• Je něco špatně v tomto záznamu ?

Epidemic HI2 Plasmids Mobilising the Carbapenemase Gene blaIMP-4 in Australian Clinical Samples Identified in Multiple Sublineages of Escherichia coli ST216 Colonising Silver Gulls

H. Tarabai, ER. Wyrsch, I. Bitar, M. Dolejska, SP. Djordjevic

. 2021 ; 9 (3) : . [pub] 20210310

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21018188

Grantová podpora
18-23532S Grantová Agentura České Republiky
LQ1601 Central European Institute of Technology
Q39 Grantová Agentura, Univerzita Karlova
CZ.02.1.01/0.0/0.0/16_019/0000787 Ministry of Education Youth and Sports of the Czech Republic
IMA: 2019-FVHE-51 Veterinární a Farmaceutická Univerzita Brno
MRFF75873 Medical Research Future Fund Frontier Health and Medical Research Program

Escherichia coli ST216, including those that carry blaKPC-2, blaFOX-5, blaCTX-M-15 and mcr-1, have been linked to wild and urban-adapted birds and the colonisation of hospital environments causing recalcitrant, carbapenem-resistant human infections. Here we sequenced 22 multiple-drug resistant ST216 isolates from Australian silver gull chicks sampled from Five Islands, of which 21 carried nine or more antibiotic resistance genes including blaIMP-4 (n = 21), blaTEM-1b (n = 21), aac(3)-IId (n = 20), mph(A) (n = 20), catB3 (n = 20), sul1 (n = 20), aph(3")-Ib (n = 18) and aph(6)-Id (n = 18) on FIB(K) (n = 20), HI2-ST1 (n = 11) and HI2-ST3 (n = 10) plasmids. We show that (i) all HI2 plasmids harbour blaIMP-4 in resistance regions containing In809 flanked by IS26 (HI2-ST1) or IS15DI (HI2-ST3) and diverse metal resistance genes; (ii) HI2-ST1 plasmids are highly related to plasmids reported in diverse Enterobacteriaceae sourced from humans, companion animals and wildlife; (iii) HI2 were a feature of the Australian gull isolates and were not observed in international ST216 isolates. Phylogenetic analyses identified close relationships between ST216 from Australian gull and clinical isolates from overseas. E. coli ST216 from Australian gulls harbour HI2 plasmids encoding resistance to clinically important antibiotics and metals. Our studies underscore the importance of adopting a one health approach to AMR and pathogen surveillance.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21018188
003      
CZ-PrNML
005      
20210729104148.0
007      
ta
008      
210726s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/microorganisms9030567 $2 doi
035    __
$a (PubMed)33801844
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Tarabai, Hassan $u Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno 612 42, Czech Republic $u Central European Institute of Technology (CEITEC), University of Veterinary and Pharmaceutical Sciences Brno, Brno 612 42, Czech Republic
245    10
$a Epidemic HI2 Plasmids Mobilising the Carbapenemase Gene blaIMP-4 in Australian Clinical Samples Identified in Multiple Sublineages of Escherichia coli ST216 Colonising Silver Gulls / $c H. Tarabai, ER. Wyrsch, I. Bitar, M. Dolejska, SP. Djordjevic
520    9_
$a Escherichia coli ST216, including those that carry blaKPC-2, blaFOX-5, blaCTX-M-15 and mcr-1, have been linked to wild and urban-adapted birds and the colonisation of hospital environments causing recalcitrant, carbapenem-resistant human infections. Here we sequenced 22 multiple-drug resistant ST216 isolates from Australian silver gull chicks sampled from Five Islands, of which 21 carried nine or more antibiotic resistance genes including blaIMP-4 (n = 21), blaTEM-1b (n = 21), aac(3)-IId (n = 20), mph(A) (n = 20), catB3 (n = 20), sul1 (n = 20), aph(3")-Ib (n = 18) and aph(6)-Id (n = 18) on FIB(K) (n = 20), HI2-ST1 (n = 11) and HI2-ST3 (n = 10) plasmids. We show that (i) all HI2 plasmids harbour blaIMP-4 in resistance regions containing In809 flanked by IS26 (HI2-ST1) or IS15DI (HI2-ST3) and diverse metal resistance genes; (ii) HI2-ST1 plasmids are highly related to plasmids reported in diverse Enterobacteriaceae sourced from humans, companion animals and wildlife; (iii) HI2 were a feature of the Australian gull isolates and were not observed in international ST216 isolates. Phylogenetic analyses identified close relationships between ST216 from Australian gull and clinical isolates from overseas. E. coli ST216 from Australian gulls harbour HI2 plasmids encoding resistance to clinically important antibiotics and metals. Our studies underscore the importance of adopting a one health approach to AMR and pathogen surveillance.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Wyrsch, Ethan R $u iThree Institute, University of Technology Sydney, Sydney, NSW 2007, Australia
700    1_
$a Bitar, Ibrahim $u Central European Institute of Technology (CEITEC), University of Veterinary and Pharmaceutical Sciences Brno, Brno 612 42, Czech Republic $u Biomedical Center, Faculty of medicine in Pilsen, Charles University, Pilsen 323 00, Czech Republic
700    1_
$a Dolejska, Monika $u Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno 612 42, Czech Republic $u Central European Institute of Technology (CEITEC), University of Veterinary and Pharmaceutical Sciences Brno, Brno 612 42, Czech Republic $u Biomedical Center, Faculty of medicine in Pilsen, Charles University, Pilsen 323 00, Czech Republic $u Department of Clinical Microbiology and Immunology, Institute of Laboratory Medicine, The University Hospital Brno, Brno 625 00, Czech Republic
700    1_
$a Djordjevic, Steven P $u iThree Institute, University of Technology Sydney, Sydney, NSW 2007, Australia
773    0_
$w MED00198767 $t Microorganisms $x 2076-2607 $g Roč. 9, č. 3 (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33801844 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20210726 $b ABA008
991    __
$a 20210729104147 $b ABA008
999    __
$a ind $b bmc $g 1676570 $s 1138632
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 9 $c 3 $e 20210310 $i 2076-2607 $m Microorganisms $n Microorganisms $x MED00198767
GRA    __
$a 18-23532S $p Grantová Agentura České Republiky
GRA    __
$a LQ1601 $p Central European Institute of Technology
GRA    __
$a Q39 $p Grantová Agentura, Univerzita Karlova
GRA    __
$a CZ.02.1.01/0.0/0.0/16_019/0000787 $p Ministry of Education Youth and Sports of the Czech Republic
GRA    __
$a IMA: 2019-FVHE-51 $p Veterinární a Farmaceutická Univerzita Brno
GRA    __
$a MRFF75873 $p Medical Research Future Fund Frontier Health and Medical Research Program
LZP    __
$a Pubmed-20210726

Najít záznam

Citační ukazatele

    Možnosti archivace