Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Dialysis therapy is associated with peripheral marginal zone B-cell augmentation

L. Stranavova, P. Hruba, J. Slatinska, B. Sawitzki, P. Reinke, HD. Volk, O. Viklicky

. 2020 ; 60 (-) : 101289. [pub] 20200327

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012554

Grantová podpora
NV17-28778A MZ0 CEP - Centrální evidence projektů

Chronic kidney disease stage 5 (CKD5) dialysis patients who stay long term in uremic environment often exhibit several, poorly defined, immune impairments. In this study, we assessed peripheral virus-specific effector/memory cells and subpopulations of T, B and DC cells using ELISPOT and FACS methods in 74 low-risk kidney transplant candidates without anti-HLA antibodies, prior to transplantation in pre-emptive (never experienced dialysis) and dialysis cohorts. There was difference in circulating marginal zone B cells (MZB) (IgDhighCD27high) between dialysis patients and those receiving kidney grafts pre-emptively (P = .002). Patients treated on dialysis >12 months had also 4.2-fold greater risk of increased absolute numbers of MZB (95%CI:1.6-11.2; P = .004). There were no other differences in B-, T- and DC-cell subsets. Numbers of effector/memory T cells reactive to major opportunistic virus-specific antigens (CMV, BKV and EBV) were not affected by dialysis. Non-sensitised dialysis-treated patients displayed significantly more circulating MZB compared to those CKD5 patients that had never undergone dialysis therapy.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21012554
003      
CZ-PrNML
005      
20210507105000.0
007      
ta
008      
210420s2020 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.trim.2020.101289 $2 doi
035    __
$a (PubMed)32229239
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Stranavova, Lucia $u Transplant Laboratory, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic
245    10
$a Dialysis therapy is associated with peripheral marginal zone B-cell augmentation / $c L. Stranavova, P. Hruba, J. Slatinska, B. Sawitzki, P. Reinke, HD. Volk, O. Viklicky
520    9_
$a Chronic kidney disease stage 5 (CKD5) dialysis patients who stay long term in uremic environment often exhibit several, poorly defined, immune impairments. In this study, we assessed peripheral virus-specific effector/memory cells and subpopulations of T, B and DC cells using ELISPOT and FACS methods in 74 low-risk kidney transplant candidates without anti-HLA antibodies, prior to transplantation in pre-emptive (never experienced dialysis) and dialysis cohorts. There was difference in circulating marginal zone B cells (MZB) (IgDhighCD27high) between dialysis patients and those receiving kidney grafts pre-emptively (P = .002). Patients treated on dialysis >12 months had also 4.2-fold greater risk of increased absolute numbers of MZB (95%CI:1.6-11.2; P = .004). There were no other differences in B-, T- and DC-cell subsets. Numbers of effector/memory T cells reactive to major opportunistic virus-specific antigens (CMV, BKV and EBV) were not affected by dialysis. Non-sensitised dialysis-treated patients displayed significantly more circulating MZB compared to those CKD5 patients that had never undergone dialysis therapy.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a B-lymfocyty $x imunologie $7 D001402
650    _2
$a dendritické buňky $x imunologie $7 D003713
650    _2
$a dialýza $7 D003956
650    _2
$a ELISPOT $7 D058501
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a imunologická paměť $7 D007156
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a chronická renální insuficience $x imunologie $x terapie $7 D051436
650    _2
$a slezina $x patologie $7 D013154
650    _2
$a T-lymfocyty $x imunologie $7 D013601
650    _2
$a antigeny CD27 $x metabolismus $7 D018127
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Hruba, Petra $u Transplant Laboratory, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic
700    1_
$a Slatinska, Janka $u Department of Nephrology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic
700    1_
$a Sawitzki, Birgit $u BIH Centre for Regenerative Therapies, Berlin Centre for Advanced Therapies, Charité University Medicine Berlin, Berlin, Germany
700    1_
$a Reinke, Petra $u BIH Centre for Regenerative Therapies, Berlin Centre for Advanced Therapies, Charité University Medicine Berlin, Berlin, Germany
700    1_
$a Volk, Hans-Dieter $u BIH Centre for Regenerative Therapies, Berlin Centre for Advanced Therapies, Charité University Medicine Berlin, Berlin, Germany
700    1_
$a Viklicky, Ondrej $u Transplant Laboratory, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic; Department of Nephrology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic. Electronic address: ondrej.viklicky@ikem.cz
773    0_
$w MED00006022 $t Transplant immunology $x 1878-5492 $g Roč. 60, č. - (2020), s. 101289
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32229239 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20210507104958 $b ABA008
999    __
$a ok $b bmc $g 1650842 $s 1132933
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 60 $c - $d 101289 $e 20200327 $i 1878-5492 $m Transplant immunology $n Transpl Immunol $x MED00006022
GRA    __
$a NV17-28778A $p MZ0
LZP    __
$a Pubmed-20210420

Najít záznam

Citační ukazatele

Možnosti archivace