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Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
M. Dejmek, E. Konkoľová, L. Eyer, P. Straková, P. Svoboda, M. Šála, K. Krejčová, D. Růžek, E. Boura, R. Nencka
Language English Country Switzerland
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
CZ.02.1.01/0.0/0.0/16_019/0000729
European Regional Development Fund
NU20-05-00472
Ministerstvo Zdravotnictví Ceské Republiky
RVO: 61388963
Akademie Věd České Republiky
LTAUSA18016
Ministerstvo Školství, Mládeže a Tělovýchovy
NA
Gilead Sciences
NLK
Directory of Open Access Journals
from 2009
Free Medical Journals
from 2009
PubMed Central
from 2009
Europe PubMed Central
from 2009
ProQuest Central
from 2009-01-01
Open Access Digital Library
from 2009-01-01
Open Access Digital Library
from 2009-01-01
Health & Medicine (ProQuest)
from 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2009
PubMed
34452451
DOI
10.3390/v13081585
Knihovny.cz E-resources
- MeSH
- Adenosine Monophosphate analogs & derivatives pharmacology MeSH
- Alanine analogs & derivatives pharmacology MeSH
- Antiviral Agents pharmacology MeSH
- Benzothiazoles pharmacology MeSH
- Cell Line MeSH
- Enzyme Inhibitors pharmacology MeSH
- Coronavirus RNA-Dependent RNA Polymerase antagonists & inhibitors MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Virus Replication drug effects MeSH
- SARS-CoV-2 drug effects enzymology physiology MeSH
- Cell Survival drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding disease. With respect to its essential role in the replication of viral RNA, RNA-dependent RNA polymerase (RdRp) is one of the prime targets. HeE1-2Tyr and related derivatives were originally discovered as inhibitors of the RdRp of flaviviruses. Here, we present that these pyridobenzothiazole derivatives also significantly inhibit SARS-CoV-2 RdRp, as demonstrated using both polymerase- and cell-based antiviral assays.
References provided by Crossref.org
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