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The CEP5 Peptide Promotes Abiotic Stress Tolerance, As Revealed by Quantitative Proteomics, and Attenuates the AUX/IAA Equilibrium in Arabidopsis

S. Smith, S. Zhu, L. Joos, I. Roberts, N. Nikonorova, LD. Vu, E. Stes, H. Cho, A. Larrieu, W. Xuan, B. Goodall, B. van de Cotte, JM. Waite, A. Rigal, S. Ramans Harborough, G. Persiau, S. Vanneste, GK. Kirschner, E. Vandermarliere, L. Martens, Y....

. 2020 ; 19 (8) : 1248-1262. [pub] 20200513

Language English Country United States

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

Persistent link   https://www.medvik.cz/link/bmc21020318

Grant support
BB/H022457/1 Biotechnology and Biological Sciences Research Council - United Kingdom
T32 HD007183 NICHD NIH HHS - United States
BB_BB/H022457/1 Biotechnology and Biological Sciences Research Council - United Kingdom

Peptides derived from non-functional precursors play important roles in various developmental processes, but also in (a)biotic stress signaling. Our (phospho)proteome-wide analyses of C-TERMINALLY ENCODED PEPTIDE 5 (CEP5)-mediated changes revealed an impact on abiotic stress-related processes. Drought has a dramatic impact on plant growth, development and reproduction, and the plant hormone auxin plays a role in drought responses. Our genetic, physiological, biochemical, and pharmacological results demonstrated that CEP5-mediated signaling is relevant for osmotic and drought stress tolerance in Arabidopsis, and that CEP5 specifically counteracts auxin effects. Specifically, we found that CEP5 signaling stabilizes AUX/IAA transcriptional repressors, suggesting the existence of a novel peptide-dependent control mechanism that tunes auxin signaling. These observations align with the recently described role of AUX/IAAs in stress tolerance and provide a novel role for CEP5 in osmotic and drought stress tolerance.

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$a Zhu, Shanshuo $u Department of Plant Biotechnology and Bioinformatics, Ghent University, Belgium; VIB Center for Plant Systems Biology, Ghent, Belgium; VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
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$a Cho, Hyunwoo $u Department of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology, Pohang, Republic of Korea
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$a Felix, Georg $u Zentrum für Molekularbiologie der Pflanzen, Plant Biochemistry, University Tübingen, Tübingen, Germany
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$a Bennett, Malcolm J $u Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough, United Kingdom; Centre for Plant Integrative Biology, University of Nottingham, Loughborough, United Kingdom
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