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Critical slowing down as a biomarker for seizure susceptibility
MI. Maturana, C. Meisel, K. Dell, PJ. Karoly, W. D'Souza, DB. Grayden, AN. Burkitt, P. Jiruska, J. Kudlacek, J. Hlinka, MJ. Cook, L. Kuhlmann, DR. Freestone,
Jazyk angličtina Země Velká Británie
Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem
Grantová podpora
NV17-28427A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
NLK
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- MeSH
- algoritmy MeSH
- biologické markery MeSH
- elektrokortikografie MeSH
- epilepsie parciální diagnóza MeSH
- lidé MeSH
- modely neurologické MeSH
- mozek patofyziologie MeSH
- rizikové faktory MeSH
- záchvaty diagnóza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit critical slowing down, a warning signal preceding many critical transitions in dynamical systems. Using long-term intracranial electroencephalography (iEEG) recordings from fourteen patients with focal epilepsy, we monitored key signatures of critical slowing down prior to seizures. The metrics used to detect critical slowing down fluctuated over temporally long scales (hours to days), longer than would be detectable in standard clinical evaluation settings. Seizure risk was associated with a combination of these signals together with epileptiform discharges. These results provide strong validation of theoretical models and demonstrate that critical slowing down is a reliable indicator that could be used in seizure forecasting algorithms.
Department of Biomedical Engineering The University of Melbourne Melbourne Australia
Department of Medicine St Vincent's Hospital The University of Melbourne Melbourne Australia
Graeme Clark Institute The University of Melbourne Melbourne Australia
Citace poskytuje Crossref.org
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- $a Maturana, Matias I $u Department of Medicine, St Vincent's Hospital, The University of Melbourne, Melbourne, Australia. matiasim@unimelb.edu.au. Seer Medical, Melbourne, Australia. matiasim@unimelb.edu.au.
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- $a Kudlacek, Jan $u Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic. Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
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