-
Something wrong with this record ?
Time delays in treatment of snakebite patients in rural Sri Lanka and the need for rapid diagnostic tests
A. Silva, J. Hlusicka, N. Siribaddana, S. Waiddyanatha, S. Pilapitiya, P. Weerawansa, N. Lokunarangoda, S. Thalgaspitiya, S. Siribaddana, GK. Isbister
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Directory of Open Access Journals
from 2007
Free Medical Journals
from 2007
Public Library of Science (PLoS)
from 2007
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2007-10-01
Open Access Digital Library
from 2007-08-30
Open Access Digital Library
from 2007-01-01
Open Access Digital Library
from 2007-01-01
Medline Complete (EBSCOhost)
from 2009-04-01
Health & Medicine (ProQuest)
from 2007-10-01
Public Health Database (ProQuest)
from 2007-10-01
ROAD: Directory of Open Access Scholarly Resources
from 2007
- MeSH
- Antivenins therapeutic use MeSH
- Time-to-Treatment statistics & numerical data MeSH
- Adult MeSH
- Snake Venoms * MeSH
- Snakes MeSH
- Hospitalization statistics & numerical data MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Prospective Studies MeSH
- First Aid MeSH
- Snake Bites diagnosis epidemiology therapy MeSH
- Rural Population MeSH
- Animals MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Sri Lanka MeSH
Delays in treatment seeking and antivenom administration remain problematic for snake envenoming. We aimed to describe the treatment seeking pattern and delays in admission to hospital and administration of antivenom in a cohort of authenticated snakebite patients. Adults (> 16 years), who presented with a confirmed snakebite from August 2013 to October 2014 were recruited from Anuradhapura Hospital. Demographic data, information on the circumstances of the bite, first aid, health-seeking behaviour, hospital admission, clinical features, outcomes and antivenom treatment were documented prospectively. There were 742 snakebite patients [median age: 40 years (IQR:27-51; males: 476 (64%)]. One hundred and five (14%) patients intentionally delayed treatment by a median of 45min (IQR:20-120min). Antivenom was administered a median of 230min (IQR:180-360min) post-bite, which didn't differ between directly admitted and transferred patients; 21 (8%) receiving antivenom within 2h and 141 (55%) within 4h of the bite. However, transferred patients received antivenom sooner after admission to Anuradhapura hospital than those directly admitted (60min [IQR:30-120min] versus 120min [IQR:52-265min; p<0.0001]). A significantly greater proportion of transferred patients had features of systemic envenoming on admission compared to those directly admitted (166/212 [78%] versus 5/43 [12%]; p<0.0001), and had positive clotting tests on admission (123/212 [58%] versus 10/43 [23%]; p<0.0001). Sri Lankan snakebite patients present early to hospital, but there remains a delay until antivenom administration. This delay reflects a delay in the appearance of observable or measurable features of envenoming and a lack of reliable early diagnostic tests. Improved early antivenom treatment will require reliable, rapid diagnostics for systemic envenoming.
Faculty of Medicine and Allied Sciences Rajarata University of Sri Lanka Saliyapura Sri Lanka
Monash Venom Group Faculty of Medicine Nursing and Health Sciences Monash University Australia
South Asian Clinical Toxicology Research Collaboration University of Peradeniya Peradeniya Sri Lanka
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21011827
- 003
- CZ-PrNML
- 005
- 20210507104200.0
- 007
- ta
- 008
- 210420s2020 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1371/journal.pntd.0008914 $2 doi
- 035 __
- $a (PubMed)33253208
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Silva, Anjana $u Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka $u Monash Venom Group, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia $u South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
- 245 10
- $a Time delays in treatment of snakebite patients in rural Sri Lanka and the need for rapid diagnostic tests / $c A. Silva, J. Hlusicka, N. Siribaddana, S. Waiddyanatha, S. Pilapitiya, P. Weerawansa, N. Lokunarangoda, S. Thalgaspitiya, S. Siribaddana, GK. Isbister
- 520 9_
- $a Delays in treatment seeking and antivenom administration remain problematic for snake envenoming. We aimed to describe the treatment seeking pattern and delays in admission to hospital and administration of antivenom in a cohort of authenticated snakebite patients. Adults (> 16 years), who presented with a confirmed snakebite from August 2013 to October 2014 were recruited from Anuradhapura Hospital. Demographic data, information on the circumstances of the bite, first aid, health-seeking behaviour, hospital admission, clinical features, outcomes and antivenom treatment were documented prospectively. There were 742 snakebite patients [median age: 40 years (IQR:27-51; males: 476 (64%)]. One hundred and five (14%) patients intentionally delayed treatment by a median of 45min (IQR:20-120min). Antivenom was administered a median of 230min (IQR:180-360min) post-bite, which didn't differ between directly admitted and transferred patients; 21 (8%) receiving antivenom within 2h and 141 (55%) within 4h of the bite. However, transferred patients received antivenom sooner after admission to Anuradhapura hospital than those directly admitted (60min [IQR:30-120min] versus 120min [IQR:52-265min; p<0.0001]). A significantly greater proportion of transferred patients had features of systemic envenoming on admission compared to those directly admitted (166/212 [78%] versus 5/43 [12%]; p<0.0001), and had positive clotting tests on admission (123/212 [58%] versus 10/43 [23%]; p<0.0001). Sri Lankan snakebite patients present early to hospital, but there remains a delay until antivenom administration. This delay reflects a delay in the appearance of observable or measurable features of envenoming and a lack of reliable early diagnostic tests. Improved early antivenom treatment will require reliable, rapid diagnostics for systemic envenoming.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a antiveniny $x terapeutické užití $7 D000997
- 650 _2
- $a kohortové studie $7 D015331
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a první pomoc $7 D005392
- 650 _2
- $a hospitalizace $x statistika a číselné údaje $7 D006760
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a prospektivní studie $7 D011446
- 650 _2
- $a venkovské obyvatelstvo $7 D012424
- 650 _2
- $a uštknutí hadem $x diagnóza $x epidemiologie $x terapie $7 D012909
- 650 12
- $a hadí jedy $7 D012910
- 650 _2
- $a hadi $7 D012911
- 650 _2
- $a čas zasáhnout při rozvinutí nemoci $x statistika a číselné údaje $7 D061665
- 651 _2
- $a Srí Lanka $7 D013188
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Hlusicka, Jiri $u Charles University in Prague, 1st Faculty of Medicine, 4th Department of Internal Medicine, Prague, Czech Republic
- 700 1_
- $a Siribaddana, Nipuna $u Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka
- 700 1_
- $a Waiddyanatha, Subodha $u Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka $u South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
- 700 1_
- $a Pilapitiya, Senaka $u Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka
- 700 1_
- $a Weerawansa, Prasanna $u Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka
- 700 1_
- $a Lokunarangoda, Niroshan $u Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka
- 700 1_
- $a Thalgaspitiya, Sujeewa $u Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka
- 700 1_
- $a Siribaddana, Sisira $u Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka
- 700 1_
- $a Isbister, Geoffrey K $u Monash Venom Group, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia $u South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka $u Clinical Toxicology Research Group, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia
- 773 0_
- $w MED00165375 $t PLoS neglected tropical diseases $x 1935-2735 $g Roč. 14, č. 11 (2020), s. e0008914
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33253208 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210420 $b ABA008
- 991 __
- $a 20210507104159 $b ABA008
- 999 __
- $a ok $b bmc $g 1650256 $s 1132206
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 14 $c 11 $d e0008914 $e 20201130 $i 1935-2735 $m PLoS neglected tropical diseases $n PLoS negl. trop. dis. $x MED00165375
- LZP __
- $a Pubmed-20210420
