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Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

RS. Patel, AF. Schmidt, V. Tragante, RO. McCubrey, MV. Holmes, LJ. Howe, K. Direk, A. Åkerblom, K. Leander, SS. Virani, KA. Kaminski, JD. Muehlschlegel, MP. Dubé, H. Allayee, P. Almgren, M. Alver, EV. Baranova, H. Behlouli, B. Boeckx, PS. Braund,...

. 2019 ; 12 (4) : e002471. [pub] 20190321

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, metaanalýza, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20022798

Grantová podpora
PG/18/50/33837 British Heart Foundation - United Kingdom
PG/18/5033837 British Heart Foundation - United Kingdom
U01 GM074492 NIGMS NIH HHS - United States
Department of Health - United Kingdom
085475/B/08/Z Wellcome Trust - United Kingdom
P01 HL076491 NHLBI NIH HHS - United States
084727/Z/08/Z Wellcome Trust - United Kingdom
Medical Research Council - United Kingdom
P50 HL077113 NHLBI NIH HHS - United States
RG/14/5/30893 British Heart Foundation - United Kingdom
072960/Z/03/Z Wellcome Trust - United Kingdom
085475/Z/08/Z Wellcome Trust - United Kingdom
R01 NR013396 NINR NIH HHS - United States
FS/14/76/30933 British Heart Foundation - United Kingdom
084726/Z/08/Z Wellcome Trust - United Kingdom
FS/18/23/33512 British Heart Foundation - United Kingdom
PCL/17/07 Chief Scientist Office - United Kingdom
R01 HL074730 NHLBI NIH HHS - United States
CIHR - Canada
R01 HL133169 NHLBI NIH HHS - United States

BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/myocardial infarction), occurred in 13 040 of the 93 115 participants with available outcome data. Effect estimates were compared with case/control risk obtained from the CARDIoGRAMplusC4D consortium (Coronary Artery Disease Genome-wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) including 47 222 CHD cases and 122 264 controls free of CHD. RESULTS: Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline (GENIUS-CHD odds ratio, 1.02; 95% CI, 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D odds ratio 1.20; 95% CI, 1.18-1.22; P for interaction <0.001 compared with the GENIUS-CHD estimate. Similarly, no clear associations were identified for additional subsequent outcomes, including all-cause death, although we found a modest positive association between chromosome 9p21 and subsequent revascularization (odds ratio, 1.07; 95% CI, 1.04-1.09). CONCLUSIONS: In contrast to studies comparing individuals with CHD to disease-free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development.

5th Department of Medicine Medical Faculty Mannheim Heidelberg University Mannheim Germany

AMC Heart Center

ATS Sardegna ASL 3 Nuoro

BHF Cardiovascular Research Centre Glenfield Hospital Leicester United Kingdom

CARDIoGRAMPlusC4D University of Groningen University Medical Center Groningen Netherlands

Cardiology Centre Institute for Clinical and Experimental Medicine Prague Czech Republic

Cardiology Department Parma University Hospital Italy

Cardiovascular Research Center and Center for Human Genetic Research Massachusetts General Hospital Boston and Program in Medical and Population Genetics Broad Institute Cambridge MA

Cardiovascular Sciences University of Edinburgh

Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec

Centre for Experimental Medicine Institut for Clinical and Experimental Medicine Prague Czech Republic

Centre for Outcomes Research and Evaluation Research Institute of the McGill University Health Centre

Centro de Pesquisa Clinica Hospital Universitario Universidade de Sao Paulo Brazil

Clinica Mediterranea Naples Italy

Clinical Epidemiology and Biostatistics

Clinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population Health University of Oxford United Kingdom

CNR Institute of Clinical Physiology Pisa Italy

Departement of Cardiovascular Sciences KU Leuven Belgium

Department of Anesthesiology Perioperative and Pain Medicine Brigham and Women's Hospital

Department of Biomedical Sciences Humanitas University Milan Italy

Department of Biostatistics and Epidemiology Texas Heart Institute Houston

Department of Biotechnology Institute of Molecular and Cell Biology University of Tartu Estonia

Department of Cardio Thoracic Surgery

Department of Cardio Thoracic Surgery Finnish Cardiovascular Research Center Faculty of Medicine and Life Sciences University of Tampere

Department of Cardiology

Department of Cardiology and Internal Diseases Military Institute of Medicine Warsaw Poland

Department of Cardiology Clinical Sciences Lund University and Skåne University Hospital Lund University Lund Sweden

Department of Cardiology Medical University of Warsaw Poland

Department of Cardiovascular Medicine Humanitas Clinical and Research Center Milan Italy

Department of Cardiovascular Medicine University of Münster Germany

Department of Cardiovascular Sciences and Department of Health Sciences University of Leicester United Kingdom

Department of Cardiovascular Sciences Glenfield Hospital Leicester United Kingdom

Department of Cellular and Molecular Medicine Lerner Research Institute

Department of Clinical Chemistry

Department of Clinical Chemistry and Hematology

Department of Clinical Chemistry UMC Utrecht Netherlands

Department of Clinical Physiology

Department of Clinical Sciences Lund University Malmö Sweden

Department of Epidemiology Emory University Rollins School of Public Health

Department of Forensic Medicine Medical University of Bialystok Poland

Department of Genetics Statistical Genomics Division

Department of Internal Medicine Jagiellonian University Medical College Kraków Poland

Department of Medical Genetics

Department of Medicine and Cardiology Academic Teaching Hospital Feldkirch Austria Heart Center Leipzig

Department of Medicine University of Verona Italy

Department of Neurology and Neurosurgery Brain Centre Rudolf Magnus and Julius Center for Health Sciences and Primary Care University Medical Center Utrecht the Netherlands

Department of Pathology and Molecular Medicine McMaster University

Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics

Department of Population Medicine and Civilization Disease Prevention

Department of Radiology University Medical Center Utrecht the Netherlands

Department of Vascular Medicine Academic Medical Center Amsterdam the Netherlands

Department of Vascular Medicine University Medical Center Utrecht and Utrecht University the Netherlands

Department of Vascular Surgery University Medical Center Utrecht University Utrecht the Netherlands

Departments of Preventive Medicine and Biochemistry and Molecular Medicine Keck School of Medicine of USC Los Angeles CA

Division Heart and Lungs Department of Cardiology

Division of Cardiology Department of Medicine Emory Clinical Cardiovascular Research Institute Emory University School of Medicine Atlanta GA

Division of Cardiovascular Medicine College of Medicine University of Florida

Division of Clinical Epidemiology and Aging Research German Cancer Research Center

Division of Molecular and Clinical Medicine School of Medicine University of Dundee Scotland United Kingdom

Division of Pharmacoepidemiology and Clinical Pharmacology

Division of Pharmacoepidemiology and Clinical Pharmacology University Medical Center Utrecht the Netherlands

Durrer Centre of Cardiogenetic Research ICIN Netherlands Heart Institute Netherlands

Emeritus Professor of Cardiology University of Edinburgh

Estonian Genome Center Institute of Genomics

Harvard Medical School Boston MA

Heart and Lung Center Helsinki University Hospital University of Helsinki Finland

Heart Health Research Group University of Auckland New Zealand

Heart Institute University of Sao Paulo Brazil

Institute for Biomedicine Eurac Research Affiliated Institute of the University of Lübeck Bolzano Italy

Institute of Cardiovascular and Medical Sciences University of Glasgow United Kingdom

Institute of Cardiovascular Science Faculty of Population Health Science

Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden

Institute of Health Informatics Faculty of Population Health Science University College London United Kingdom

Intermountain Heart Institute Intermountain Medical Center Salt Lake City UT

Julius Center for Health Sciences and Primary Care University Medical Center Utrecht the Netherlands

Laboratory for Translational Genetics Department of Human Genetics

Laboratory of Clinical Chemistry and Hematology Division Laboratories Pharmacy and Biomedical Genetics

Laboratory of Experimental Cardiology

LIFE Research Center for Civilization Diseases

Montreal Heart Institute

Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics Division of Molecular and Clinical Medicine Ninewells Hospital and Medical School Dundee

Research Institute of the McGill University Health Centre

Respiratory Oncology Unit Department of Respiratory Medicine University Hospitals KU Leuven Belgium

Robertson Center for Biostatistics

Ruddy Canadian Cardiovascular Genetics Centre

Saint Luke's Mid America Heart Institute and the University of Missouri Kansas City and Saint Luke's Health System Kansas City MO

Section of Cardiology Michael E DeBakey Veterans Affairs Medical Center Section of Cardiovascular Research and Department of Medicine Baylor College of Medicine Houston TX

Section of Gerontology and Geriatrics Department of Internal Medicine Leiden University Medical Center

Service de cardiologie Département multidisciplinaire de cardiologie Instituteitut universitaire de cardiologie et de pneumologie de Québec Canada

St Antonius Hospital Department of Cardiology Nieuwegein the Netherlands

The Christchurch Heart Institute University of Otago Christchurch New Zealand

Transplantation Laboratory Medicum

Université de Montréal QC Canada

University of Ottawa Heart Institute

University of Texas School of Public Health Houston

Uppsala Clinical Research Center Uppsala University Sweden

Vorarlberg Institute for Vascular Investigation and Treatment

William Harvey Research Institute Barts and the London Medical School Queen Mary University of London

Citace poskytuje Crossref.org

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$a Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events / $c RS. Patel, AF. Schmidt, V. Tragante, RO. McCubrey, MV. Holmes, LJ. Howe, K. Direk, A. Åkerblom, K. Leander, SS. Virani, KA. Kaminski, JD. Muehlschlegel, MP. Dubé, H. Allayee, P. Almgren, M. Alver, EV. Baranova, H. Behlouli, B. Boeckx, PS. Braund, LP. Breitling, G. Delgado, NE. Duarte, L. Dufresne, N. Eriksson, L. Foco, CM. Gijsberts, Y. Gong, J. Hartiala, M. Heydarpour, JA. Hubacek, M. Kleber, D. Kofink, P. Kuukasjärvi, VV. Lee, A. Leiherer, PA. Lenzini, D. Levin, LP. Lyytikäinen, N. Martinelli, U. Mons, CP. Nelson, K. Nikus, AP. Pilbrow, R. Ploski, YV. Sun, MWT. Tanck, WHW. Tang, S. Trompet, SW. van der Laan, J. van Setten, RO. Vilmundarson, C. Viviani Anselmi, E. Vlachopoulou, E. Boerwinkle, C. Briguori, JF. Carlquist, KF. Carruthers, G. Casu, J. Deanfield, P. Deloukas, F. Dudbridge, N. Fitzpatrick, B. Gigante, S. James, ML. Lokki, PA. Lotufo, N. Marziliano, IR. Mordi, JB. Muhlestein, C. Newton Cheh, J. Pitha, CH. Saely, A. Samman-Tahhan, PB. Sandesara, A. Teren, A. Timmis, F. Van de Werf, E. Wauters, AAM. Wilde, I. Ford, DJ. Stott, A. Algra, MG. Andreassi, D. Ardissino, BJ. Arsenault, CM. Ballantyne, TO. Bergmeijer, CR. Bezzina, SC. Body, P. Bogaty, GJ. de Borst, H. Brenner, R. Burkhardt, C. Carpeggiani, G. Condorelli, RM. Cooper-DeHoff, S. Cresci, U. de Faire, RN. Doughty, H. Drexel, JC. Engert, KAA. Fox, D. Girelli, E. Hagström, SL. Hazen, C. Held, H. Hemingway, IE. Hoefer, GK. Hovingh, JA. Johnson, PA. de Jong, JW. Jukema, MP. Kaczor, M. Kähönen, J. Kettner, M. Kiliszek, OH. Klungel, B. Lagerqvist, D. Lambrechts, JO. Laurikka, T. Lehtimäki, D. Lindholm, BK. Mahmoodi, AH. Maitland-van der Zee, R. McPherson, O. Melander, A. Metspalu, W. Pepinski, O. Olivieri, G. Opolski, CN. Palmer, G. Pasterkamp, CJ. Pepine, AC. Pereira, L. Pilote, AA. Quyyumi, AM. Richards, M. Sanak, M. Scholz, A. Siegbahn, J. Sinisalo, JG. Smith, JA. Spertus, AFR. Stewart, W. Szczeklik, A. Szpakowicz, JM. Ten Berg, G. Thanassoulis, J. Thiery, Y. van der Graaf, FLJ. Visseren, J. Waltenberger, CARDIoGRAMPlusC4D Consortium, P. Van der Harst, JC. Tardif, N. Sattar, CC. Lang, G. Pare, JM. Brophy, JL. Anderson, W. März, L. Wallentin, VA. Cameron, BD. Horne, NJ. Samani, AD. Hingorani, FW. Asselbergs,
520    9_
$a BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/myocardial infarction), occurred in 13 040 of the 93 115 participants with available outcome data. Effect estimates were compared with case/control risk obtained from the CARDIoGRAMplusC4D consortium (Coronary Artery Disease Genome-wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) including 47 222 CHD cases and 122 264 controls free of CHD. RESULTS: Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline (GENIUS-CHD odds ratio, 1.02; 95% CI, 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D odds ratio 1.20; 95% CI, 1.18-1.22; P for interaction <0.001 compared with the GENIUS-CHD estimate. Similarly, no clear associations were identified for additional subsequent outcomes, including all-cause death, although we found a modest positive association between chromosome 9p21 and subsequent revascularization (odds ratio, 1.07; 95% CI, 1.04-1.09). CONCLUSIONS: In contrast to studies comparing individuals with CHD to disease-free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development.
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700    1_
$a Schmidt, Amand F $u Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.). Division Heart and Lungs, Department of Cardiology (A.F.S., V.T. D.K., F.W.A.).
700    1_
$a Tragante, Vinicius $u Division Heart and Lungs, Department of Cardiology (A.F.S., V.T. D.K., F.W.A.).
700    1_
$a McCubrey, Raymond O $u Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A.).
700    1_
$a Holmes, Michael V $u Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health (M.V.H.), University of Oxford, United Kingdom. Medical Research Council Population Health Research Unit (M.V.H.), University of Oxford, United Kingdom. National Institute for Health Research Oxford Biomedical Research Centre (M.V.H.), University of Oxford, United Kingdom.
700    1_
$a Howe, Laurence J $u Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
700    1_
$a Direk, Kenan $u Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
700    1_
$a Åkerblom, Axel $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden. Department of Medical Sciences, Cardiology (A.A., E.H., C.H., D. Lindholm), Uppsala University, Sweden.
700    1_
$a Leander, Karin $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., U.d.F.).
700    1_
$a Virani, Salim S $u Section of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center, Section of Cardiovascular Research, and Department of Medicine, Baylor College of Medicine, Houston, TX (S.S.V., C.M.B.).
700    1_
$a Kaminski, Karol A $u Department of Population Medicine and Civilization Disease Prevention (K.A.K.). Department of Cardiology (K.A.K., A. Szpakowicz).
700    1_
$a Muehlschlegel, Jochen D $u Harvard Medical School, Boston, MA (J.D.M., M.H. S.C.B.).
700    1_
$a Dubé, Marie-Pierre $u Université de Montréal, QC, Canada (M.-P.D.).
700    1_
$a Allayee, Hooman $u Departments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of USC, Los Angeles, CA.
700    1_
$a Almgren, Peter $u Department of Clinical Sciences, Lund University, Malmö, Sweden (P.A., O.M.).
700    1_
$a Alver, Maris $u Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Estonia (M.A., A.M.).
700    1_
$a Baranova, Ekaterina V $u Division of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), University Medical Center Utrecht, the Netherlands.
700    1_
$a Behlouli, Hassan $u Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (H.B., L.D., L.P., J.M.B.).
700    1_
$a Boeckx, Bram $u Laboratory for Translational Genetics, Department of Human Genetics (B.B., D. Lambrechts). Laboratory for Translational Genetics, VIB Center for Cancer Biology, VIB, Belgium (B.B., D. Lambrechts).
700    1_
$a Braund, Peter S $u Department of Cardiovascular Sciences (P.S.B., C.P.N., N.J.S.) and Department of Health Sciences, University of Leicester, United Kingdom. National Institute of Health Research (NIHR) Leicester Biomedical Research Centre (P.S.B., C.P.N.), Glenfield Hospital, Leicester, United Kingdom.
700    1_
$a Breitling, Lutz P $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M., H.B.).
700    1_
$a Delgado, Graciela $u Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (G.D., M. Kleber, W.M.).
700    1_
$a Duarte, Nubia E $u Heart Institute, University of Sao Paulo, Brazil (N.E.D., A.C.P.).
700    1_
$a Dufresne, Line $u Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (H.B., L.D., L.P., J.M.B.). Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, QC, Canada (L.D., J.C.E., G.T.).
700    1_
$a Eriksson, Niclas $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden.
700    1_
$a Foco, Luisa $u Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (L.F.).
700    1_
$a Gijsberts, Crystel M $u Laboratory of Experimental Cardiology (C.M.G., B.D.H.).
700    1_
$a Gong, Yan $u Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.).
700    1_
$a Hartiala, Jaana $u Departments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of USC, Los Angeles, CA. Institute for Genetic Medicine (J.H.), Keck School of Medicine of USC, Los Angeles, CA.
700    1_
$a Heydarpour, Mahyar $u Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (M.H.). Harvard Medical School, Boston, MA (J.D.M., M.H. S.C.B.).
700    1_
$a Hubacek, Jaroslav A $u Centre for Experimental Medicine, Institut for Clinical and Experimental Medicine, Prague, Czech Republic (J.A.H., J.P.).
700    1_
$a Kleber, Marcus $u Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (G.D., M. Kleber, W.M.).
700    1_
$a Kofink, Daniel $u Division Heart and Lungs, Department of Cardiology (A.F.S., V.T. D.K., F.W.A.).
700    1_
$a Kuukasjärvi, Pekka $u Department of Cardio-Thoracic Surgery (P.K.).
700    1_
$a Lee, Vei-Vei $u Department of Biostatistics and Epidemiology, Texas Heart Institute, Houston (V.-V.L.).
700    1_
$a Leiherer, Andreas $u Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A.L., C.H.S., H.D.). Private University of the Principality of Liechtenstein, Triesen, Liechtenstein (A.L., C.H.S., H.D.). Medical Central Laboratories, Feldkirch, Austria (A.L.).
700    1_
$a Lenzini, Petra A $u Department of Genetics, Statistical Genomics Division (P.A.L., S.C.).
700    1_
$a Levin, Daniel $u Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
700    1_
$a Lyytikäinen, Leo-Pekka $u Department of Clinical Chemistry (L.-P.L., T.L.). Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.).
700    1_
$a Martinelli, Nicola $u Department of Medicine, University of Verona, Italy (N. Martinelli, D.G., O.O.).
700    1_
$a Mons, Ute $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M., H.B.).
700    1_
$a Nelson, Christopher P $u Department of Cardiovascular Sciences (P.S.B., C.P.N., N.J.S.) and Department of Health Sciences, University of Leicester, United Kingdom. National Institute of Health Research (NIHR) Leicester Biomedical Research Centre (P.S.B., C.P.N.), Glenfield Hospital, Leicester, United Kingdom.
700    1_
$a Nikus, Kjell $u Department of Cardiology (K.N.). Department of Cardiology, Heart Center (K.N.).
700    1_
$a Pilbrow, Anna P $u The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.B., A.M.R., V.A.C.).
700    1_
$a Ploski, Rafal $u Department of Medical Genetics (R.P.).
700    1_
$a Sun, Yan V $u Department of Epidemiology, Emory University Rollins School of Public Health (Y.V.S.). Department of Biomedical Informatics (Y.V.S.).
700    1_
$a Tanck, Michael W T $u Clinical Epidemiology and Biostatistics (M.W.T.T.).
700    1_
$a Tang, W H Wilson $u Department of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.). Department of Cardiovascular Medicine, Heart and Vascular Institute and Center for Clinical Genomics (W.H.W.T.).
700    1_
$a Trompet, Stella $u Section of Gerontology and Geriatrics, Department of Internal Medicine (S.T.), Leiden University Medical Center. Department of Cardiology (S.T., J.W.J.), Leiden University Medical Center.
700    1_
$a van der Laan, Sander W $u Laboratory of Clinical Chemistry and Hematology, Division Laboratories, Pharmacy, and Biomedical Genetics (S.W.v.d.L.).
700    1_
$a van Setten, Jessica $u Durrer Centre of Cardiogenetic Research, ICIN-Netherlands Heart Institute, Netherlands (J.v.S., F.W.B.).
700    1_
$a Vilmundarson, Ragnar O $u Ruddy Canadian Cardiovascular Genetics Centre (R.O.V., A.F.R.S.). Department of Biochemistry, Microbiology and Immunology (R.O.V., A.F.R.S.).
700    1_
$a Viviani Anselmi, Chiara $u Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Milan, Italy (C.V.A., G.C).
700    1_
$a Vlachopoulou, Efthymia $u Transplantation Laboratory, Medicum (E.V., M.-L.L.).
700    1_
$a Boerwinkle, Eric $u University of Texas School of Public Health, Houston (E.B.).
700    1_
$a Briguori, Carlo $u Clinica Mediterranea, Naples, Italy (C.B.).
700    1_
$a Carlquist, John F $u Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A.). Cardiology Division, Department of Internal Medicine (J.F.C., J.B.M., J.L.A.).
700    1_
$a Carruthers, Kathryn F $u Cardiovascular Sciences (K.F.C.), University of Edinburgh.
700    1_
$a Casu, Gavino $u Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Milan, Italy (C.V.A., G.C). ATS Sardegna, ASL 3, Nuoro (G. Casu, N. Marziliano).
700    1_
$a Deanfield, John $u Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.). Bart's Heart Centre, St Bartholomew's Hospital, London, United Kingdom (R.S.P., J.D., A. Timmis).
700    1_
$a Deloukas, Panos $u William Harvey Research Institute, Barts and the London Medical School (P.D.), Queen Mary University of London. Centre for Genomic Health (P.D.), Queen Mary University of London.
700    1_
$a Dudbridge, Frank $u BHF Cardiovascular Research Centre (F.D.), Glenfield Hospital, Leicester, United Kingdom.
700    1_
$a Fitzpatrick, Natalie $u Institute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.).
700    1_
$a Gigante, Bruna $u Department of Clinical Chemistry and Hematology (B.G., I.E.H.).
700    1_
$a James, Stefan $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden. Department of Medical Sciences, Cardiology (S.J., B.L., L.W.), Uppsala University, Sweden.
700    1_
$a Lokki, Marja-Liisa $u Transplantation Laboratory, Medicum (E.V., M.-L.L.).
700    1_
$a Lotufo, Paulo A $u Centro de Pesquisa Clinica, Hospital Universitario, Universidade de Sao Paulo, Brazil (P.A.L.).
700    1_
$a Marziliano, Nicola $u ATS Sardegna, ASL 3, Nuoro (G. Casu, N. Marziliano).
700    1_
$a Mordi, Ify R $u Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
700    1_
$a Muhlestein, Joseph B $u Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A.). Cardiology Division, Department of Internal Medicine (J.F.C., J.B.M., J.L.A.).
700    1_
$a Newton Cheh, Chris $u Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (C.N.C.).
700    1_
$a Pitha, Jan $u Centre for Experimental Medicine, Institut for Clinical and Experimental Medicine, Prague, Czech Republic (J.A.H., J.P.).
700    1_
$a Saely, Christoph H $u Institute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.). Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A.L., C.H.S., H.D.). Private University of the Principality of Liechtenstein, Triesen, Liechtenstein (A.L., C.H.S., H.D.).
700    1_
$a Samman-Tahhan, Ayman $u Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA (A.S.-T., P.B.S., A.A.Q.).
700    1_
$a Sandesara, Pratik B $u Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA (A.S.-T., P.B.S., A.A.Q.).
700    1_
$a Teren, Andrej $u Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Austria. Heart Center Leipzig (A. Teren). LIFE Research Center for Civilization Diseases (A. Teren, R.B., M. Scholz, J.T.).
700    1_
$a Timmis, Adam $u Institute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.). Bart's Heart Centre, St Bartholomew's Hospital, London, United Kingdom (R.S.P., J.D., A. Timmis).
700    1_
$a Van de Werf, Frans $u Departement of Cardiovascular Sciences, KU Leuven, Belgium (F.V.d.W.).
700    1_
$a Wauters, Els $u Respiratory Oncology Unit, Department of Respiratory Medicine, University Hospitals KU Leuven, Belgium (E.W.).
700    1_
$a Wilde, Arthur A M $u AMC Heart Center (A.A.M.W., C.R.B.). Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia (A.A.M.W.).
700    1_
$a Ford, Ian $u Robertson Center for Biostatistics (I.F.).
700    1_
$a Stott, David J $u Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (D.J.S., N.S.).
700    1_
$a Algra, Ale $u Department of Neurology and Neurosurgery, Brain Centre Rudolf Magnus and Julius Center for Health Sciences and Primary Care (A. Algra), University Medical Center Utrecht, the Netherlands.
700    1_
$a Andreassi, Maria G $u CNR Institute of Clinical Physiology, Pisa, Italy (M.G.A., C.C.).
700    1_
$a Ardissino, Diego $u Cardiology Department, Parma University Hospital, Italy (D.A.).
700    1_
$a Arsenault, Benoit J $u Centre de recherche de l'Institut Universitaire de cardiologie et de pneumologie de Québec (B.J.A.). Department of Medicine, Faculty of Medicine, Université Laval, Canada (B.J.A.).
700    1_
$a Ballantyne, Christie M $u Section of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center, Section of Cardiovascular Research, and Department of Medicine, Baylor College of Medicine, Houston, TX (S.S.V., C.M.B.).
700    1_
$a Bergmeijer, Thomas O $u St. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
700    1_
$a Bezzina, Connie R $u AMC Heart Center (A.A.M.W., C.R.B.).
700    1_
$a Body, Simon C $u Harvard Medical School, Boston, MA (J.D.M., M.H. S.C.B.). Department of Anesthesia, Pain and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA (S.C.B.).
700    1_
$a Bogaty, Peter $u Service de cardiologie, Département multidisciplinaire de cardiologie, Instituteitut universitaire de cardiologie et de pneumologie de Québec, Canada (P.B.). Unité d'évaluation cardiovasculaire, Institut national d'excellence en santé et en services sociaux (INESSS), Montreal Canada (P.B.). Instituteitut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec City, Canada (P.B.).
700    1_
$a de Borst, Gert J $u Department of Vascular Surgery, University Medical Center Utrecht, University Utrecht, the Netherlands (G.J.d.B.).
700    1_
$a Brenner, Hermann $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg (L.P.B., U.M., H.B.).
700    1_
$a Burkhardt, Ralph $u LIFE Research Center for Civilization Diseases (A. Teren, R.B., M. Scholz, J.T.). Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Germany (R.B.).
700    1_
$a Carpeggiani, Clara $u CNR Institute of Clinical Physiology, Pisa, Italy (M.G.A., C.C.).
700    1_
$a Condorelli, Gianluigi $u Department of Biomedical Sciences, Humanitas University, Milan, Italy (G. Condorelli).
700    1_
$a Cooper-DeHoff, Rhonda M $u Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.).
700    1_
$a Cresci, Sharon $u Department of Genetics, Statistical Genomics Division (P.A.L., S.C.). Department of Medicine, Cardiovascular Division Washington University School of Medicine, St Louis, MO (S.C.).
700    1_
$a de Faire, Ulf $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (K.L., U.d.F.).
700    1_
$a Doughty, Robert N $u Heart Health Research Group, University of Auckland, New Zealand (R.N.D.).
700    1_
$a Drexel, Heinz $u Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria (A.L., C.H.S., H.D.). Private University of the Principality of Liechtenstein, Triesen, Liechtenstein (A.L., C.H.S., H.D.). Drexel University College of Medicine, Philadelphia, PA (H.D.).
700    1_
$a Engert, James C $u Research Institute of the McGill University Health Centre (J.C.E.). Division of Cardiology, Department of Medicine, Royal Victoria Hospital (J.C.E., G.T.). Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, QC, Canada (L.D., J.C.E., G.T.).
700    1_
$a Fox, Keith A A $u Emeritus Professor of Cardiology (K.A.A.F.), University of Edinburgh.
700    1_
$a Girelli, Domenico $u Department of Medicine, University of Verona, Italy (N. Martinelli, D.G., O.O.).
700    1_
$a Hagström, Emil $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden. Department of Medical Sciences, Cardiology (A.A., E.H., C.H., D. Lindholm), Uppsala University, Sweden.
700    1_
$a Hazen, Stanley L $u Department of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.). Department of Cardiovascular Medicine, Heart and Vascular Institute and Center for Microbiome and Human Health, Cleveland Clinic, OH (S.L.H.).
700    1_
$a Held, Claes $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden. Department of Medical Sciences, Cardiology (A.A., E.H., C.H., D. Lindholm), Uppsala University, Sweden.
700    1_
$a Hemingway, Harry $u Institute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.).
700    1_
$a Hoefer, Imo E $u Department of Clinical Chemistry and Hematology (B.G., I.E.H.).
700    1_
$a Hovingh, G Kees $u Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands (G.K.H.).
700    1_
$a Johnson, Julie A $u Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D., J.A.J.). Division of Cardiovascular Medicine, College of Medicine, University of Florida (J.A.J., C.J.P.).
700    1_
$a de Jong, Pim A $u Department of Radiology (P.A.d.J.), University Medical Center Utrecht, the Netherlands.
700    1_
$a Jukema, J Wouter $u Department of Cardiology (S.T., J.W.J.), Leiden University Medical Center. Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden (J.W.J.). Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands (J.W.J.).
700    1_
$a Kaczor, Marcin P $u Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M. Sanak, W.S.).
700    1_
$a Kähönen, Mika $u Department of Clinical Physiology (M. Kähönen). Department of Clinical Physiology (M. Kähönen).
700    1_
$a Kettner, Jiri $u Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic (J.K.).
700    1_
$a Kiliszek, Marek $u Department of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland (M. Kiliszek).
700    1_
$a Klungel, Olaf H $u Division of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), University Medical Center Utrecht, the Netherlands.
700    1_
$a Lagerqvist, Bo $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden. Department of Medical Sciences, Cardiology (S.J., B.L., L.W.), Uppsala University, Sweden.
700    1_
$a Lambrechts, Diether $u Laboratory for Translational Genetics, Department of Human Genetics (B.B., D. Lambrechts). Laboratory for Translational Genetics, VIB Center for Cancer Biology, VIB, Belgium (B.B., D. Lambrechts).
700    1_
$a Laurikka, Jari O $u Department of Cardio-Thoracic Surgery, Finnish Cardiovascular Research Center, Faculty of Medicine and Life Sciences, University of Tampere (J.O.L.). Department of Cardio-Thoracic Surgery, Heart Center, Tampere University Hospital, Finland (J.O.L).
700    1_
$a Lehtimäki, Terho $u Department of Clinical Chemistry (L.-P.L., T.L.). Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.).
700    1_
$a Lindholm, Daniel $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden. Department of Medical Sciences, Cardiology (A.A., E.H., C.H., D. Lindholm), Uppsala University, Sweden.
700    1_
$a Mahmoodi, Bakhtawar K $u St. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
700    1_
$a Maitland-van der Zee, Anke H $u Division of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), University Medical Center Utrecht, the Netherlands. Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, the Netherlands (A.H.M.-v.d.Z.).
700    1_
$a McPherson, Ruth $u University of Ottawa Heart Institute (R.M.). Departments of Medicine and Biochemistry, Microbiology and Immunology, University of Ottawa, ON, Canada (R.M.).
700    1_
$a Melander, Olle $u Department of Clinical Sciences, Lund University, Malmö, Sweden (P.A., O.M.). Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden (O.M.).
700    1_
$a Metspalu, Andres $u Estonian Genome Center, Institute of Genomics (A.M.). Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Estonia (M.A., A.M.).
700    1_
$a Pepinski, Witold $u Department of Forensic Medicine, Medical University of Bialystok, Poland (W.P., G.T.).
700    1_
$a Olivieri, Oliviero $u Department of Medicine, University of Verona, Italy (N. Martinelli, D.G., O.O.).
700    1_
$a Opolski, Grzegorz $u Department of Cardiology, Medical University of Warsaw, Poland (G.O.).
700    1_
$a Palmer, Colin N $u Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee (C.N.P.).
700    1_
$a Pasterkamp, Gerard $u Department of Clinical Chemistry, UMC Utrecht, Netherlands (G. Pasterkamp).
700    1_
$a Pepine, Carl J $u Division of Cardiovascular Medicine, College of Medicine, University of Florida (J.A.J., C.J.P.).
700    1_
$a Pereira, Alexandre C $u Heart Institute, University of Sao Paulo, Brazil (N.E.D., A.C.P.).
700    1_
$a Pilote, Louise $u Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (H.B., L.D., L.P., J.M.B.). Department of Medicine (L.P., J.M.B.).
700    1_
$a Quyyumi, Arshed A $u Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA (A.S.-T., P.B.S., A.A.Q.).
700    1_
$a Richards, A Mark $u The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.B., A.M.R., V.A.C.). Cardiovascular Research Institute, National University of Singapore (A.M.R.).
700    1_
$a Sanak, Marek $u Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M. Sanak, W.S.).
700    1_
$a Scholz, Markus $u LIFE Research Center for Civilization Diseases (A. Teren, R.B., M. Scholz, J.T.). Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Germany (M. Scholz).
700    1_
$a Siegbahn, Agneta $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden. Department of Medical Sciences, Clinical Chemistry (A. Siegbahn), Uppsala University, Sweden.
700    1_
$a Sinisalo, Juha $u Heart and Lung Center, Helsinki University Hospital University of Helsinki, Finland (J.S.).
700    1_
$a Smith, J Gustav $u Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital (J.G.S.), Lund University, Lund, Sweden. Wallenberg Center for Molecular Medicine (J.G.S.), Lund University, Lund, Sweden. Lund University Diabetes Center (J.G.S.), Lund University, Lund, Sweden.
700    1_
$a Spertus, John A $u Saint Luke's Mid America Heart Institute and the University of Missouri-Kansas City and Saint Luke's Health System, Kansas City, MO (J.A.S.).
700    1_
$a Stewart, Alexandre F R $u Ruddy Canadian Cardiovascular Genetics Centre (R.O.V., A.F.R.S.). Department of Biochemistry, Microbiology and Immunology (R.O.V., A.F.R.S.).
700    1_
$a Szczeklik, Wojciech $u Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M. Sanak, W.S.).
700    1_
$a Szpakowicz, Anna $u Department of Cardiology (K.A.K., A. Szpakowicz).
700    1_
$a Ten Berg, Jurriën M $u St. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (T.O.B., B.K.M., J.M.t.B.).
700    1_
$a Thanassoulis, George $u Department of Forensic Medicine, Medical University of Bialystok, Poland (W.P., G.T.). Division of Cardiology, Department of Medicine, Royal Victoria Hospital (J.C.E., G.T.). Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, QC, Canada (L.D., J.C.E., G.T.).
700    1_
$a Thiery, Joachim $u LIFE Research Center for Civilization Diseases (A. Teren, R.B., M. Scholz, J.T.). Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig (J.T.).
700    1_
$a van der Graaf, Yolanda $u Julius Center for Health Sciences and Primary Care (Y.v.d.G.), University Medical Center Utrecht, the Netherlands.
700    1_
$a Visseren, Frank L J $u Department of Vascular Medicine, University Medical Center Utrecht and Utrecht University, the Netherlands (F.L.J.V.).
700    1_
$a Waltenberger, Johannes $u Department of Cardiovascular Medicine, University of Münster, Germany (J.W.).
700    1_
$a Van der Harst, Pim $u CARDIoGRAMPlusC4D. University of Groningen, University Medical Center, Groningen, Netherlands (P.V.d.H.).
700    1_
$a Tardif, Jean-Claude $u Montreal Heart Institute (J.-C.T.). Faculty of Medicine (J.-C.T.).
700    1_
$a Sattar, Naveed $u Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (D.J.S., N.S.).
700    1_
$a Lang, Chim C $u Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D. Levin, I.R.M., C.C.L.).
700    1_
$a Pare, Guillaume $u Department of Pathology and Molecular Medicine, McMaster University (G. Pare). Population Health Research Institute, Hamilton, ON, Canada (G. Pare).
700    1_
$a Brophy, James M $u Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (H.B., L.D., L.P., J.M.B.). Department of Medicine (L.P., J.M.B.).
700    1_
$a Anderson, Jeffrey L $u Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.M., J.F.C., J.B.M., J.L.A.). Cardiology Division, Department of Internal Medicine (J.F.C., J.B.M., J.L.A.).
700    1_
$a März, Winfried $u Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (G.D., M. Kleber, W.M.). Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany (W.M.). Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria (W.M.).
700    1_
$a Wallentin, Lars $u Uppsala Clinical Research Center (A.A., N.E., S.J., E.H., C.H., B.L., D. Lindholm, A. Siegbahn, L.W.), Uppsala University, Sweden. Department of Medical Sciences, Cardiology (S.J., B.L., L.W.), Uppsala University, Sweden.
700    1_
$a Cameron, Vicky A $u The Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.B., A.M.R., V.A.C.).
700    1_
$a Horne, Benjamin D $u Laboratory of Experimental Cardiology (C.M.G., B.D.H.). Department of Biomedical Informatics, University of Utah, Salt Lake City (B.D.H.).
700    1_
$a Samani, Nilesh J $u Department of Cardiovascular Sciences (P.S.B., C.P.N., N.J.S.) and Department of Health Sciences, University of Leicester, United Kingdom.
700    1_
$a Hingorani, Aroon D $u Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
700    1_
$a Asselbergs, Folkert W $u Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.). Institute of Health Informatics, Faculty of Population Health Science, University College London, United Kingdom (N.F., C.H.S., A. Timmis, H.H., F.W.A.). Division Heart and Lungs, Department of Cardiology (A.F.S., V.T. D.K., F.W.A.). Durrer Centre of Cardiogenetic Research, ICIN-Netherlands Heart Institute, Netherlands (J.v.S., F.W.B.).
710    2_
$a CARDIoGRAMPlusC4D Consortium
773    0_
$w MED00205617 $t Circulation. Genomic and precision medicine $x 2574-8300 $g Roč. 12, č. 4 (2019), s. e002471
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30897348 $y Pubmed
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990    __
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BMC    __
$a 2019 $b 12 $c 4 $d e002471 $e 20190321 $i 2574-8300 $m Circulation. Genomic and precision medicine $n Circ Genom Precis Med $x MED00205617
GRA    __
$a PG/18/50/33837 $p British Heart Foundation $2 United Kingdom
GRA    __
$a PG/18/5033837 $p British Heart Foundation $2 United Kingdom
GRA    __
$a U01 GM074492 $p NIGMS NIH HHS $2 United States
GRA    __
$p Department of Health $2 United Kingdom
GRA    __
$a 085475/B/08/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a P01 HL076491 $p NHLBI NIH HHS $2 United States
GRA    __
$a 084727/Z/08/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$p Medical Research Council $2 United Kingdom
GRA    __
$a P50 HL077113 $p NHLBI NIH HHS $2 United States
GRA    __
$a RG/14/5/30893 $p British Heart Foundation $2 United Kingdom
GRA    __
$a 072960/Z/03/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a 085475/Z/08/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a R01 NR013396 $p NINR NIH HHS $2 United States
GRA    __
$a FS/14/76/30933 $p British Heart Foundation $2 United Kingdom
GRA    __
$a 084726/Z/08/Z $p Wellcome Trust $2 United Kingdom
GRA    __
$a FS/18/23/33512 $p British Heart Foundation $2 United Kingdom
GRA    __
$a PCL/17/07 $p Chief Scientist Office $2 United Kingdom
GRA    __
$a R01 HL074730 $p NHLBI NIH HHS $2 United States
GRA    __
$p CIHR $2 Canada
GRA    __
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LZP    __
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