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The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice
MW. Dobenecker, J. Marcello, A. Becker, E. Rudensky, NV. Bhanu, T. Carrol, BA. Garcia, R. Prinjha, V. Yurchenko, A. Tarakhovsky
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
P01 CA196539
NCI NIH HHS - United States
R01 AI118891
NIAID NIH HHS - United States
Elsevier Open Archive Journals od 1968-07-01 do Před 1 rokem
Odkazy
PubMed
32862441
DOI
10.1002/1873-3468.13903
Knihovny.cz E-zdroje
- MeSH
- analýza přežití MeSH
- B-lymfocyty metabolismus MeSH
- histonlysin-N-methyltransferasa chemie metabolismus MeSH
- histony metabolismus MeSH
- humorální imunita MeSH
- katalytická doména * MeSH
- lysin metabolismus MeSH
- metylace MeSH
- myši inbrední C57BL MeSH
- novorozená zvířata MeSH
- přesmyk imunoglobulinových tříd MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zárodečné centrum lymfatické uzliny metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental antigens, B1 cells regulate the production of polyreactive and low-affinity antibodies for innate humoral immunity. The molecular mechanism of B-cell specification into different subsets is understudied. In this study, we identified lysine methyltransferase NSD2 (MMSET/WHSC1) as a critical regulator of B1 cell development. In contrast to its minor impact on B2 cells, deletion of the catalytic domain of NSD2 in primary B cells impairs the generation of B1 lineage. Thus, NSD2, a histone H3 K36 dimethylase, is the first-in-class epigenetic regulator of a B-cell lineage in mice.
Bioinformatics Resource Center Rockefeller University New York NY USA
Bristol Meyers Squibb Princeton NJ USA
Epinova DPU Immuno Inflammation Therapy Area GlaxoSmithKline R and D Stevenage UK
Laboratory of Immune Cell Epigenetics and Signaling Rockefeller University New York NY USA
Life Science Research Centre University of Ostrava Ostrava Czech Republic
NYU Langone Medical Center and School of Medicine New York NY USA
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- $a The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice / $c MW. Dobenecker, J. Marcello, A. Becker, E. Rudensky, NV. Bhanu, T. Carrol, BA. Garcia, R. Prinjha, V. Yurchenko, A. Tarakhovsky
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