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Femoral bone defect healing using two novel biocompatible degradable materials
Robert Srnec, Andrea Nečasová, Pavel Proks, Miša Škorič, Zita Filipejová, Lucy Vojtová, Alois Nečas
Jazyk angličtina Země Česko
Typ dokumentu práce podpořená grantem, klinická studie
- MeSH
- autologní štěp chirurgie MeSH
- biokompatibilní materiály * klasifikace terapeutické užití MeSH
- fraktury femuru * diagnostické zobrazování terapie veterinární MeSH
- prasata chirurgie MeSH
- radiografie metody MeSH
- vnitřní fixace fraktury metody veterinární MeSH
- výzkum MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- klinická studie MeSH
- práce podpořená grantem MeSH
This study was conducted as an in vivo experiment in adult miniature pigs with the aim to test two new biomaterials. An iatrogenic defect was made into the central femoral diaphysis in the experimental animals and subsequently fixated by bridging plate osteosynthesis. Into the defect we implanted a cancellous autograft (control group), a pasty injectable scaffold (EXP A), and a porous 3D cylinder (EXP B). Radiological examination was performed in all animals at 0, 10, 20, 30 weeks after surgical procedure and histological assessment was performed. In the newly formed bone the osteoblastic activity was monitored. In terms of radiology, the most effective method was observed in the control group (completely healed 100%) compared to experimental groups EXP A (70.0%) and EXP B (62.5%). Histological assessment showed a higher cell count in the place of bone defect in the control group compared to experimental groups. Between the experimental groups, a higher count of bone marrow cells was found in group EXP B. Both newly developed biomaterials seem to be suitable as replacements for large bone defects, having good workability and applicability. However, compared to the control group treated with a cancellous autograft, the newly formed bone did not reach the same number of cells settling in and in some cases, full radiological healing was not reached. Nevertheless, the material was found to be grown into the original bone in all cases within the experimental groups. The new biomaterials have a great potential as a substitute in the treatment of large bone defects.
Citace poskytuje Crossref.org
Literatura
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