• Je něco špatně v tomto záznamu ?

Architecture and Evolution of Blade Assembly in β-propeller Lectins

F. Bonnardel, A. Kumar, M. Wimmerova, M. Lahmann, S. Perez, A. Varrot, F. Lisacek, A. Imberty,

. 2019 ; 27 (5) : 764-775.e3. [pub] 20190307

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20023950
E-zdroje Online Plný text

NLK Cell Press Free Archives od 1995-01-01 do Před 1 rokem
Free Medical Journals od 1995 do Před 1 rokem
Free Medical Journals od 1995 do Před 1 rokem
Elsevier Open Access Journals od 1995-01-01 do Před 1 rokem
Elsevier Open Archive Journals od 1995-01-01 do Před 1 rokem

Odkazy

PubMed 30853410
DOI 10.1016/j.str.2019.02.002
Knihovny.cz E-zdroje

Lectins with a β-propeller fold bind glycans on the cell surface through multivalent binding sites and appropriate directionality. These proteins are formed by repeats of short domains, raising questions about evolutionary duplication. However, these repeats are difficult to detect in translated genomes and seldom correctly annotated in sequence databases. To address these issues, we defined the blade signature of the five types of β-propellers using 3D-structural data. With these templates, we predicted 3,887 β-propeller lectins in 1,889 species and organized this information in a searchable online database. The data reveal a widespread distribution of β-propeller lectins across species. Prediction also emphasizes multiple architectures and led to the discovery of a β-propeller assembly scenario. This was confirmed by producing and characterizing a predicted protein coded in the genome of Kordia zhangzhouensis. The crystal structure uncovers an intermediate in the evolution of β-propeller assembly and demonstrates the power of our tools.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20023950
003      
CZ-PrNML
005      
20201214131856.0
007      
ta
008      
201125s2019 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.str.2019.02.002 $2 doi
035    __
$a (PubMed)30853410
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Bonnardel, François $u University of Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France; Swiss Institute of Bioinformatics, 1227 Geneva, Switzerland; Computer Science Department, UniGe, 1227 Geneva, Switzerland.
245    10
$a Architecture and Evolution of Blade Assembly in β-propeller Lectins / $c F. Bonnardel, A. Kumar, M. Wimmerova, M. Lahmann, S. Perez, A. Varrot, F. Lisacek, A. Imberty,
520    9_
$a Lectins with a β-propeller fold bind glycans on the cell surface through multivalent binding sites and appropriate directionality. These proteins are formed by repeats of short domains, raising questions about evolutionary duplication. However, these repeats are difficult to detect in translated genomes and seldom correctly annotated in sequence databases. To address these issues, we defined the blade signature of the five types of β-propellers using 3D-structural data. With these templates, we predicted 3,887 β-propeller lectins in 1,889 species and organized this information in a searchable online database. The data reveal a widespread distribution of β-propeller lectins across species. Prediction also emphasizes multiple architectures and led to the discovery of a β-propeller assembly scenario. This was confirmed by producing and characterizing a predicted protein coded in the genome of Kordia zhangzhouensis. The crystal structure uncovers an intermediate in the evolution of β-propeller assembly and demonstrates the power of our tools.
650    _2
$a sekvence aminokyselin $7 D000595
650    _2
$a Archaea $x chemie $7 D001105
650    _2
$a Bacteria $x chemie $7 D001419
650    _2
$a vazebná místa $7 D001665
650    _2
$a databáze proteinů $7 D030562
650    _2
$a Eukaryota $x chemie $7 D056890
650    _2
$a genom bakteriální $7 D016680
650    _2
$a lektiny $x chemie $7 D037102
650    _2
$a molekulární modely $7 D008958
650    _2
$a sbalování proteinů $7 D017510
650    _2
$a multimerizace proteinu $7 D055503
650    _2
$a sekundární struktura proteinů $7 D017433
650    _2
$a proteom $7 D020543
650    _2
$a sekvenční seřazení $7 D016415
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kumar, Atul $u University of Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France; CEITEC, Masaryk University, 625 00 Brno, Czech Republic.
700    1_
$a Wimmerova, Michaela $u CEITEC, Masaryk University, 625 00 Brno, Czech Republic; NCBR, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
700    1_
$a Lahmann, Martina $u School of Chemistry, University of Bangor, LL57 2UW Bangor, UK.
700    1_
$a Perez, Serge $u University of Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France.
700    1_
$a Varrot, Annabelle $u University of Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France.
700    1_
$a Lisacek, Frédérique $u Swiss Institute of Bioinformatics, 1227 Geneva, Switzerland; Computer Science Department, UniGe, 1227 Geneva, Switzerland; Section of Biology, UniGe, 1205 Geneva, Switzerland. Electronic address: frederique.lisacek@sib.swiss.
700    1_
$a Imberty, Anne $u University of Grenoble Alpes, CNRS, CERMAV, 38000 Grenoble, France. Electronic address: anne.imberty@cermav.cnrs.fr.
773    0_
$w MED00006440 $t Structure (London, England : 1993) $x 1878-4186 $g Roč. 27, č. 5 (2019), s. 764-775.e3
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30853410 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201214131856 $b ABA008
999    __
$a ok $b bmc $g 1596269 $s 1114626
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 27 $c 5 $d 764-775.e3 $e 20190307 $i 1878-4186 $m Structure $n Structure $x MED00006440
LZP    __
$a Pubmed-20201125

Najít záznam

Citační ukazatele

Možnosti archivace