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Kardioglykosidy: terapeutický potenciál pro léčbu nádorových onemocnění
[Cardiac glycosides: on their therapeutic potential for cancer treatment]

Jiří Bejček, Vojtěch Spiwok, Eva Kmoníčková, Tomáš Ruml, Silvie Rimpelová

. 2021 ; 115 (1) : 4-12.

Status minimální Jazyk čeština Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc21016439

Cardiac glycosides are bioactive natural compounds well-known mainly for their potency to induce a cardiotonic effect by sodium-potassium ATPase inhibition. For many years, cardiac glycosides have been utilized to treat heart failure and arrhythmias; however, according to novel research studies, these compounds have an enormous potential also as medicinally promising compounds for cancer treatment. The goal of this review is to provide a brief insight into the research topic of cardiac glycosides by describing their chemical structure, biosynthesis, the mechanism of action, anticancer potential alongside with the most significant clinical trials, as well as their other biological activities, such as the modulation of the immune system.

Cardiac glycosides: on their therapeutic potential for cancer treatment

Bibliografie atd.

Literatura

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$a Cardiac glycosides are bioactive natural compounds well-known mainly for their potency to induce a cardiotonic effect by sodium-potassium ATPase inhibition. For many years, cardiac glycosides have been utilized to treat heart failure and arrhythmias; however, according to novel research studies, these compounds have an enormous potential also as medicinally promising compounds for cancer treatment. The goal of this review is to provide a brief insight into the research topic of cardiac glycosides by describing their chemical structure, biosynthesis, the mechanism of action, anticancer potential alongside with the most significant clinical trials, as well as their other biological activities, such as the modulation of the immune system.
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