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FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells

M. Stefanik, JJ. Valdes, FC. Ezebuo, J. Haviernik, IC. Uzochukwu, M. Fojtikova, J. Salat, L. Eyer, D. Ruzek,

. 2020 ; 8 (4) : . [pub] 20200420

Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc20019309

Grant support
16-34238A Ministerstvo Zdravotnictví Ceské Republiky
CZ.02.1.01/0.0/0.0/15_003/0000495 Ministerstvo Školství, Mládeže a Tělovýchovy
NV16-34238A MZ0 CEP Register

Vector-borne flaviviruses (VBFs) affect human health worldwide, but no approved drugs are available specifically to treat VBF-associated infections. Here, we performed in silico screening of a library of U.S. Food and Drug Administration-approved antiviral drugs for their interaction with Zika virus proteins. Twelve hit drugs were identified by the docking experiments and tested in cell-based antiviral assay systems. Efavirenz, tipranavir, and dasabuvir at micromolar concentrations were identified to inhibit all VBFs tested; i.e., two representatives of mosquito-borne flaviviruses (Zika and West Nile viruses) and one representative of flaviviruses transmitted by ticks (tick-borne encephalitis virus). The results warrant further research into these drugs, either individually or in combination, as possible pan-flavivirus inhibitors.

References provided by Crossref.org

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