czech Republic. Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
- 700 1_
- $a Tomasch, Jürgen $u Department of Molecular Bacteriology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
- 773 0_
- $w MED00170504 $t Genome biology and evolution $x 1759-6653 $g Roč. 11, č. 8 (2019), s. 2208-2217
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31273387 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200511 $b ABA008
- 991 __
- $a 20200526132005 $b ABA008
- 999 __
- $a ok $b bmc $g 1525046 $s 1096244
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 11 $c 8 $d 2208-2217 $e 20190801 $i 1759-6653 $m Genome biology and evolution $n Genome Biol Evol $x MED00170504
- LZP __
- $a Pubmed-20200511