Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Insight into the epigenetic landscape of a currently endogenizing gammaretrovirus in mule deer (Odocoileus hemionus)

T. Hron, H. Fabryova, D. Elleder,

. 2020 ; 112 (1) : 886-896. [pub] 20190605

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20025309

Endogenous retroviruses (ERVs) constitute a significant part of vertebrate genomes. They originated from past retroviral infections and some of them retain transcriptional activity. The key mechanism avoiding uncontrolled ERV transcription is DNA methylation-mediated epigenetic silencing. Despite numerous studies describing the involvement of ERV activity in cellular processes, epigenetic regulation of ERVs is still poorly understood. We previously described a cervid endogenous retrovirus (CrERV) in the mule deer genome. This virus exhibits massive insertional polymorphism, suggesting recent activity. Here we employed NGS-based strategy to determine the methylation pattern of CrERV integrations in four mule deer. Besides the vast majority of methylated integrations, we identified a tiny fraction of demethylated proviral copies. These copies represent evolutionary older integrations located near gene promoters. In general, our work is a first attempt to characterize the epigenetic landscape of insertionally polymorphic ERV on a whole-genome scale and offers insight into its interactions with a host.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20025309
003      
CZ-PrNML
005      
20201222155145.0
007      
ta
008      
201125s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ygeno.2019.06.003 $2 doi
035    __
$a (PubMed)31175981
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Hron, Tomas $u Institute of Molecular Genetics, The Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic; Faculty of Science, Charles University, Albertov 6, 128 43 Praha 2, Czech Republic. Electronic address: tomas.hron@img.cas.cz.
245    10
$a Insight into the epigenetic landscape of a currently endogenizing gammaretrovirus in mule deer (Odocoileus hemionus) / $c T. Hron, H. Fabryova, D. Elleder,
520    9_
$a Endogenous retroviruses (ERVs) constitute a significant part of vertebrate genomes. They originated from past retroviral infections and some of them retain transcriptional activity. The key mechanism avoiding uncontrolled ERV transcription is DNA methylation-mediated epigenetic silencing. Despite numerous studies describing the involvement of ERV activity in cellular processes, epigenetic regulation of ERVs is still poorly understood. We previously described a cervid endogenous retrovirus (CrERV) in the mule deer genome. This virus exhibits massive insertional polymorphism, suggesting recent activity. Here we employed NGS-based strategy to determine the methylation pattern of CrERV integrations in four mule deer. Besides the vast majority of methylated integrations, we identified a tiny fraction of demethylated proviral copies. These copies represent evolutionary older integrations located near gene promoters. In general, our work is a first attempt to characterize the epigenetic landscape of insertionally polymorphic ERV on a whole-genome scale and offers insight into its interactions with a host.
650    _2
$a zvířata $7 D000818
650    _2
$a metylace DNA $7 D019175
650    _2
$a vysoká zvěř $x genetika $7 D003670
650    12
$a endogenní retroviry $7 D020077
650    12
$a epigeneze genetická $7 D044127
650    _2
$a Gammaretrovirus $x genetika $7 D017988
650    _2
$a koncové repetice $7 D020079
650    _2
$a integrace viru $7 D016662
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Fabryova, Helena $u Institute of Molecular Genetics, The Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic; Faculty of Science, Charles University, Albertov 6, 128 43 Praha 2, Czech Republic.
700    1_
$a Elleder, Daniel $u Institute of Molecular Genetics, The Czech Academy of Sciences, Videnska 1083, Prague, 14220, Czech Republic. Electronic address: daniel.elleder@img.cas.cz.
773    0_
$w MED00001912 $t Genomics $x 1089-8646 $g Roč. 112, č. 1 (2020), s. 886-896
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31175981 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201222155141 $b ABA008
999    __
$a ok $b bmc $g 1599454 $s 1115995
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 112 $c 1 $d 886-896 $e 20190605 $i 1089-8646 $m Genomics (San Diego, Calif.) $n Genomic $x MED00001912
LZP    __
$a Pubmed-20201125

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace