Conducting polymers (CP) can be used as pH- and/or electro-responsive components in various bioapplications, for example, in 4D smart scaffolds. The ability of CP to maintain conductivity under physiological conditions is, therefore, their crucial property. Unfortunately, the conductivity of the CP rapidly decreases in physiological environment, as their conducting salts convert to non-conducting bases. One of the promising solutions how to cope with this shortcoming is the use of alternative "doping" process that is not based on the protonation of CP with acids but on interactions relying in acidic hydrogen bonding. Therefore, the phosphonates (dimethyl phosphonate, diethyl phosphonate, dibutyl phosphonate, or diphenyl phosphonate) were used to re-dope two most common representatives of CP, polyaniline (PANI) and polypyrrole (PPy) bases. As a result, PANI doped with organic phosphonates proved to have significantly better stability of conductivity under different pH. It has also been shown that cytotoxicity of studied materials determined on embryonic stem cells and their embryotoxicity, determined as the impact on cardiomyogenesis and erythropoiesis, depend both on the polymer and phosphonate types used. With the exception of PANI doped with dibutyl phosphonate, all PPy-based phosphonates showed better biocompatibility than the phosphonates based on PANI.

Centre of Polymer Systems Tomas Bata University in Zlin 760 01 Zlin Czech Republic

Department of Experimental Biology Faculty of Science Masaryk University 625 00 Brno Czech Republic

Faculty of Technology Tomas Bata University in Zlin 760 01 Zlin Czech Republic

Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic 162 06 Prague 6 Czech Republic

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$a Capáková, Zdenka $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic

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$a The biocompatibility of polyaniline and polypyrrole 2: Doping with organic phosphonates / $c Z. Capáková, KA. Radaszkiewicz, U. Acharya, TH. Truong, J. Pacherník, P. Bober, V. Kašpárková, J. Stejskal, J. Pfleger, M. Lehocký, P. Humpolíček

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$a Conducting polymers (CP) can be used as pH- and/or electro-responsive components in various bioapplications, for example, in 4D smart scaffolds. The ability of CP to maintain conductivity under physiological conditions is, therefore, their crucial property. Unfortunately, the conductivity of the CP rapidly decreases in physiological environment, as their conducting salts convert to non-conducting bases. One of the promising solutions how to cope with this shortcoming is the use of alternative "doping" process that is not based on the protonation of CP with acids but on interactions relying in acidic hydrogen bonding. Therefore, the phosphonates (dimethyl phosphonate, diethyl phosphonate, dibutyl phosphonate, or diphenyl phosphonate) were used to re-dope two most common representatives of CP, polyaniline (PANI) and polypyrrole (PPy) bases. As a result, PANI doped with organic phosphonates proved to have significantly better stability of conductivity under different pH. It has also been shown that cytotoxicity of studied materials determined on embryonic stem cells and their embryotoxicity, determined as the impact on cardiomyogenesis and erythropoiesis, depend both on the polymer and phosphonate types used. With the exception of PANI doped with dibutyl phosphonate, all PPy-based phosphonates showed better biocompatibility than the phosphonates based on PANI.

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$a Radaszkiewicz, Katarzyna Anna $u Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic

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$a Acharya, Udit $u Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic

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$a Truong, Thanh Huong $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic

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$a Pacherník, Jiří $u Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic

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$a Bober, Patrycja $u Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic

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$a Kašpárková, Věra $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic

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$a Stejskal, Jaroslav $u Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic

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$a Pfleger, Jiří $u Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic

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$a Lehocký, Marián $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic

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$a Humpolíček, Petr $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic. Electronic address: humpolicek@utb.cz

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