Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Effect of Anatomic Segment Involvement on Stereotactic Radiosurgery for Facial Nerve Schwannomas: An International Multicenter Cohort Study

GU. Mehta, GP. Lekovic, WH. Slattery, DE. Brackmann, H. Long, H. Kano, D. Kondziolka, M. Mureb, K. Bernstein, AM. Langlois, D. Mathieu, AM. Nabeel, WA. Reda, SR. Tawadros, K. Abdelkarim, AMN. El-Shehaby, RM. Emad, N. Mohammed, D. Urgosik, R....

. 2020 ; 88 (1) : E91-E98. [pub] 20201215

Language English Country United States

Document type Journal Article, Multicenter Study

Persistent link   https://www.medvik.cz/link/bmc21019652
E-resources Online Full text

NLK ProQuest Central from 2010-01-01 to 2021-12-31
Health & Medicine (ProQuest) from 2010-01-01 to 2021-12-31

Links

PubMed 32687577
DOI 10.1093/neuros/nyaa313
Knihovny.cz E-resources

BACKGROUND: Facial nerve schwannomas are rare, challenging tumors to manage due to their nerve of origin. Functional outcomes after stereotactic radiosurgery (SRS) are incompletely defined. OBJECTIVE: To analyze the effect of facial nerve segment involvement on functional outcome for these tumors. METHODS: Patients who underwent single-session SRS for facial nerve schwannomas with at least 3 mo follow-up at 11 participating centers were included. Preoperative and treatment variables were recorded. Outcome measures included radiological tumor response and neurological function. RESULTS: A total of 63 patients (34 females) were included in the present study. In total, 75% had preoperative facial weakness. Mean tumor volume and margin dose were 2.0 ± 2.4 cm3 and 12.2 ± 0.54 Gy, respectively. Mean radiological follow-up was 45.5 ± 38.9 mo. Progression-free survival at 2, 5, and 10 yr was 98.1%, 87.2%, and 87.2%, respectively. The cumulative proportion of patients with regressing tumors at 2, 5, and 10 yr was 43.1%, 63.6%, and 63.6%, respectively. The number of involved facial nerve segments significantly predicted tumor progression (P = .04). Facial nerve function was stable or improved in 57 patients (90%). Patients with involvement of the labyrinthine segment of the facial nerve were significantly more likely to have an improvement in facial nerve function after SRS (P = .03). Hearing worsened in at least 6% of patients. Otherwise, adverse radiation effects included facial twitching (3 patients), facial numbness (2 patients), and dizziness (2 patients). CONCLUSION: SRS for facial nerve schwannomas is effective and spares facial nerve function in most patients. Some patients may have functional improvement after treatment, particularly if the labyrinthine segment is involved.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019652
003      
CZ-PrNML
005      
20210830101233.0
007      
ta
008      
210728s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1093/neuros/nyaa313 $2 doi
035    __
$a (PubMed)32687577
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Mehta, Gautam U $u Division of Neurosurgery, House Ear Institute, Los Angeles, California
245    10
$a Effect of Anatomic Segment Involvement on Stereotactic Radiosurgery for Facial Nerve Schwannomas: An International Multicenter Cohort Study / $c GU. Mehta, GP. Lekovic, WH. Slattery, DE. Brackmann, H. Long, H. Kano, D. Kondziolka, M. Mureb, K. Bernstein, AM. Langlois, D. Mathieu, AM. Nabeel, WA. Reda, SR. Tawadros, K. Abdelkarim, AMN. El-Shehaby, RM. Emad, N. Mohammed, D. Urgosik, R. Liscak, CC. Lee, HC. Yang, A. Montazeripouragha, AM. Kaufmann, KC. Joshi, GH. Barnett, DM. Trifiletti, LD. Lunsford, JP. Sheehan
520    9_
$a BACKGROUND: Facial nerve schwannomas are rare, challenging tumors to manage due to their nerve of origin. Functional outcomes after stereotactic radiosurgery (SRS) are incompletely defined. OBJECTIVE: To analyze the effect of facial nerve segment involvement on functional outcome for these tumors. METHODS: Patients who underwent single-session SRS for facial nerve schwannomas with at least 3 mo follow-up at 11 participating centers were included. Preoperative and treatment variables were recorded. Outcome measures included radiological tumor response and neurological function. RESULTS: A total of 63 patients (34 females) were included in the present study. In total, 75% had preoperative facial weakness. Mean tumor volume and margin dose were 2.0 ± 2.4 cm3 and 12.2 ± 0.54 Gy, respectively. Mean radiological follow-up was 45.5 ± 38.9 mo. Progression-free survival at 2, 5, and 10 yr was 98.1%, 87.2%, and 87.2%, respectively. The cumulative proportion of patients with regressing tumors at 2, 5, and 10 yr was 43.1%, 63.6%, and 63.6%, respectively. The number of involved facial nerve segments significantly predicted tumor progression (P = .04). Facial nerve function was stable or improved in 57 patients (90%). Patients with involvement of the labyrinthine segment of the facial nerve were significantly more likely to have an improvement in facial nerve function after SRS (P = .03). Hearing worsened in at least 6% of patients. Otherwise, adverse radiation effects included facial twitching (3 patients), facial numbness (2 patients), and dizziness (2 patients). CONCLUSION: SRS for facial nerve schwannomas is effective and spares facial nerve function in most patients. Some patients may have functional improvement after treatment, particularly if the labyrinthine segment is involved.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a dítě $7 D002648
650    _2
$a kohortové studie $7 D015331
650    _2
$a nádory kraniálních nervů $x patologie $x chirurgie $7 D003390
650    _2
$a nervus facialis $x patologie $x chirurgie $7 D005154
650    _2
$a nemoci lícního nervu $x patologie $x chirurgie $7 D005155
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a neurilemom $x patologie $x chirurgie $7 D009442
650    12
$a radiochirurgie $7 D016634
650    _2
$a retrospektivní studie $7 D012189
650    12
$a výsledek terapie $7 D016896
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Lekovic, Gregory P $u Division of Neurosurgery, House Ear Institute, Los Angeles, California
700    1_
$a Slattery, William H $u Division of Neuro-otology, House Ear Institute, Los Angeles, California
700    1_
$a Brackmann, Derald E $u Division of Neuro-otology, House Ear Institute, Los Angeles, California
700    1_
$a Long, Hao $u Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
700    1_
$a Kano, Hideyuki $u Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
700    1_
$a Kondziolka, Douglas $u Department of Neurosurgery, New York University School of Medicine, New York, New York
700    1_
$a Mureb, Monica $u Department of Neurosurgery, New York University School of Medicine, New York, New York
700    1_
$a Bernstein, Kenneth $u Department of Radiation Oncology, NYU Langone Medical Center, New York, New York
700    1_
$a Langlois, Anne-Marie $u Department of Neurosurgery, Université de Sherbrooke, Centre de Recherche du CHUS, Sherbrooke, Canada
700    1_
$a Mathieu, David $u Department of Neurosurgery, Université de Sherbrooke, Centre de Recherche du CHUS, Sherbrooke, Canada
700    1_
$a Nabeel, Ahmed M $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Neurosurgery Department, Benha University, Qalubya, Egypt
700    1_
$a Reda, Wael A $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Neurosurgery Department, Ain Shams University, Cairo, Egypt
700    1_
$a Tawadros, Sameh R $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Neurosurgery Department, Ain Shams University, Cairo, Egypt
700    1_
$a Abdelkarim, Khaled $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Clinical Oncology Department, Ain Shams University, Cairo, Egypt
700    1_
$a El-Shehaby, Amr M N $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Neurosurgery Department, Ain Shams University, Cairo, Egypt
700    1_
$a Emad, Reem M $u Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt $u Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt
700    1_
$a Mohammed, Nasser $u Department of Neurosurgery, University of Virginia Medical Center, Charlottesville, Virginia
700    1_
$a Urgosik, Dusan $u Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic
700    1_
$a Liscak, Roman $u Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic
700    1_
$a Lee, Cheng-Chia $u Department of Neurosurgery, Neurologic Institute, Taipei Veterans General Hospital, Taipei, Taiwan $u School of Medicine, National Yang-Ming University, Taipei, Taiwan
700    1_
$a Yang, Huai-Che $u Department of Neurosurgery, Neurologic Institute, Taipei Veterans General Hospital, Taipei, Taiwan $u School of Medicine, National Yang-Ming University, Taipei, Taiwan
700    1_
$a Montazeripouragha, Amanallah $u Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
700    1_
$a Kaufmann, Anthony M $u Section of Neurosurgery, University of Manitoba, Winnipeg, Canada
700    1_
$a Joshi, Krishna C $u Department of Neuro-oncology, Cleveland Clinic, Cleveland, Ohio
700    1_
$a Barnett, Gene H $u Department of Neuro-oncology, Cleveland Clinic, Cleveland, Ohio
700    1_
$a Trifiletti, Daniel M $u Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida
700    1_
$a Lunsford, L Dade $u Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
700    1_
$a Sheehan, Jason P $u Department of Neurosurgery, University of Virginia Medical Center, Charlottesville, Virginia
773    0_
$w MED00003511 $t Neurosurgery $x 1524-4040 $g Roč. 88, č. 1 (2020), s. E91-E98
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32687577 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830101233 $b ABA008
999    __
$a ok $b bmc $g 1690463 $s 1140098
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 88 $c 1 $d E91-E98 $e 20201215 $i 1524-4040 $m Neurosurgery $n Neurosurgery $x MED00003511
LZP    __
$a Pubmed-20210728

Find record

Citation metrics

Archiving options