-
Je něco špatně v tomto záznamu ?
Coumarin Tröger's base derivatives with cyanine substitution as selective and sensitive fluorescent lysosomal probes
V. Talianová, T. Bříza, L. Krčová, B. Dolenský, J. Králová, P. Martásek, V. Král, M. Havlík
Bioorganic chemistry.
2020 ;
94 (-) :
103447.
[pub] 20191125
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc21012935
- MeSH
- fluorescenční barviva chemická syntéza chemie MeSH
- fluorescenční mikroskopie MeSH
- karbocyaniny chemie MeSH
- kultivované buňky MeSH
- kumariny chemická syntéza chemie MeSH
- lidé MeSH
- lyzozomy chemie MeSH
- molekulární struktura MeSH
- optické zobrazování * MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The fluorescent probes based on Tröger's base motive with both coumarin and cyanine substitution 11-13 have been synthesized by multi-step synthesis in high overall yields. Intracellular localization of prepared probes have been tested using four different cell lines (HF-P4, BLM, U-2 OS and A-2058). Prepared probes have intensive green and red fluorescence. Co-localization with commercial lysosome specific marker LysoTracker Blue DND 22 has been confirmed that all prepared fluorescent probes labeled lysosomal compartment with high selectivity and probes show excellent brightness at low concentration.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21012935
- 003
- CZ-PrNML
- 005
- 20210507101657.0
- 007
- ta
- 008
- 210420s2020 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.bioorg.2019.103447 $2 doi
- 035 __
- $a (PubMed)31810756
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Talianová, Veronika $u BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic
- 245 10
- $a Coumarin Tröger's base derivatives with cyanine substitution as selective and sensitive fluorescent lysosomal probes / $c V. Talianová, T. Bříza, L. Krčová, B. Dolenský, J. Králová, P. Martásek, V. Král, M. Havlík
- 520 9_
- $a The fluorescent probes based on Tröger's base motive with both coumarin and cyanine substitution 11-13 have been synthesized by multi-step synthesis in high overall yields. Intracellular localization of prepared probes have been tested using four different cell lines (HF-P4, BLM, U-2 OS and A-2058). Prepared probes have intensive green and red fluorescence. Co-localization with commercial lysosome specific marker LysoTracker Blue DND 22 has been confirmed that all prepared fluorescent probes labeled lysosomal compartment with high selectivity and probes show excellent brightness at low concentration.
- 650 _2
- $a karbocyaniny $x chemie $7 D002232
- 650 _2
- $a kultivované buňky $7 D002478
- 650 _2
- $a kumariny $x chemická syntéza $x chemie $7 D003374
- 650 _2
- $a vztah mezi dávkou a účinkem léčiva $7 D004305
- 650 _2
- $a fluorescenční barviva $x chemická syntéza $x chemie $7 D005456
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a lyzozomy $x chemie $7 D008247
- 650 _2
- $a fluorescenční mikroskopie $7 D008856
- 650 _2
- $a molekulární struktura $7 D015394
- 650 12
- $a optické zobrazování $7 D061848
- 650 _2
- $a vztahy mezi strukturou a aktivitou $7 D013329
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Bříza, Tomáš $u BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic
- 700 1_
- $a Krčová, Lucie $u BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic
- 700 1_
- $a Dolenský, Bohumil $u Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic
- 700 1_
- $a Králová, Jarmila $u BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Paediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 121 08 Prague, Czech Republic
- 700 1_
- $a Martásek, Pavel $u Department of Paediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 121 08 Prague, Czech Republic
- 700 1_
- $a Král, Vladimír $u BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic
- 700 1_
- $a Havlík, Martin $u BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic. Electronic address: martin.havlik@lf1.cuni.cz
- 773 0_
- $w MED00000771 $t Bioorganic chemistry $x 1090-2120 $g Roč. 94, č. - (2020), s. 103447
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31810756 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210420 $b ABA008
- 991 __
- $a 20210507101657 $b ABA008
- 999 __
- $a ok $b bmc $g 1651167 $s 1133314
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 94 $c - $d 103447 $e 20191125 $i 1090-2120 $m Bioorganic chemistry $n Bioorg Chem $x MED00000771
- LZP __
- $a Pubmed-20210420
