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Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging

F. Albrecht, K. Mueller, T. Ballarini, L. Lampe, J. Diehl-Schmid, K. Fassbender, K. Fliessbach, H. Jahn, R. Jech, J. Kassubek, J. Kornhuber, B. Landwehrmeyer, M. Lauer, AC. Ludolph, E. Lyros, J. Prudlo, A. Schneider, M. Synofzik, J. Wiltfang, A....

. 2019 ; 117 (-) : 33-40. [pub] 20190225

Jazyk angličtina Země Itálie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20028855

Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia. The structure-function relationship of alien/anarchic limb was investigated in multi-centric structural magnetic resonance imaging (MRI) data. Whole-group and single-subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns. Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions. We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture.

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$a Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia. The structure-function relationship of alien/anarchic limb was investigated in multi-centric structural magnetic resonance imaging (MRI) data. Whole-group and single-subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns. Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions. We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture.
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$a Lampe, Leonie $u Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Clinic of Cognitive Neurology, University of Leipzig, Germany.
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$a Diehl-Schmid, Janine $u FTLD Consortium Germany, Germany; Department of Psychiatry and Psychotherapy, Technical University of Munich, Germany.
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$a Fassbender, Klaus $u FTLD Consortium Germany, Germany; Clinic for Neurology, Saarland University, Germany.
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$a Fliessbach, Klaus $u FTLD Consortium Germany, Germany; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Bonn, Germany.
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$a Jahn, Holger $u FTLD Consortium Germany, Germany; Clinic for Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Germany.
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$a Jech, Robert $u Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University, Prague, Czech Republic.
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$a Kassubek, Jan $u FTLD Consortium Germany, Germany; Clinic for Neurology, University of Ulm, Germany.
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$a Kornhuber, Johannes $u FTLD Consortium Germany, Germany; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.
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$a Landwehrmeyer, Bernhard $u Clinic for Neurology, University of Ulm, Germany.
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$a Lyros, Epameinondas $u FTLD Consortium Germany, Germany; Clinic for Neurology, Saarland University, Germany.
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$a Prudlo, Johannes $u FTLD Consortium Germany, Germany; Department of Neurology, Rostock University Medical Center, Rostock, Germany & German Center for Neurodegenerative Diseases, Rostock, Germany.
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$a Schneider, Anja $u FTLD Consortium Germany, Germany; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Bonn, Germany.
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$a Wiltfang, Jens $u FTLD Consortium Germany, Germany; University Medical Center Göttingen, Germany & German Center for Neurodegenerative Diseases (DZNE) Göttingen, Germany.
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$a Danek, Adrian $u FTLD Consortium Germany, Germany; Clinic of Neurology, Ludwig Maximilian University of Munich, Germany.
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$a Otto, Markus $u FTLD Consortium Germany, Germany; Clinic for Neurology, University of Ulm, Germany.
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