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The high-resolution proteomic analysis of protein composition of rat spleen lymphocytes stimulated by Concanavalin A; a comparison with morphine-treated cells
H. Ujcikova, K. Cechova, L. Roubalova, J. Brejchova, J. Kaufman, V. Holan, P. Svoboda,
Journal of neuroimmunology.
2020 ;
341 (-) :
577191.
[pub] 20200213
Jazyk angličtina Země Nizozemsko
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc20025083
- MeSH
- aktivace lymfocytů účinky léků genetika MeSH
- konkanavalin A farmakologie MeSH
- krysa rodu rattus MeSH
- lymfocyty účinky léků metabolismus MeSH
- morfin farmakologie MeSH
- potkani Wistar MeSH
- proteom účinky léků MeSH
- proteomika metody MeSH
- regulace genové exprese účinky léků MeSH
- slezina cytologie MeSH
- stanovení celkové genové exprese MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
Morphine- and Concanavalin A-induced changes of protein composition of rat spleen lymphocytes were determined by high-resolution proteomic analysis, gel-free, label-free quantification, MaxLFQ. Stimulation by Con A resulted in a major reorganization of spleen cell protein composition evidenced by increased expression level of 94 proteins; 101 proteins were down-regulated (>2-fold). Interestingly, among proteins that were up-regulated to the largest extent were the prototypical brain proteins as a neuron specific enolase, synapsin-1, brain acid-soluble protein-1 and myelin basic protein. Morphine-induced change was limited to no more than 5 up-regulated and 18 down-regulated proteins (>2-fold).
Citace poskytuje Crossref.org
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- $a Morphine- and Concanavalin A-induced changes of protein composition of rat spleen lymphocytes were determined by high-resolution proteomic analysis, gel-free, label-free quantification, MaxLFQ. Stimulation by Con A resulted in a major reorganization of spleen cell protein composition evidenced by increased expression level of 94 proteins; 101 proteins were down-regulated (>2-fold). Interestingly, among proteins that were up-regulated to the largest extent were the prototypical brain proteins as a neuron specific enolase, synapsin-1, brain acid-soluble protein-1 and myelin basic protein. Morphine-induced change was limited to no more than 5 up-regulated and 18 down-regulated proteins (>2-fold).
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