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Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity
S. Salajkova, M. Sramek, D. Malinak, F. Havel, K. Musilek, M. Benkova, O. Soukup, P. Vasicova, L. Prchal, R. Dolezal, Z. Hodny, J. Bartek, M. Zarska, K. Kuca,
Jazyk angličtina Země Německo
Typ dokumentu dopisy, práce podpořená grantem
Grantová podpora
GA16-13967S
Grant Agency of the Czech Republic - International
RVO 68378050
Institutional Grant - International
Project NV15-31847A - International
Long Term Development plan - 1011 - International
00179906
MH CZ - DRO - International
VT2019-2021
University of Hradec Kralove - International
PubMed
31298802
DOI
10.1002/jbio.201900024
Knihovny.cz E-zdroje
- MeSH
- alkylace MeSH
- CHO buňky MeSH
- Cricetulus MeSH
- hydrofobní a hydrofilní interakce * MeSH
- kvartérní amoniové sloučeniny chemie MeSH
- nanotrubičky chemie MeSH
- povrchově aktivní látky chemie MeSH
- stabilita léku MeSH
- viabilita buněk účinky léků MeSH
- zlato chemie toxicita MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- dopisy MeSH
- práce podpořená grantem MeSH
The photothermal cancer therapy using cationic gold nanorods (GNRs) stabilized by quaternary ammonium salts (QAS) have a great potential to enhance conventional cancer treatment as it promises the effective eradication of cancer cells including cells resistant to radio- and chemo-therapy and the stimulation of anti-tumor immune response. However, as the cytotoxicity of the conventional alkanethiol-QAS compounds limits their utility in medicine, here we developed GNRs modified by novel highly hydrophilic cationic surfactant composed of the quaternary ammonium group and ethylene glycol chain N,N,N-trimethyl-3,6,9,12,15-pentaoxaheptadecyl-17-sulfanyl-1-ammonium bromide (POSAB) showing insignificant cytotoxicity in the free state. Surface modification of GNRs by POSAB allowed to prepare nanoparticles with good stability in water, high cellular uptake and localization in lysosomes that are a promising alternative to alkanethiol-stabilized GNRs especially for biomedical applications.
Citace poskytuje Crossref.org
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- $a Salajkova, Sarka $u Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
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- $a Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity / $c S. Salajkova, M. Sramek, D. Malinak, F. Havel, K. Musilek, M. Benkova, O. Soukup, P. Vasicova, L. Prchal, R. Dolezal, Z. Hodny, J. Bartek, M. Zarska, K. Kuca,
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- $a The photothermal cancer therapy using cationic gold nanorods (GNRs) stabilized by quaternary ammonium salts (QAS) have a great potential to enhance conventional cancer treatment as it promises the effective eradication of cancer cells including cells resistant to radio- and chemo-therapy and the stimulation of anti-tumor immune response. However, as the cytotoxicity of the conventional alkanethiol-QAS compounds limits their utility in medicine, here we developed GNRs modified by novel highly hydrophilic cationic surfactant composed of the quaternary ammonium group and ethylene glycol chain N,N,N-trimethyl-3,6,9,12,15-pentaoxaheptadecyl-17-sulfanyl-1-ammonium bromide (POSAB) showing insignificant cytotoxicity in the free state. Surface modification of GNRs by POSAB allowed to prepare nanoparticles with good stability in water, high cellular uptake and localization in lysosomes that are a promising alternative to alkanethiol-stabilized GNRs especially for biomedical applications.
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- $a Havel, Filip $u Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. Department of Physical Electronics, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
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- $a Musilek, Kamil $u Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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- $a Dolezal, Rafael $u Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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- $a Hodny, Zdenek $u Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
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- $a Bártek, Jiří, $d 1953- $u Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark. Department of Medical Biochemistry and Biophysics, Science For Life Laboratory, Division of Genome Biology, Karolinska Institute, Solna, Sweden. $7 xx0046271
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- $a Zarska, Monika $u Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. Charles University, First Faculty of Medicine, Prague, Czech Republic.
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- $a Kuca, Kamil $u Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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