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Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models

G. Caluori, A. Wojtaszczyk, O. Yasin, M. Pesl, J. Wolf, S. Belaskova, M. Crha, A. Sugrue, VR. Vaidya, N. Naksuk, CV. DeSimone, AM. Killu, D. Padmanabhan, SJ. Asirvatham, Z. Stárek,

. 2019 ; 42 (7) : 862-867. [pub] 20190429

Language English Country United States

Document type Comparative Study, Journal Article

Persistent link   https://www.medvik.cz/link/bmc20025811

BACKGROUND: Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters. METHODS: We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded. RESULTS: Ventricular arrhythmias requiring cardioversion occurred in 13.11% of radiofrequency ablation applications in swine and 9.75% in canine (relative risk: 117.6%, 95% confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]: .55, 95% CI: .23-61.33; P = .184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95% CI: 1.35-9.55; P = .010). CONCLUSIONS: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.

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$a BACKGROUND: Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters. METHODS: We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded. RESULTS: Ventricular arrhythmias requiring cardioversion occurred in 13.11% of radiofrequency ablation applications in swine and 9.75% in canine (relative risk: 117.6%, 95% confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]: .55, 95% CI: .23-61.33; P = .184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95% CI: 1.35-9.55; P = .010). CONCLUSIONS: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.
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$a Wojtaszczyk, Adam $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
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$a Yasin, Omar $u Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
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$a Pesl, Martin $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. First Department of Internal Medicine/Cardioangiology, St. Anne´s Hospital, Masaryk University, Brno, Czech Republic. Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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$a Wolf, Jiří $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
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$a Belaskova, Silvie $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
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$a Crha, Michal $u University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
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$a Sugrue, Alan $u Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
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$a Vaidya, Vaibhav R $u Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
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$a Naksuk, Niyada $u Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
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$a DeSimone, Christopher V $u Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
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$a Killu, Ammar M $u Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
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$a Padmanabhan, Deepak $u Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
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$a Asirvatham, Samuel J $u Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota. Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
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$a Stárek, Zdeněk $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. First Department of Internal Medicine/Cardioangiology, St. Anne´s Hospital, Masaryk University, Brno, Czech Republic.
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