-
Je něco špatně v tomto záznamu ?
Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy
T. Vandenbroucke, M. Verheecke, M. van Gerwen, K. Van Calsteren, MJ. Halaska, M. Fumagalli, R. Fruscio, A. Gandhi, M. Veening, L. Lagae, PB. Ottevanger, JU. Voigt, J. de Haan, MM. Gziri, C. Maggen, L. Mertens, G. Naulaers, L. Claes, F. Amant,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
- MeSH
- diastola účinky léků MeSH
- dítě MeSH
- dospělí MeSH
- inteligence účinky léků MeSH
- lidé MeSH
- nádorové komplikace v těhotenství farmakoterapie radioterapie MeSH
- paměť účinky léků MeSH
- předškolní dítě MeSH
- prospektivní studie MeSH
- protinádorové látky škodlivé účinky MeSH
- těhotenství MeSH
- vývoj dítěte účinky léků účinky záření MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
BACKGROUND: Data on the long-term effects of prenatal exposure to maternal cancer and its treatment on child development are scarce. METHODS: In a multicenter cohort study, the neurologic and cardiac outcomes of 6-year-old children born to women diagnosed with cancer during pregnancy were compared with the outcome of children born after an uncomplicated pregnancy. Assessment included clinical evaluation, comprehensive neuropsychological testing, electrocardiography and echocardiography. RESULTS: In total, 132 study children and 132 controls were included. In the study group, 97 children (73.5%) were prenatally exposed to chemotherapy (alone or in combination with other treatments), 14 (10.6%) to radiotherapy (alone or in combination), 1 (0.8%) to trastuzumab, 12 (9.1%) to surgery alone and 16 (12.1%) to no treatment. Although within normal ranges, statistically significant differences were found in mean verbal IQ and visuospatial long-term memory, with lower scores in the study versus control group (98.1, 95% confidence interval [CI]: 94.5-101.8, versus 104.4, 95% CI: 100.4-108.4, P = 0.001, Q < 0.001 [Q refers to the false discovery rate adjusted P value], and 3.9, 95% CI: 3.6-4.3, versus 4.5, 95% CI: 4.1-4.9, P = 0.005, Q = 0.045, respectively). A significant difference in diastolic blood pressure was found, with higher values in chemotherapy-exposed (61.1, 95% CI: 59.0 to 63.2) versus control children (56.0, 95% CI 54.1 to 57.8) (P < 0.001, Q < 0.001) and in a subgroup of 59 anthracycline-exposed (61.8, 95% CI: 59.3 to 64.4) versus control children (55.9, 95% CI: 53.6 to 58.1) (P < 0.001, Q = 0.02). CONCLUSIONS: Children prenatally exposed to maternal cancer and its treatment are at risk for lower verbal IQ and visuospatial long-term memory scores and for higher diastolic blood pressure, but other cognitive functions and cardiac outcomes were normal at the age of 6 years. CLINICAL TRIAL REGISTRATION: The study is registered at ClinicalTrials.gov, NCT00330447.
Clinic of Obstetrics and Gynecology University of Milan Bicocca and San Gerardo Hospital Monza Italy
Data Scientist Knowledge Center SD Worx Antwerp Belgium
Department of Cardiology The Hospital for Sick Children University of Toronto Toronto ON Canada
Department of Cardiology University Hospitals Leuven Leuven Belgium
Department of Clinical Sciences and Community Health University of Milan Milan Italy
Department of Development and Regeneration KU Leuven Leuven Belgium
Department of Internal Medicine Radboud UMC Nijmegen the Netherlands
Department of Neonatology University Hospitals Leuven Leuven Belgium
Department of Obstetrics and Gynecology 3rd Medical Faculty Charles University Prague Czech Republic
Department of Obstetrics and Gynecology University Hospitals Leuven Leuven Belgium
Department of Obstetrics Cliniques Universitaires St Luc Brussels Belgium
Department of Oncology KU Leuven Leuven Belgium
Department of Pediatrics University Hospitals Leuven Leuven Belgium
Department of Public Health and Primary Care Faculty of Medicine KU Leuven Leuven Belgium
Faculty Hospital Kralovske Vinohrady Prague Czech Republic
Faculty of Psychology and Educational Sciences KU Leuven Leuven Belgium
Neonatal Intensive Care Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy
Princess Máxima Center for Pediatric Oncology Utrecht the Netherlands
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21012070
- 003
- CZ-PrNML
- 005
- 20210507102132.0
- 007
- ta
- 008
- 210420s2020 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ejca.2020.07.004 $2 doi
- 035 __
- $a (PubMed)32858478
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Vandenbroucke, Tineke $u Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium
- 245 10
- $a Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy / $c T. Vandenbroucke, M. Verheecke, M. van Gerwen, K. Van Calsteren, MJ. Halaska, M. Fumagalli, R. Fruscio, A. Gandhi, M. Veening, L. Lagae, PB. Ottevanger, JU. Voigt, J. de Haan, MM. Gziri, C. Maggen, L. Mertens, G. Naulaers, L. Claes, F. Amant, International Network on Cancer, Infertility and Pregnancy (INCIP)
- 520 9_
- $a BACKGROUND: Data on the long-term effects of prenatal exposure to maternal cancer and its treatment on child development are scarce. METHODS: In a multicenter cohort study, the neurologic and cardiac outcomes of 6-year-old children born to women diagnosed with cancer during pregnancy were compared with the outcome of children born after an uncomplicated pregnancy. Assessment included clinical evaluation, comprehensive neuropsychological testing, electrocardiography and echocardiography. RESULTS: In total, 132 study children and 132 controls were included. In the study group, 97 children (73.5%) were prenatally exposed to chemotherapy (alone or in combination with other treatments), 14 (10.6%) to radiotherapy (alone or in combination), 1 (0.8%) to trastuzumab, 12 (9.1%) to surgery alone and 16 (12.1%) to no treatment. Although within normal ranges, statistically significant differences were found in mean verbal IQ and visuospatial long-term memory, with lower scores in the study versus control group (98.1, 95% confidence interval [CI]: 94.5-101.8, versus 104.4, 95% CI: 100.4-108.4, P = 0.001, Q < 0.001 [Q refers to the false discovery rate adjusted P value], and 3.9, 95% CI: 3.6-4.3, versus 4.5, 95% CI: 4.1-4.9, P = 0.005, Q = 0.045, respectively). A significant difference in diastolic blood pressure was found, with higher values in chemotherapy-exposed (61.1, 95% CI: 59.0 to 63.2) versus control children (56.0, 95% CI 54.1 to 57.8) (P < 0.001, Q < 0.001) and in a subgroup of 59 anthracycline-exposed (61.8, 95% CI: 59.3 to 64.4) versus control children (55.9, 95% CI: 53.6 to 58.1) (P < 0.001, Q = 0.02). CONCLUSIONS: Children prenatally exposed to maternal cancer and its treatment are at risk for lower verbal IQ and visuospatial long-term memory scores and for higher diastolic blood pressure, but other cognitive functions and cardiac outcomes were normal at the age of 6 years. CLINICAL TRIAL REGISTRATION: The study is registered at ClinicalTrials.gov, NCT00330447.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a protinádorové látky $x škodlivé účinky $7 D000970
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a vývoj dítěte $x účinky léků $x účinky záření $7 D002657
- 650 _2
- $a předškolní dítě $7 D002675
- 650 _2
- $a diastola $x účinky léků $7 D003971
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a inteligence $x účinky léků $7 D007360
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a paměť $x účinky léků $7 D008568
- 650 _2
- $a těhotenství $7 D011247
- 650 _2
- $a nádorové komplikace v těhotenství $x farmakoterapie $x radioterapie $7 D011252
- 650 _2
- $a prospektivní studie $7 D011446
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Verheecke, Magali $u Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium
- 700 1_
- $a van Gerwen, Mathilde $u Center for Gynecologic Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
- 700 1_
- $a Van Calsteren, Kristel $u Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Leuven, Belgium
- 700 1_
- $a Halaska, Michael J $u Department of Obstetrics and Gynecology, 3rd Medical Faculty Charles University, Prague, Czech Republic; Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic
- 700 1_
- $a Fumagalli, Monica $u Neonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
- 700 1_
- $a Fruscio, Robert $u Clinic of Obstetrics and Gynecology, University of Milan-Bicocca and San Gerardo Hospital, Monza, Italy
- 700 1_
- $a Gandhi, Amarendra $u Department of Public Health and Primary Care, Faculty of Medicine, KU Leuven, Leuven, Belgium; Data Scientist, Knowledge Center, SD Worx, Antwerp, Belgium
- 700 1_
- $a Veening, Margreet $u Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
- 700 1_
- $a Lagae, Lieven $u Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium
- 700 1_
- $a Ottevanger, Petronella B $u Department of Internal Medicine, Radboud UMC Nijmegen, the Netherlands
- 700 1_
- $a Voigt, Jens-Uwe $u Department of Cardiology, University Hospitals Leuven, Leuven, Belgium
- 700 1_
- $a de Haan, Jorine $u Department of Obstetrics and Gynecology, Amsterdam UMC, Location VU University Medical Center, the Netherlands
- 700 1_
- $a Gziri, Mina M $u Department of Obstetrics, Cliniques Universitaires St Luc, Brussels, Belgium
- 700 1_
- $a Maggen, Charlotte $u Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium
- 700 1_
- $a Mertens, Luc $u Department of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
- 700 1_
- $a Naulaers, Gunnar $u Department of Neonatology, University Hospitals Leuven, Leuven, Belgium
- 700 1_
- $a Claes, Laurence $u Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium
- 700 1_
- $a Amant, Frédéric $u Department of Oncology, KU Leuven, Leuven, Belgium; Center for Gynecologic Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands; Department of Obstetrics and Gynecology, Amsterdam UMC, Location Amsterdam Medical Center and University of Amsterdam, the Netherlands. Electronic address: frederic.amant@uzleuven.be
- 710 2_
- $a International Network on Cancer, Infertility and Pregnancy (INCIP)
- 773 0_
- $w MED00009626 $t European journal of cancer (Oxford, England : 1990) $x 1879-0852 $g Roč. 138, č. - (2020), s. 57-67
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32858478 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210420 $b ABA008
- 991 __
- $a 20210507102131 $b ABA008
- 999 __
- $a ok $b bmc $g 1650450 $s 1132449
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 138 $c - $d 57-67 $e 20200825 $i 1879-0852 $m European journal of cancer $n Eur J Cancer $x MED00009626
- LZP __
- $a Pubmed-20210420
