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Intra-Tumour Heterogeneity Is One of the Main Sources of Inter-Observer Variation in Scoring Stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer
D. Kilmartin, M. O'Loughlin, X. Andreu, Z. Bagó-Horváth, S. Bianchi, E. Chmielik, G. Cserni, P. Figueiredo, G. Floris, MP. Foschini, A. Kovács, P. Heikkilä, J. Kulka, AV. Laenkholm, I. Liepniece-Karele, C. Marchiò, E. Provenzano, P. Regitnig, A....
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 2009
PubMed Central
od 2009
Europe PubMed Central
od 2009
ProQuest Central
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Open Access Digital Library
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2009
PubMed
34503219
DOI
10.3390/cancers13174410
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Stromal tumour infiltrating lymphocytes (sTILs) are a strong prognostic marker in triple negative breast cancer (TNBC). Consistency scoring sTILs is good and was excellent when an internet-based scoring aid developed by the TIL-WG was used to score cases in a reproducibility study. This study aimed to evaluate the reproducibility of sTILs assessment using this scoring aid in cases from routine practice and to explore the potential of the tool to overcome variability in scoring. Twenty-three breast pathologists scored sTILs in digitized slides of 49 TNBC biopsies using the scoring aid. Subsequently, fields of view (FOV) from each case were selected by one pathologist and scored by the group using the tool. Inter-observer agreement was good for absolute sTILs (ICC 0.634, 95% CI 0.539-0.735, p < 0.001) but was poor to fair using binary cutpoints. sTILs heterogeneity was the main contributor to disagreement. When pathologists scored the same FOV from each case, inter-observer agreement was excellent for absolute sTILs (ICC 0.798, 95% CI 0.727-0.864, p < 0.001) and good for the 20% (ICC 0.657, 95% CI 0.561-0.756, p < 0.001) and 40% (ICC 0.644, 95% CI 0.546-0.745, p < 0.001) cutpoints. However, there was a wide range of scores for many cases. Reproducibility scoring sTILs is good when the scoring aid is used. Heterogeneity is the main contributor to variance and will need to be overcome for analytic validity to be achieved.
2nd Department of Pathology Semmelweis University Budapest Üllői út 93 1091 Budapest Hungary
Department of Clinical Pathology Sahlgrenska University Hospital 41345 Gothenburg Sweden
Department of Medical Sciences University of Turin 10126 Turin Italy
Department of Pathology Bács Kiskun County Teaching Hospital 6000 Kecskemét Hungary
Department of Pathology Helsinki University Central Hospital 00029 Helsinki Finland
Department of Pathology Klinikum Donaustadt 1090 Vienna Austria
Department of Pathology Medical University of Vienna Währinger Gürtel 18 20 1090 Vienna Austria
Department of Pathology Riga Stradins University LV 1007 Riga Latvia
Department of Pathology School of Medicine University of Patras 26504 Rion Greece
Department of Surgical Pathology Zealand University Hospital 4000 Roskilde Denmark
Diagnostic and Research Institute of Pathology Medical University of Graz 8010 Graz Austria
Laboratório de Anatomia Patológica Instituto Politécnico de Coimbra 3000 075 Coimbra Portugal
National Institute for Health Research Cambridge Biomedical Research Centre Cambridge CB2 0QQ UK
Pathology Department Herlev University Hospital DK 2730 Herlev Denmark
School of Medicine University College Dublin D04 V1W8 Dublin Ireland
Unit of Pathology Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Italy
Citace poskytuje Crossref.org
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