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Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients
C. Berking, J. Hegyi, P. Arenberger, T. Ruzicka, GB. Jemec,
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, multicentrická studie
NLK
Karger Journals
od 1992 do 2009
ProQuest Central
od 1998-01-01 do 2015-11-30
Medline Complete (EBSCOhost)
od 2005-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 1998-01-01 do 2015-11-30
Health & Medicine (ProQuest)
od 1998-01-01 do 2015-11-30
PubMed
19060464
DOI
10.1159/000182259
Knihovny.cz E-zdroje
- MeSH
- aplikace kožní MeSH
- bérec patologie MeSH
- dospělí MeSH
- fotochemoterapie metody MeSH
- fotosenzibilizující látky aplikace a dávkování MeSH
- kyselina aminolevulová aplikace a dávkování analogy a deriváty MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- necrobiosis lipoidica farmakoterapie patologie MeSH
- retrospektivní studie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Česká republika MeSH
- Dánsko MeSH
- Německo MeSH
BACKGROUND: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT). OBJECTIVE: To evaluate the overall potential of PDT in the treatment of NL on the lower legs. METHODS: Retrospective study of 18 patients (aged 16-62 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light. RESULTS: Complete response was seen in 1/18 patients after 9 PDT cycles, and partial response in 6/18 patients (2-14 PDT cycles) giving an overall response rate of 39% (7/18). CONCLUSION: Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT.
Citace poskytuje Crossref.org
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