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Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair
B. East, M. Plencner, M. Otahal, E. Amler, AC. de Beaux,
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NV17-32285A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
NLK
ProQuest Central
od 1999-06-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2003-03-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1999-06-01 do Před 1 rokem
- MeSH
- abdominální hernie * etiologie chirurgie MeSH
- abdominoplastika přístrojové vybavení metody MeSH
- chirurgické síťky * MeSH
- incizní kýla * etiologie chirurgie MeSH
- králíci MeSH
- modely nemocí na zvířatech MeSH
- nanovlákna terapeutické užití MeSH
- operace kýly přístrojové vybavení metody MeSH
- pevnost v tahu MeSH
- polypropyleny terapeutické užití MeSH
- pružnost MeSH
- testování materiálů MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
PURPOSE: Incisional hernia is the most common complication following abdominal surgery. While mesh repair is common, none of the current meshes mimic the physiology of the abdominal wall. This study compares suture only repair with polypropylene mesh and a prototype of a novel implant (poly-epsilon-caprolactone nanofibers) and their influence on the physiology of an abdominal wall in an animal model. METHODS: 27 Chinchilla rabbits were divided into six groups based on the type of the implant. Midline abdominal incision was repaired using one of the compared materials with suture alone serving as the control. 6 weeks post-surgery animals were killed and their explanted abdominal wall subjected to biomechanical testing. RESULTS: Both-hysteresis and maximum strength curves showed high elasticity and strength in groups where the novel implant was used. Polypropylene mesh proved as stiff and fragile compared to other groups. CONCLUSION: Poly-epsilon-caprolactone nanofiber scaffold is able to improve the dynamic properties of healing fascia with no loss of maximum tensile strength when compared to polypropylene mesh in an animal model.
Citace poskytuje Crossref.org
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- $a East, B $u 3rd Department of Surgery, Motol University Hospital, V uvalu 84, 15006, Prague, Czech Republic. Barbora.east@gmail.com. 2nd Medical Faculty at Charles University, V uvalu 84, 15006, Prague, Czech Republic. Barbora.east@gmail.com.
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- $a Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair / $c B. East, M. Plencner, M. Otahal, E. Amler, AC. de Beaux,
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- $a PURPOSE: Incisional hernia is the most common complication following abdominal surgery. While mesh repair is common, none of the current meshes mimic the physiology of the abdominal wall. This study compares suture only repair with polypropylene mesh and a prototype of a novel implant (poly-epsilon-caprolactone nanofibers) and their influence on the physiology of an abdominal wall in an animal model. METHODS: 27 Chinchilla rabbits were divided into six groups based on the type of the implant. Midline abdominal incision was repaired using one of the compared materials with suture alone serving as the control. 6 weeks post-surgery animals were killed and their explanted abdominal wall subjected to biomechanical testing. RESULTS: Both-hysteresis and maximum strength curves showed high elasticity and strength in groups where the novel implant was used. Polypropylene mesh proved as stiff and fragile compared to other groups. CONCLUSION: Poly-epsilon-caprolactone nanofiber scaffold is able to improve the dynamic properties of healing fascia with no loss of maximum tensile strength when compared to polypropylene mesh in an animal model.
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- $a Plencner, M $u Department of Biophysics, 2nd Medical Faculty, Charles University, V uvalu 84, 15006, Prague, Czech Republic. Laboratory of Tissue Engineering, Department of Experimental Medicine, Czech Academy of Science, Videnska 1083, 142 20, Prague, Czech Republic.
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- $a Otahal, M $u Department of Biomechanics and Anatomy, Faculty of Physical Education and Sport, Charles University, José Martího 31, 162 52, Prague, Czech Republic. Department of Natural Sciences, Faculty of Biomedical Engineering, Czech Technical University in Prague, Jugoslávských partyzánů 1580/3, 160 00, Prague, Czech Republic.
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- $a de Beaux, A C $u Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh, EH16 4SA, UK.
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