In transdermal drug delivery applications uniform drug distribution and sustained release are of great importance to decrease the side effects. In this direction in the present research, vanillin crosslinked chitosan (CS) and polyvinyl alcohol (PVA) blend based matrix-type transdermal system was prepared by casting and drying of aqueous solutions for local delivery of enrofloxacin (ENR) drug. Subsequently, the properties including the morphology, chemical structure, thermal behavior, tensile strength, crosslinking degree, weight uniformity, thickness, swelling and drug release of the CS-PVA blend films before and after crosslinking were characterized. In vitro drug release profiles showed the sustained release of ENR by the incorporation of vanillin as a crosslinker into the CS-PVA polymer matrix. Furthermore, the release kinetic profiles revealed that the followed mechanism for all samples was Higuchi and the increase of vanillin concentration in the blend films resulted in the change of diffusion mechanism from anomalous transport to Fickian diffusion. Overall, the obtained results suggest that the investigated vanillin crosslinked CS-PVA matrix-type films are potential candidates for transdermal drug delivery system.

Centre of Polymer Systems University Institute Tomas Bata University in Zlin Trida Tomase Bati 5678 760 01 Zlin Czech Republic

Department of Chemistry Mugla Sitki Kocman University Kotekli 48000 Mugla Turkey

Department of Surface Engineering Jozef Stefan Institute Jamova cesta 39 1000 Ljubljana Slovenia

Faculty of Technology Tomas Bata University in Zlín Vavreckova 275 76001 Zlín Czech Republic

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$a Karakurt, Ilkay $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic. Electronic address: ykarakurt@utb.cz

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$a Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends / $c I. Karakurt, K. Ozaltin, E. Vargun, L. Kucerova, P. Suly, E. Harea, A. Minařík, K. Štěpánková, M. Lehocky, P. Humpolícek, A. Vesel, M. Mozetic

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$a In transdermal drug delivery applications uniform drug distribution and sustained release are of great importance to decrease the side effects. In this direction in the present research, vanillin crosslinked chitosan (CS) and polyvinyl alcohol (PVA) blend based matrix-type transdermal system was prepared by casting and drying of aqueous solutions for local delivery of enrofloxacin (ENR) drug. Subsequently, the properties including the morphology, chemical structure, thermal behavior, tensile strength, crosslinking degree, weight uniformity, thickness, swelling and drug release of the CS-PVA blend films before and after crosslinking were characterized. In vitro drug release profiles showed the sustained release of ENR by the incorporation of vanillin as a crosslinker into the CS-PVA polymer matrix. Furthermore, the release kinetic profiles revealed that the followed mechanism for all samples was Higuchi and the increase of vanillin concentration in the blend films resulted in the change of diffusion mechanism from anomalous transport to Fickian diffusion. Overall, the obtained results suggest that the investigated vanillin crosslinked CS-PVA matrix-type films are potential candidates for transdermal drug delivery system.

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$a Ozaltin, Kadir $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic. Electronic address: ozaltin@utb.cz

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$a Vargun, Elif $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic; Department of Chemistry, Mugla Sitki Kocman University, Kotekli, 48000 Mugla, Turkey. Electronic address: vargun@utb.cz

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$a Kucerova, Liliana $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic. Electronic address: l7_kucerova@utb.cz

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$a Suly, Pavol $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic. Electronic address: suly@utb.cz

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$a Harea, Evghenii $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, 76001 Zlín, Czech Republic. Electronic address: harea@utb.cz

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$a Minařík, Antonín $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, 76001 Zlín, Czech Republic. Electronic address: minarik@utb.cz

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$a Štěpánková, Kateřina $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic. Electronic address: k1_stepankova@utb.cz

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$a Lehocky, Marian $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, 76001 Zlín, Czech Republic. Electronic address: lehocky@post.cz

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$a Humpolícek, Petr $u Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 275, 76001 Zlín, Czech Republic. Electronic address: humpolicek@utb.cz

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$a Vesel, Alenka $u Department of Surface Engineering, Jozef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia. Electronic address: alenka.vesel@ijs.si

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$a Mozetic, Miran $u Department of Surface Engineering, Jozef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia. Electronic address: miran.mozetic@ijs.si

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