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Inventory and Evolution of Mitochondrion-localized Family A DNA Polymerases in Euglenozoa

R. Harada, Y. Hirakawa, A. Yabuki, Y. Kashiyama, M. Maruyama, R. Onuma, P. Soukal, S. Miyagishima, V. Hampl, G. Tanifuji, Y. Inagaki,

. 2020 ; 9 (4) : . [pub] 20200401

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20019397

Grantová podpora
18KK0203 and 19H03280, YI; 17H03723 and 26840123, GT; 17K19434, AY Japan Society for the Promotion of Science
16-25280S, VH the Czech Science foundation
CZ.02.1.01/0.0/0.0/16_019/0000759 Centre for research of pathogenicity and virulence of parasites

The order Trypanosomatida has been well studied due to its pathogenicity and the unique biology of the mitochondrion. In Trypanosoma brucei, four DNA polymerases, namely PolIA, PolIB, PolIC, and PolID, related to bacterial DNA polymerase I (PolI), were shown to be localized in mitochondria experimentally. These mitochondrion-localized DNA polymerases are phylogenetically distinct from other family A DNA polymerases, such as bacterial PolI, DNA polymerase gamma (Polγ) in human and yeasts, "plant and protist organellar DNA polymerase (POP)" in diverse eukaryotes. However, the diversity of mitochondrion-localized DNA polymerases in Euglenozoa other than Trypanosomatida is poorly understood. In this study, we discovered putative mitochondrion-localized DNA polymerases in broad members of three major classes of Euglenozoa-Kinetoplastea, Diplonemea, and Euglenida-to explore the origin and evolution of trypanosomatid PolIA-D. We unveiled distinct inventories of mitochondrion-localized DNA polymerases in the three classes: (1) PolIA is ubiquitous across the three euglenozoan classes, (2) PolIB, C, and D are restricted in kinetoplastids, (3) new types of mitochondrion-localized DNA polymerases were identified in a prokinetoplastid and diplonemids, and (4) evolutionarily distinct types of POP were found in euglenids. We finally propose scenarios to explain the inventories of mitochondrion-localized DNA polymerases in Kinetoplastea, Diplonemea, and Euglenida.

Citace poskytuje Crossref.org

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$a Harada, Ryo $u Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.
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$a The order Trypanosomatida has been well studied due to its pathogenicity and the unique biology of the mitochondrion. In Trypanosoma brucei, four DNA polymerases, namely PolIA, PolIB, PolIC, and PolID, related to bacterial DNA polymerase I (PolI), were shown to be localized in mitochondria experimentally. These mitochondrion-localized DNA polymerases are phylogenetically distinct from other family A DNA polymerases, such as bacterial PolI, DNA polymerase gamma (Polγ) in human and yeasts, "plant and protist organellar DNA polymerase (POP)" in diverse eukaryotes. However, the diversity of mitochondrion-localized DNA polymerases in Euglenozoa other than Trypanosomatida is poorly understood. In this study, we discovered putative mitochondrion-localized DNA polymerases in broad members of three major classes of Euglenozoa-Kinetoplastea, Diplonemea, and Euglenida-to explore the origin and evolution of trypanosomatid PolIA-D. We unveiled distinct inventories of mitochondrion-localized DNA polymerases in the three classes: (1) PolIA is ubiquitous across the three euglenozoan classes, (2) PolIB, C, and D are restricted in kinetoplastids, (3) new types of mitochondrion-localized DNA polymerases were identified in a prokinetoplastid and diplonemids, and (4) evolutionarily distinct types of POP were found in euglenids. We finally propose scenarios to explain the inventories of mitochondrion-localized DNA polymerases in Kinetoplastea, Diplonemea, and Euglenida.
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$a Hirakawa, Yoshihisa $u Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.
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$a Yabuki, Akinori $u Japan Agency for Marine-Earth Science and Technology, Yokosuka 236-0001, Japan.
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$a Kashiyama, Yuichiro $u Department of Applied Chemistry and Food Science, Fukui University of Technology, Fukui 910-8505, Japan. Graduate School of Engineering, Fukui University of Technology, Fukui 910-8505, Japan.
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$a Maruyama, Moe $u Graduate School of Engineering, Fukui University of Technology, Fukui 910-8505, Japan.
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$a Onuma, Ryo $u Department of Gene Function and Phenomics, National Institute of Genetics, Mishima 411-8540, Japan.
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$a Soukal, Petr $u Department of Parasitology, Charles University, Faculty of Science, BIOCEV, 252 42 Vestec, Czech Republic.
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$a Miyagishima, Shinya $u Department of Gene Function and Phenomics, National Institute of Genetics, Mishima 411-8540, Japan.
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$a Hampl, Vladimír $u Department of Parasitology, Charles University, Faculty of Science, BIOCEV, 252 42 Vestec, Czech Republic.
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$a Inagaki, Yuji $u Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan. Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan. Center for Computational Sciences, University of Tsukuba, Tsukuba 305-8577, Japan.
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