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In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry: sex differences
M. Grecu, C. Blomström-Lundqvist, J. Kautzner, C. Laroche, IC. Van Gelder, L. Jordaens, L. Tavazzi, R. Cihak, JM. Rubio Campal, Z. Kalarus, E. Pokushalov, J. Brugada, N. Dagres, E. Arbelo, ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed Central od 2008
Open Access Digital Library od 1999-01-01
Medline Complete (EBSCOhost) od 1999-01-01
Oxford Journals Open Access Collection od 1999-01-01
Odkazy
PubMed
31504431
DOI
10.1093/europace/euz225
Knihovny.cz E-zdroje
- MeSH
- fibrilace síní * diagnóza epidemiologie chirurgie MeSH
- katetrizační ablace * škodlivé účinky MeSH
- lidé MeSH
- následné studie MeSH
- nemocnice MeSH
- pohlavní dimorfismus MeSH
- prospektivní studie MeSH
- recidiva MeSH
- registrace MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
AIM: The purpose of this study was to compare sex differences of atrial fibrillation (AF) catheter ablation (CA) and to analyse the opportunities for improved outcomes. METHODS AND RESULTS: All data were collected from the Atrial Fibrillation Ablation Long-Term registry, a prospective, multinational study conducted by the ESC-EORP European Heart Rhythm Association (EHRA) under the EURObservational Research Programme (ESC-EORP). A total of 104 centres in 27 European countries participated. Of 3593 included patients, 1146 (31.9%) were female. Female patients were older (61.0 vs. 56.4 years; P < 0.001), had more comorbidities (hypertension, diabetes, and obesity), more episodes of arrhythmias per month (6.9 vs. 6.2; P < 0.001), and a higher average EHRA score (2.6 vs. 2.4; P < 0.001). The duration of the procedure was shorter in females (160.1 min vs. 167.9 min; P < 0.001), irrespective of additional ablation lesions added to pulmonary vein isolation. Overall cardiovascular complications were more frequent in women than in men (5.7% vs. 3.4%; P < 0.001). Furthermore, cardiac perforations (3.8% vs. 1.3%; P = 0.011) and neurological complications (2.2% vs. 0.3%; P = 0.004) were found in females in less experienced centres than in experienced ones. On a final note, at 12 months, AF recurrence rate was similar in females and males (34.4% vs. 34.2%; P = 0.897), but more females were still on antiarrhythmic drugs (50.6% vs. 44.1%; P < 0.001) when compared with men. CONCLUSION: Females underwent CA procedures for AF less frequently than males throughout Europe, despite more recurrent symptoms. With the same success rate, severe acute complications remained considerable in females, especially in less experienced centres.
Cardiology Department Fundación Jiménez Díaz Quirón Salud Madrid Spain
Cardiology Department Institute for Clinical and Experimental Medicine Prague Czech Republic
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares Madrid Spain
Department of Cardiology and Medical Science Uppsala University Uppsala Sweden
Department of Electrophysiology Cardiovascular Diseases Institute Iasi Romania
Department of Electrophysiology Heart Center Leipzig University of Leipzig Leipzig Germany
Erasmus Medical Center Clinical Electrophysiology Rotterdam The Netherlands
EURObservational Research Programme European Society of Cardiology Sophia Antipolis France
IDIBAPS Institut d'Investigació August Pi i Sunyer Barcelona Spain
Maria Cecilia Hospital GVM Care and Research Cotignola Italy
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- $a AIM: The purpose of this study was to compare sex differences of atrial fibrillation (AF) catheter ablation (CA) and to analyse the opportunities for improved outcomes. METHODS AND RESULTS: All data were collected from the Atrial Fibrillation Ablation Long-Term registry, a prospective, multinational study conducted by the ESC-EORP European Heart Rhythm Association (EHRA) under the EURObservational Research Programme (ESC-EORP). A total of 104 centres in 27 European countries participated. Of 3593 included patients, 1146 (31.9%) were female. Female patients were older (61.0 vs. 56.4 years; P < 0.001), had more comorbidities (hypertension, diabetes, and obesity), more episodes of arrhythmias per month (6.9 vs. 6.2; P < 0.001), and a higher average EHRA score (2.6 vs. 2.4; P < 0.001). The duration of the procedure was shorter in females (160.1 min vs. 167.9 min; P < 0.001), irrespective of additional ablation lesions added to pulmonary vein isolation. Overall cardiovascular complications were more frequent in women than in men (5.7% vs. 3.4%; P < 0.001). Furthermore, cardiac perforations (3.8% vs. 1.3%; P = 0.011) and neurological complications (2.2% vs. 0.3%; P = 0.004) were found in females in less experienced centres than in experienced ones. On a final note, at 12 months, AF recurrence rate was similar in females and males (34.4% vs. 34.2%; P = 0.897), but more females were still on antiarrhythmic drugs (50.6% vs. 44.1%; P < 0.001) when compared with men. CONCLUSION: Females underwent CA procedures for AF less frequently than males throughout Europe, despite more recurrent symptoms. With the same success rate, severe acute complications remained considerable in females, especially in less experienced centres.
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