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Coumarin Tröger's base derivatives with cyanine substitution as selective and sensitive fluorescent lysosomal probes

V. Talianová, T. Bříza, L. Krčová, B. Dolenský, J. Králová, P. Martásek, V. Král, M. Havlík

. 2020 ; 94 (-) : 103447. [pub] 20191125

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012935

The fluorescent probes based on Tröger's base motive with both coumarin and cyanine substitution 11-13 have been synthesized by multi-step synthesis in high overall yields. Intracellular localization of prepared probes have been tested using four different cell lines (HF-P4, BLM, U-2 OS and A-2058). Prepared probes have intensive green and red fluorescence. Co-localization with commercial lysosome specific marker LysoTracker Blue DND 22 has been confirmed that all prepared fluorescent probes labeled lysosomal compartment with high selectivity and probes show excellent brightness at low concentration.

Citace poskytuje Crossref.org

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$a The fluorescent probes based on Tröger's base motive with both coumarin and cyanine substitution 11-13 have been synthesized by multi-step synthesis in high overall yields. Intracellular localization of prepared probes have been tested using four different cell lines (HF-P4, BLM, U-2 OS and A-2058). Prepared probes have intensive green and red fluorescence. Co-localization with commercial lysosome specific marker LysoTracker Blue DND 22 has been confirmed that all prepared fluorescent probes labeled lysosomal compartment with high selectivity and probes show excellent brightness at low concentration.
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$a Dolenský, Bohumil $u Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic
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$a Martásek, Pavel $u Department of Paediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 121 08 Prague, Czech Republic
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$a Havlík, Martin $u BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic. Electronic address: martin.havlik@lf1.cuni.cz
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