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Determinants of Fatal Outcome in Patients Admitted to Intensive Care Units With Influenza, European Union 2009-2017

C. Adlhoch, J. Gomes Dias, I. Bonmarin, B. Hubert, A. Larrauri, JA. Oliva Domínguez, C. Delgado-Sanz, M. Brytting, A. Carnahan, O. Popovici, E. Lupulescu, J. O'Donnell, L. Domegan, AB. Van Gageldonk-Lafeber, A. Meijer, J. Kynčl, P. Slezák, R....

. 2019 ; 6 (11) : ofz462. [pub] 20191029

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20019476

Background: Morbidity, severity, and mortality associated with annual influenza epidemics are of public health concern. We analyzed surveillance data on hospitalized laboratory-confirmed influenza cases admitted to intensive care units to identify common determinants for fatal outcome and inform and target public health prevention strategies, including risk communication. Methods: We performed a descriptive analysis and used Poisson regression models with robust variance to estimate the association of age, sex, virus (sub)type, and underlying medical condition with fatal outcome using European Union data from 2009 to 2017. Results: Of 13 368 cases included in the basic dataset, 2806 (21%) were fatal. Age ≥40 years and infection with influenza A virus were associated with fatal outcome. Of 5886 cases with known underlying medical conditions and virus A subtype included in a more detailed analysis, 1349 (23%) were fatal. Influenza virus A(H1N1)pdm09 or A(H3N2) infection, age ≥60 years, cancer, human immunodeficiency virus infection and/or other immune deficiency, and heart, kidney, and liver disease were associated with fatal outcome; the risk of death was lower for patients with chronic lung disease and for pregnant women. Conclusions: This study re-emphasises the importance of preventing influenza in the elderly and tailoring strategies to risk groups with underlying medical conditions.

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$a Adlhoch, Cornelia $u Surveillance and Response Support, European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.
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$a Background: Morbidity, severity, and mortality associated with annual influenza epidemics are of public health concern. We analyzed surveillance data on hospitalized laboratory-confirmed influenza cases admitted to intensive care units to identify common determinants for fatal outcome and inform and target public health prevention strategies, including risk communication. Methods: We performed a descriptive analysis and used Poisson regression models with robust variance to estimate the association of age, sex, virus (sub)type, and underlying medical condition with fatal outcome using European Union data from 2009 to 2017. Results: Of 13 368 cases included in the basic dataset, 2806 (21%) were fatal. Age ≥40 years and infection with influenza A virus were associated with fatal outcome. Of 5886 cases with known underlying medical conditions and virus A subtype included in a more detailed analysis, 1349 (23%) were fatal. Influenza virus A(H1N1)pdm09 or A(H3N2) infection, age ≥60 years, cancer, human immunodeficiency virus infection and/or other immune deficiency, and heart, kidney, and liver disease were associated with fatal outcome; the risk of death was lower for patients with chronic lung disease and for pregnant women. Conclusions: This study re-emphasises the importance of preventing influenza in the elderly and tailoring strategies to risk groups with underlying medical conditions.
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$a Gomes Dias, Joana $u Surveillance and Response Support, European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.
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$a Bonmarin, Isabelle $u Bruno Hubert, Santé Public France, Saint-Maurice Cedex, France.
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$a Hubert, Bruno $u Bruno Hubert, Santé Public France, Saint-Maurice Cedex, France.
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$a Larrauri, Amparo $u National Centre of Epidemiology, CIBER Epidemiología y Salud Pública, Institute of Health Carlos III (ISCIII), Madrid, Spain.
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$a Oliva Domínguez, Jesús A $u National Centre of Epidemiology, CIBER Epidemiología y Salud Pública, Institute of Health Carlos III (ISCIII), Madrid, Spain.
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$a Brytting, Mia $u The Public Health Agency of Sweden, Solna, Sweden.
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$a Carnahan, Annasara $u The Public Health Agency of Sweden, Solna, Sweden.
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$a Popovici, Odette $u National Institute of Public Health, Romania National Centre for Communicable Diseases Surveillance and Control, Bucuresti, Romania.
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$a Lupulescu, Emilia $u National Institute of Public Health, Romania National Centre for Communicable Diseases Surveillance and Control, Bucuresti, Romania.
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$a O'Donnell, Joan $u Health Service Executive-Health Protection Surveillance Centre, Dublin, Ireland.
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$a Domegan, Lisa $u Health Service Executive-Health Protection Surveillance Centre, Dublin, Ireland.
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$a Van Gageldonk-Lafeber, Arianne B $u National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
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$a Meijer, Adam $u National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
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$a Kynčl, Jan $u Department of Infectious Diseases Epidemiology, National Institute of Public Health, Prague, Czech Republic.
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$a Slezák, Pavel $u Department of Infectious Diseases Epidemiology, National Institute of Public Health, Prague, Czech Republic.
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$a Guiomar, Raquel $u Instituto Nacional de Saúde Doutor Ricardo Jorge (National Institute of Health Dr. Ricardo Jorge), Lisboa, Portugal.
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$a Orta Gomes, Carlos M $u Department of Public Health of Regional Health Administration of Lisbon and Tagus Valley, Lisboa, Portugal.
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$a Popow-Kraupp, Theresia $u Medical University of Vienna, Center for Virology, Vienna, Austria.
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$a Mikas, Ján $u Public Health Authority of the Slovak Republic, Bratislava, Slovakia.
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$a Melillo, Jackie M $u Infectious Disease Prevention and Control Unit, Health Regulation, Malta.
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$a Melillo, Tanya $u Infectious Disease Prevention and Control Unit, Health Regulation, Malta.
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$a Ikonen, Niina $u Department of Health Security, National Institute for Health and Welfare (THL), Helsinki, Finland.
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$a Lyytikäinen, Outi $u Department of Health Security, National Institute for Health and Welfare (THL), Helsinki, Finland.
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$a Snacken, René $u Surveillance and Response Support, European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.
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$a Penttinen, Pasi $u Office of the Chief Scientist, European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.
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