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Comprehensive proteomic investigation of infectious and inflammatory changes in late preterm prelabour rupture of membranes
M. Vajrychová, J. Stráník, K. Pimková, M. Barman, R. Kukla, P. Zedníková, R. Bolehovská, L. Plíšková, H. Hornychová, C. Andrýs, V. Tambor, J. Lenčo, B. Jacobsson, M. Kacerovský
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
PubMed Central
od 2011
Europe PubMed Central
od 2011
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
Springer Nature OA/Free Journals
od 2011-12-01
Springer Nature - nature.com Journals - Fully Open Access
od 2011-12-01
- MeSH
- chorioamnionitida metabolismus mikrobiologie MeSH
- dospělí MeSH
- infekční komplikace v těhotenství metabolismus MeSH
- kohortové studie MeSH
- lidé MeSH
- novorozenec MeSH
- předčasný odtok plodové vody metabolismus MeSH
- proteomika metody MeSH
- těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid proteome response to the presence of MIAC and HCA in late PPROM. Protein dysregulation was associated with only five cases in the group of 15 women with confirmed MIAC and HCA. Altogether, 138 amniotic fluid proteins were changed in these five cases exclusively. These proteins were particularly associated with excessive neutrophil responses to infection, such as neutrophil degranulation and extracellular trap formation. We believe that the quantification of these proteins in amniotic fluid may assist in revealing women with the highest risk of excessive inflammatory response in late PPROM.
BIOCEV 1st Faculty of Medicine Charles University Prague Czech Republic
Biomedical Research Center University Hospital Hradec Kralove Hradec Kralove Czech Republic
Department of Metabolomics Institute of Physiology Czech Academy of Sciences Prague Czech Republic
Institute of Clinical Microbiology University Hospital Hradec Kralove Hradec Kralove Czech Republic
Citace poskytuje Crossref.org
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- $a Preterm prelabour rupture of membranes beyond the 34th week of gestation (late PPROM) is frequently associated with the risk of the microbial invasion of the amniotic fluid (MIAC) and histological chorioamnionitis (HCA). Hence, we employed a Tandem Mass Tag-based approach to uncover amniotic fluid proteome response to the presence of MIAC and HCA in late PPROM. Protein dysregulation was associated with only five cases in the group of 15 women with confirmed MIAC and HCA. Altogether, 138 amniotic fluid proteins were changed in these five cases exclusively. These proteins were particularly associated with excessive neutrophil responses to infection, such as neutrophil degranulation and extracellular trap formation. We believe that the quantification of these proteins in amniotic fluid may assist in revealing women with the highest risk of excessive inflammatory response in late PPROM.
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