Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis

A. Braunova, L. Krbkova, P. Rainetova, M. Musilek, I. Capovova, L. Klapacova, V. Musil, L. Homola, T. Kravalova, J. Bednarova, M. Kyr

. 2019 ; 163 (4) : 355-361. [pub] 20190110

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20010315

AIMS: Enteroviruses (EVs) are the most common agents of aseptic meningitis. Some serotypes can cause serious neuroinfection leading to death. The aim of this study was to determine the representation of EVs in the etiology of aseptic meningitis in children and to analyze the demographic, clinical, laboratory, and epidemiological characteristics of patients with EV meningitis. PATIENTS AND METHODS: This was a prospective study including 147 patients in three groups: EV meningitis, tick-borne encephalitis, and aseptic meningitis with unidentified agent. RESULTS: Boys with EV meningitis predominated over girls. The average patient age was 11 years. Compared to the control group, these patients suffered more from stiff back (P=0.010), vomiting and nausea (P=0.009). They had shorter symptom duration (P<0.001), higher C-reactive protein in blood (P<0.001), higher predominance of polynuclears (P=0.026), and greater lactate (P=0.003) in cerebrospinal fluid (CSF). The serotype seen most frequently (68%) was ECHO virus (ECV) 30. CONCLUSIONS: Enteroviruses play the most important role in the differential diagnosis of aseptic meningitis. Short symptom duration, slightly higher inflammatory parameters in blood, predominance of polynuclears, and elevated CSF lactate have predictive value in diagnosing this disease. ECV 30 (frequently the agent of epidemics in the Czech Republic) was the aseptic meningitis agent most often seen.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc20010315
003      
CZ-PrNML
005      
20200720150808.0
007      
ta
008      
200707s2019 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2018.082 $2 doi
035    __
$a (PubMed)30631207
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Braunová, Adriana $7 xx0237576 $u Department of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
245    10
$a Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis / $c A. Braunova, L. Krbkova, P. Rainetova, M. Musilek, I. Capovova, L. Klapacova, V. Musil, L. Homola, T. Kravalova, J. Bednarova, M. Kyr
504    __
$a Literatura
520    9_
$a AIMS: Enteroviruses (EVs) are the most common agents of aseptic meningitis. Some serotypes can cause serious neuroinfection leading to death. The aim of this study was to determine the representation of EVs in the etiology of aseptic meningitis in children and to analyze the demographic, clinical, laboratory, and epidemiological characteristics of patients with EV meningitis. PATIENTS AND METHODS: This was a prospective study including 147 patients in three groups: EV meningitis, tick-borne encephalitis, and aseptic meningitis with unidentified agent. RESULTS: Boys with EV meningitis predominated over girls. The average patient age was 11 years. Compared to the control group, these patients suffered more from stiff back (P=0.010), vomiting and nausea (P=0.009). They had shorter symptom duration (P<0.001), higher C-reactive protein in blood (P<0.001), higher predominance of polynuclears (P=0.026), and greater lactate (P=0.003) in cerebrospinal fluid (CSF). The serotype seen most frequently (68%) was ECHO virus (ECV) 30. CONCLUSIONS: Enteroviruses play the most important role in the differential diagnosis of aseptic meningitis. Short symptom duration, slightly higher inflammatory parameters in blood, predominance of polynuclears, and elevated CSF lactate have predictive value in diagnosing this disease. ECV 30 (frequently the agent of epidemics in the Czech Republic) was the aseptic meningitis agent most often seen.
650    _2
$a mladiství $7 D000293
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    _2
$a Enterovirus $x genetika $7 D004770
650    _2
$a enterovirové infekce $x epidemiologie $x genetika $x patofyziologie $7 D004769
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a meningitida aseptická $x genetika $x patofyziologie $7 D008582
650    _2
$a meningitida virová $x epidemiologie $x genetika $x patofyziologie $7 D008587
650    _2
$a prospektivní studie $7 D011446
650    _2
$a polymerázová řetězová reakce s reverzní transkripcí $7 D020133
650    _2
$a sekvenční analýza $7 D017421
651    _2
$a Česká republika $x epidemiologie $7 D018153
655    _2
$a časopisecké články $7 D016428
700    1_
$a Krbková, Lenka $7 mzk2005313088 $u Department of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
700    1_
$a Rainetová, Petra $7 xx0103935 $u National Reference Laboratory for Enteroviruses, Prague, Czech Republic; National Reference Laboratory for Meningococcal Infections, Prague, Czech Republic
700    1_
$a Musílek, Martin $7 xx0060586 $u National Reference Laboratory for Meningococcal Infections, Prague, Czech Republic
700    1_
$a Čapovová, Iva $7 xx0121926 $u Department of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
700    1_
$a Klapačová, Lenka $7 xx0127848 $u Department of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
700    1_
$a Musil, Václav $7 xx0237573 $u Department of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
700    1_
$a Homola, Lukáš $7 xx0235587 $u Department of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
700    1_
$a Kravalová, Tamara $7 xx0239429 $u Department of Children's Infectious Disease, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
700    1_
$a Bednářová, Jana $7 xx0195193 $u Department of Clinical Microbiology, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
700    1_
$a Kýr, Michal, $d 1979- $7 mub2014808498 $u Department of Children's Oncology, Faculty of Medicine and University Hospital, Masaryk University, Brno, Czech Republic
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia $x 1213-8118 $g Roč. 163, č. 4 (2019), s. 355-361
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30631207 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y p $z 0
990    __
$a 20200707 $b ABA008
991    __
$a 20200717085647 $b ABA008
999    __
$a ok $b bmc $g 1545956 $s 1100407
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 163 $c 4 $d 355-361 $e 20190110 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20200707

Najít záznam

Citační ukazatele

Možnosti archivace