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Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)-block-poly(oxirane)-based nanofibrous electrospun polyester-ether-urethanes used as potential drug-delivery system
A. Pavelková, P. Kucharczyk, Z. Capáková, P. Peer, M. Pummerová, J. Zedník, J. Vohlídal, V. Sedlařík,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
15-08287Y
Grantová Agentura České Republiky - International
67985874.
RVO - International
CEP Register
67985874
RVO - International
CEP Register
15-08287Y
Czech Science Foundation - International
CZ.1.05/2.1.00/19.0409
Ministry of Education, Youth and Sports of the Czech Republic within the NPU I programme - International
LO1504
Ministry of Education, Youth and Sports of the Czech Republic within the NPU I programme - International
PubMed
30690889
DOI
10.1002/jbm.b.34331
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents * chemistry pharmacology MeSH
- NIH 3T3 Cells MeSH
- Drug Delivery Systems * MeSH
- Mice MeSH
- Nanofibers chemistry MeSH
- Polyesters chemistry pharmacology MeSH
- Polyethylene Glycols chemistry pharmacology MeSH
- Polyurethanes chemistry pharmacology MeSH
- Materials Testing * MeSH
- Vancomycin * chemistry pharmacology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Poly(lactic acid)-block-poly(oxirane)s (PLA-b-POE) of various compositions were prepared using a one-pot approach and then extended in a reaction with l-lysine diethyl ester diisocyanate, thereby forming polyester-ether-urethanes (PEU) with prolonged chains and units with increased degradability. The PEUs are processed by electrospinning to prepare degradable nanofibrous sheet materials with and without encapsulating the antibiotic Vancomycin (VAC). PLA block isomerism and POE blocks oligomeric content (1000 g/mol) affect the thermal properties, processability, nanofibrous sheet morphology, abiotic degradation, cytocompatibility, and encapsulated antibiotic release rate of prepared PEUs. Therefore, our findings provide an effective approach to tuning the functional properties of these advanced biocompatible materials. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2378-2387, 2019.
References provided by Crossref.org
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