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Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)-block-poly(oxirane)-based nanofibrous electrospun polyester-ether-urethanes used as potential drug-delivery system

A. Pavelková, P. Kucharczyk, Z. Capáková, P. Peer, M. Pummerová, J. Zedník, J. Vohlídal, V. Sedlařík,

. 2019 ; 107 (7) : 2378-2387. [pub] 20190128

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20025613

Grantová podpora
15-08287Y Grantová Agentura České Republiky - International
67985874. RVO - International CEP - Centrální evidence projektů
67985874 RVO - International CEP - Centrální evidence projektů
15-08287Y Czech Science Foundation - International
CZ.1.05/2.1.00/19.0409 Ministry of Education, Youth and Sports of the Czech Republic within the NPU I programme - International
LO1504 Ministry of Education, Youth and Sports of the Czech Republic within the NPU I programme - International

Poly(lactic acid)-block-poly(oxirane)s (PLA-b-POE) of various compositions were prepared using a one-pot approach and then extended in a reaction with l-lysine diethyl ester diisocyanate, thereby forming polyester-ether-urethanes (PEU) with prolonged chains and units with increased degradability. The PEUs are processed by electrospinning to prepare degradable nanofibrous sheet materials with and without encapsulating the antibiotic Vancomycin (VAC). PLA block isomerism and POE blocks oligomeric content (1000 g/mol) affect the thermal properties, processability, nanofibrous sheet morphology, abiotic degradation, cytocompatibility, and encapsulated antibiotic release rate of prepared PEUs. Therefore, our findings provide an effective approach to tuning the functional properties of these advanced biocompatible materials. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2378-2387, 2019.

Citace poskytuje Crossref.org

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