• Something wrong with this record ?

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis

S. Borna, A. Drobek, J. Kralova, D. Glatzova, I. Splichalova, M. Fabisik, J. Pokorna, T. Skopcova, P. Angelisova, V. Kanderova, J. Starkova, P. Stanek, OV. Matveichuk, N. Pavliuchenko, K. Kwiatkowska, MB. Protty, MG. Tomlinson, M. Alberich-Jorda,...

. 2020 ; 24 (2) : 1980-1992. [pub] 20191217

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc21020822

Grant support
G0400247 Medical Research Council - United Kingdom

WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6-RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non-haematopoietic cells. However, its physiological function has been unknown. Here, we show that WBP1L negatively regulates signalling through a critical chemokine receptor CXCR4 in multiple leucocyte subsets and cell lines. We also show that WBP1L interacts with NEDD4-family ubiquitin ligases and regulates CXCR4 ubiquitination and expression. Moreover, analysis of Wbp1l-deficient mice revealed alterations in B cell development and enhanced efficiency of bone marrow cell transplantation. Collectively, our data show that WBP1L is a novel regulator of CXCR4 signalling and haematopoiesis.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21020822
003      
CZ-PrNML
005      
20210830102448.0
007      
ta
008      
210728s2020 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/jcmm.14895 $2 doi
035    __
$a (PubMed)31845480
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Borna, Simon $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Science, Charles University, Prague, Czech Republic
245    10
$a Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis / $c S. Borna, A. Drobek, J. Kralova, D. Glatzova, I. Splichalova, M. Fabisik, J. Pokorna, T. Skopcova, P. Angelisova, V. Kanderova, J. Starkova, P. Stanek, OV. Matveichuk, N. Pavliuchenko, K. Kwiatkowska, MB. Protty, MG. Tomlinson, M. Alberich-Jorda, V. Korinek, T. Brdicka
520    9_
$a WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6-RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non-haematopoietic cells. However, its physiological function has been unknown. Here, we show that WBP1L negatively regulates signalling through a critical chemokine receptor CXCR4 in multiple leucocyte subsets and cell lines. We also show that WBP1L interacts with NEDD4-family ubiquitin ligases and regulates CXCR4 ubiquitination and expression. Moreover, analysis of Wbp1l-deficient mice revealed alterations in B cell development and enhanced efficiency of bone marrow cell transplantation. Collectively, our data show that WBP1L is a novel regulator of CXCR4 signalling and haematopoiesis.
650    _2
$a adaptorové proteiny signální transdukční $x metabolismus $7 D048868
650    _2
$a zvířata $7 D000818
650    _2
$a zárodečné buňky $x metabolismus $7 D005854
650    _2
$a glykoproteiny $x metabolismus $7 D006023
650    _2
$a HEK293 buňky $7 D057809
650    12
$a hematopoéza $7 D006410
650    _2
$a hematopoetické kmenové buňky $x metabolismus $7 D006412
650    _2
$a homeostáza $7 D006706
650    _2
$a lidé $7 D006801
650    _2
$a lipoylace $7 D054878
650    _2
$a membránové proteiny $x genetika $x metabolismus $7 D008565
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a vazba proteinů $7 D011485
650    _2
$a malá interferující RNA $x metabolismus $7 D034741
650    _2
$a receptory CXCR4 $x metabolismus $7 D019718
650    12
$a signální transdukce $7 D015398
650    _2
$a ubikvitinligasy $x metabolismus $7 D044767
650    _2
$a ubikvitinace $7 D054875
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Drobek, Ales $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Kralova, Jarmila $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Glatzova, Daniela $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Science, Charles University, Prague, Czech Republic $u Department of Biophysical Chemistry, J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Splichalova, Iva $u Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Fabisik, Matej $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Science, Charles University, Prague, Czech Republic
700    1_
$a Pokorna, Jana $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Skopcova, Tereza $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Angelisova, Pavla $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Kanderova, Veronika $u CLIP - Childhood Leukaemia Investigation Prague and Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Starkova, Julia $u CLIP - Childhood Leukaemia Investigation Prague and Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Stanek, Petr $u Second Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Matveichuk, Orest V $u Laboratory of Molecular Membrane Biology, Nencki Institute of Experimental Biology, Warsaw, Poland
700    1_
$a Pavliuchenko, Nataliia $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Science, Charles University, Prague, Czech Republic
700    1_
$a Kwiatkowska, Katarzyna $u Laboratory of Molecular Membrane Biology, Nencki Institute of Experimental Biology, Warsaw, Poland
700    1_
$a Protty, Majd B $u Institute of Biomedical Research, University of Birmingham, Birmingham, UK
700    1_
$a Tomlinson, Michael G $u School of Biosciences, University of Birmingham, Birmingham, UK
700    1_
$a Alberich-Jorda, Meritxell $u Laboratory of Hematooncology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Korinek, Vladimir $u Laboratory of Cell and Developmental Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Brdicka, Tomas $u Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
773    0_
$w MED00006785 $t Journal of cellular and molecular medicine $x 1582-4934 $g Roč. 24, č. 2 (2020), s. 1980-1992
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31845480 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830102449 $b ABA008
999    __
$a ok $b bmc $g 1691413 $s 1141268
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 24 $c 2 $d 1980-1992 $e 20191217 $i 1582-4934 $m Journal of cellular and molecular medicine $n J Cell Mol Med $x MED00006785
GRA    __
$a G0400247 $p Medical Research Council $2 United Kingdom
LZP    __
$a Pubmed-20210728

Find record

Citation metrics

Archiving options