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Diagnostic Yield of Next-generation Sequencing in Very Early-onset Inflammatory Bowel Diseases: A Multicentre Study
F. Charbit-Henrion, M. Parlato, S. Hanein, R. Duclaux-Loras, J. Nowak, B. Begue, S. Rakotobe, J. Bruneau, C. Fourrage, O. Alibeu, F. Rieux-Laucat, E. Lévy, MC. Stolzenberg, F. Mazerolles, S. Latour, C. Lenoir, A. Fischer, C. Picard, M. Aloi, JA....
Journal of Crohn's and colitis.
2018 ;
12 (9) :
1104-1112.
[pub] 2018Aug29
Language English Country Great Britain
Document type Journal Article, Multicenter Study
Persistent link
https://www.medvik.cz/link/bmc20022972
Grant support
339407
European Research Council - International
- MeSH
- Child MeSH
- Inflammatory Bowel Diseases diagnosis etiology therapy MeSH
- Cohort Studies MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Predictive Value of Tests MeSH
- Child, Preschool MeSH
- Age of Onset MeSH
- High-Throughput Nucleotide Sequencing * MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
BACKGROUND AND AIMS: An expanding number of monogenic defects have been identified as causative of severe forms of very early-onset inflammatory bowel diseases [VEO-IBD]. The present study aimed at defining how next-generation sequencing [NGS] methods can be used to improve identification of known molecular diagnosis and to adapt treatment. METHODS: A total of 207 children were recruited in 45 paediatric centres through an international collaborative network [ESPGHAN GENIUS working group] with a clinical presentation of severe VEO-IBD [n = 185] or an anamnesis suggestive of a monogenic disorder [n = 22]. Patients were divided at inclusion into three phenotypic subsets: predominantly small bowel inflammation, colitis with perianal lesions, and colitis only. Methods to obtain molecular diagnosis included functional tests followed by specific Sanger sequencing, custom-made targeted NGS, and in selected cases whole exome sequencing [WES] of parents-child trios. Genetic findings were validated clinically and/or functionally. RESULTS: Molecular diagnosis was achieved in 66/207 children [32%]: 61% with small bowel inflammation, 39% with colitis and perianal lesions, and 18% with colitis only. Targeted NGS pinpointed gene mutations causative of atypical presentations, and identified large exonic copy number variations previously missed by WES. CONCLUSIONS: Our results lead us to propose an optimised diagnostic strategy to identify known monogenic causes of severe IBD.
Department of Gastroenterology Hôpital St Antoine Assistance Publique Hôpitaux de Paris Paris France
Department of Paediatrics Budapest Hungary
Department of Pediatrics Budapest Hungary
Inflammatory Bowel Disease Unit Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain
INSERM UMR 1163 Translational Genetic and Imagine Institute Paris France
References provided by Crossref.org
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- $a Charbit-Henrion, Fabienne $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Paediatric Gastroenterology, Hepatology and Nutrition Unit, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN].
- 245 10
- $a Diagnostic Yield of Next-generation Sequencing in Very Early-onset Inflammatory Bowel Diseases: A Multicentre Study / $c F. Charbit-Henrion, M. Parlato, S. Hanein, R. Duclaux-Loras, J. Nowak, B. Begue, S. Rakotobe, J. Bruneau, C. Fourrage, O. Alibeu, F. Rieux-Laucat, E. Lévy, MC. Stolzenberg, F. Mazerolles, S. Latour, C. Lenoir, A. Fischer, C. Picard, M. Aloi, JA. Dias, MB. Hariz, A. Bourrier, C. Breuer, A. Breton, J. Bronski, S. Buderus, M. Cananzi, S. Coopman, C. Crémilleux, A. Dabadie, C. Dumant-Forest, OE. Gurkan, A. Fabre, A. Fischer, MG. Diaz, Y. Gonzalez-Lama, O. Goulet, G. Guariso, N. Gurcan, M. Homan, JP. Hugot, E. Jeziorski, E. Karanika, A. Lachaux, P. Lewindon, R. Lima, F. Magro, J. Major, G. Malamut, E. Mas, I. Mattyus, LM. Mearin, J. Melek, VM. Navas-Lopez, A. Paerregaard, C. Pelatan, B. Pigneur, IP. Pais, J. Rebeuh, C. Romano, N. Siala, C. Strisciuglio, M. Tempia-Caliera, P. Tounian, D. Turner, V. Urbonas, S. Willot, FM. Ruemmele, N. Cerf-Bensussan,
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- $a BACKGROUND AND AIMS: An expanding number of monogenic defects have been identified as causative of severe forms of very early-onset inflammatory bowel diseases [VEO-IBD]. The present study aimed at defining how next-generation sequencing [NGS] methods can be used to improve identification of known molecular diagnosis and to adapt treatment. METHODS: A total of 207 children were recruited in 45 paediatric centres through an international collaborative network [ESPGHAN GENIUS working group] with a clinical presentation of severe VEO-IBD [n = 185] or an anamnesis suggestive of a monogenic disorder [n = 22]. Patients were divided at inclusion into three phenotypic subsets: predominantly small bowel inflammation, colitis with perianal lesions, and colitis only. Methods to obtain molecular diagnosis included functional tests followed by specific Sanger sequencing, custom-made targeted NGS, and in selected cases whole exome sequencing [WES] of parents-child trios. Genetic findings were validated clinically and/or functionally. RESULTS: Molecular diagnosis was achieved in 66/207 children [32%]: 61% with small bowel inflammation, 39% with colitis and perianal lesions, and 18% with colitis only. Targeted NGS pinpointed gene mutations causative of atypical presentations, and identified large exonic copy number variations previously missed by WES. CONCLUSIONS: Our results lead us to propose an optimised diagnostic strategy to identify known monogenic causes of severe IBD.
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- 700 1_
- $a Parlato, Marianna $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN].
- 700 1_
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- 700 1_
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- 700 1_
- $a Nowak, Jan $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Begue, Bernadette $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN].
- 700 1_
- $a Rakotobe, Sabine $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN].
- 700 1_
- $a Bruneau, Julie $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Pathology Department, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 700 1_
- $a Fourrage, Cécile $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Bioinformatics Platform, Imagine Institute Paris, France.
- 700 1_
- $a Alibeu, Olivier $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Genomic Platform, Imagine Institute, Paris, France.
- 700 1_
- $a Rieux-Laucat, Frédéric $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. INSERM, UMR1163, Immunogenetics of Paediatric Autoimmunity, and Imagine Institute, Paris, France.
- 700 1_
- $a Lévy, Eva $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. INSERM, UMR1163, Immunogenetics of Paediatric Autoimmunity, and Imagine Institute, Paris, France.
- 700 1_
- $a Stolzenberg, Marie-Claude $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. INSERM, UMR1163, Immunogenetics of Paediatric Autoimmunity, and Imagine Institute, Paris, France.
- 700 1_
- $a Mazerolles, Fabienne $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. INSERM, UMR1163, Immunogenetics of Paediatric Autoimmunity, and Imagine Institute, Paris, France.
- 700 1_
- $a Latour, Sylvain $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. INSERM, UMR1163, Lymphocyte activation and EBV susceptibility, and Imagine Institute, Paris France.
- 700 1_
- $a Lenoir, Christelle $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. INSERM, UMR1163, Lymphocyte activation and EBV susceptibility, and Imagine Institute, Paris France.
- 700 1_
- $a Fischer, Alain $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Collège de France, Médecine expérimentale, Paris, France. INSERM UMR 1163 and Imagine Institute, Paris, France.
- 700 1_
- $a Picard, Capucine $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. INSERM, UMR1163, Lymphocyte activation and EBV susceptibility, and Imagine Institute, Paris France. Investigation Centre for Immunodeficiency, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris and Imagine Institute, Paris, France.
- 700 1_
- $a Aloi, Marina $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Sapienza University of Rome, Paediatric Gastroenterology and Liver Unit, Department of Pediatrics, Rome, Italy.
- 700 1_
- $a Dias, Jorge Amil $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Centro Hospitalar São João, Porto, Portugal.
- 700 1_
- $a Hariz, Mongi Ben $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Hopital La Marsa, Tunisia.
- 700 1_
- $a Bourrier, Anne $u Department of Gastroenterology, Hôpital St Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 700 1_
- $a Breuer, Christian $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Universitätsklinikum Hamburg, Hamburg, Germany.
- 700 1_
- $a Breton, Anne $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Gastroenterology, Hepatology, Nutrition, and Diabetes, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
- 700 1_
- $a Bronski, Jiri $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. University Hospital Motol, Prague, Czech Republic.
- 700 1_
- $a Buderus, Stephan $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. St. Marien Hospital, Bonn, Germany.
- 700 1_
- $a Cananzi, Mara $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Unit of Paediatric Hepatology, Department of Woman and Child Health, University Hospital of Padova, Padova, Italy.
- 700 1_
- $a Coopman, Stéphanie $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Jeanne De Flandre Children's Hospital, Lille University Faculty of Medicine, Lille, France.
- 700 1_
- $a Crémilleux, Clara $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Centre Hospitalo-Universitaire de St-Etienne, St-Etienne, France.
- 700 1_
- $a Dabadie, Alain $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Service de médecine de l'enfant et de l'adolescent, Hôpital Sud - Centre Hospitalo-Universitaire de Rennes, Rennes, France.
- 700 1_
- $a Dumant-Forest, Clémentine $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Centre Hospitalo-Universitaire Charles Nicolle, Rouen, France.
- 700 1_
- $a Gurkan, Odul Egritas $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Paediatric Gastroenterology, Hepatology and Nutrition, Gazi University, Ankara, Turkey.
- 700 1_
- $a Fabre, Alexandre $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Assistance publique Hôpitaux de Marseille, Hôpital de la Timone, Marseille, France.
- 700 1_
- $a Fischer, Aude $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Centre Hospitalo-Universitaire Sud Réunion, St Pierre, France.
- 700 1_
- $a Diaz, Marta German $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Unit of Paediatric Nutrition, Hospital Universitario 12 de Octubre, Madrid, Spain.
- 700 1_
- $a Gonzalez-Lama, Yago $u Inflammatory Bowel Disease Unit, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
- 700 1_
- $a Goulet, Olivier $u Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Paediatric Gastroenterology, Hepatology and Nutrition Unit, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN].
- 700 1_
- $a Guariso, Graziella $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. University of Padua, Italy.
- 700 1_
- $a Gurcan, Neslihan $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Paediatric Gastroenterology, Hepatology and Nutrition, Gazi University, Ankara, Turkey.
- 700 1_
- $a Homan, Matjaz $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Ljubljana, Slovenia.
- 700 1_
- $a Hugot, Jean-Pierre $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Departments of Paediatric Digestive and Respiratory Diseases, Hôpital Robert-Debré, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 700 1_
- $a Jeziorski, Eric $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Infectious diseases and Immunology, Centre Hospitalo-Universitaire de Montpellier, Montpellier, France.
- 700 1_
- $a Karanika, Evi $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, University General Hospital of Thessaloniki, Thessaloniki, Greece.
- 700 1_
- $a Lachaux, Alain $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatric Gastroenterology, Hepatology and Nutrition, Centre de Nutrition parentérale à domicile, Hôpital Femme-Mère-Enfant CHU de Lyon HCL - GH Est, Bron, France.
- 700 1_
- $a Lewindon, Peter $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Gastroenterology and Hepatology, Lady Cilento Children's Hospital and the Faculty of Medicine and Biomedical Sciences, TUniversity of Queensland, Brisbane, Australia.
- 700 1_
- $a Lima, Rosa $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Centro Hospitalar São João, Porto, Portugal.
- 700 1_
- $a Magro, Fernando $u Gastroenterology Department, Hospital de São João, Institute of Pharmacology and Therapeutics Faculty of Medicine and MedInUP - Centre for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.
- 700 1_
- $a Major, Janos $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. MRE Bethesda Gyermekkórháza; Department of Pediatrics, Budapest, Hungary.
- 700 1_
- $a Malamut, Georgia $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Department of Gastroenterology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 700 1_
- $a Mas, Emmanuel $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Gastroenterology, Hepatology, Nutrition, and Diabetes, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
- 700 1_
- $a Mattyus, Istvan $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Semmelweis University; Department of Paediatrics, Budapest, Hungary.
- 700 1_
- $a Mearin, Luisa M $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Leiden University Medical Centre, Department of Paediatrics, Leiden, The Netherlands.
- 700 1_
- $a Melek, Jan $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. University Hospital, Hradec Kralove, Czech Republic.
- 700 1_
- $a Navas-Lopez, Victor Manuel $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Hospital Regional Universitario de Málaga, Departamento de Pediatría, Malaga, Spain.
- 700 1_
- $a Paerregaard, Anders $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Hvidovre University Hospital, Department of Paediatrics, Copenhagen, Denmark.
- 700 1_
- $a Pelatan, Cecile $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Centre Hospitalier du Mans, Le Mans, France.
- 700 1_
- $a Pigneur, Bénédicte $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Paediatric Gastroenterology, Hepatology and Nutrition Unit, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN].
- 700 1_
- $a Pais, Isabel Pinto $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Centro Hospitalar Gaia Espinho, Department of Paediatrics, Vila Nova de Gaia, Portugal.
- 700 1_
- $a Rebeuh, Julie $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Centre Hospitalo-Universitaire de Strasbourg, Strasbourg, France.
- 700 1_
- $a Romano, Claudio $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Hospital of Messina, University of Messina, Messina, Italy.
- 700 1_
- $a Siala, Nadia $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Hôpital Mongi Slim, La Marsa, Tunisia.
- 700 1_
- $a Strisciuglio, Caterina $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Woman, Child and General and Specialized Surgery, Second University of Naples, Naples, Italy.
- 700 1_
- $a Tempia-Caliera, Michela $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, FMH Pédiatrie et FA Gastroentérologie et hépatologie, Clinique des Grangettes, Geneva, Switzerland.
- 700 1_
- $a Tounian, Patrick $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatric Nutrition and Gastroenterology, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.
- 700 1_
- $a Turner, Dan $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Shaare Zedek Medical Centre, Jerusalem, Israel.
- 700 1_
- $a Urbonas, Vaidotas $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatric Gastroenterology, Vilnius University Clinic for Children's Diseases, Vilnius, Lithuania.
- 700 1_
- $a Willot, Stéphanie $u GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN]. Department of Paediatrics, Centre hospitalier régional universitaire, Hôpital Clocheville, Tours, France.
- 700 1_
- $a Ruemmele, Frank M $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Paediatric Gastroenterology, Hepatology and Nutrition Unit, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN].
- 700 1_
- $a Cerf-Bensussan, Nadine $u INSERM, UMR1163, Laboratory of Intestinal Immunity, and Imagine Institute, Paris, France. Université Paris Descartes-Sorbonne Paris Cité, Paris, France. GENIUS Group [GENetically ImmUne-mediated enteropathieS] from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition [ESPGHAN].
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- $a 2018 $b 12 $c 9 $d 1104-1112 $e 2018Aug29 $i 1876-4479 $m Journal of Crohn's and colitis $n J Crohns Colitis $x MED00166945
- GRA __
- $a 339407 $p European Research Council $2 International
- LZP __
- $a Pubmed-20201125
