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Je něco špatně v tomto záznamu ?
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
M. Dejmek, E. Konkoľová, L. Eyer, P. Straková, P. Svoboda, M. Šála, K. Krejčová, D. Růžek, E. Boura, R. Nencka
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
CZ.02.1.01/0.0/0.0/16_019/0000729
European Regional Development Fund
NU20-05-00472
Ministerstvo Zdravotnictví Ceské Republiky
RVO: 61388963
Akademie Věd České Republiky
LTAUSA18016
Ministerstvo Školství, Mládeže a Tělovýchovy
NA
Gilead Sciences
NLK
Directory of Open Access Journals
od 2009
Free Medical Journals
od 2009
PubMed Central
od 2009
Europe PubMed Central
od 2009
ProQuest Central
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Health & Medicine (ProQuest)
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2009
PubMed
34452451
DOI
10.3390/v13081585
Knihovny.cz E-zdroje
- MeSH
- adenosinmonofosfát analogy a deriváty farmakologie MeSH
- alanin analogy a deriváty farmakologie MeSH
- antivirové látky farmakologie MeSH
- benzothiazoly farmakologie MeSH
- buněčné linie MeSH
- inhibitory enzymů farmakologie MeSH
- koronavirová RNA-replikasa antagonisté a inhibitory MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- replikace viru účinky léků MeSH
- SARS-CoV-2 účinky léků enzymologie fyziologie MeSH
- viabilita buněk účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding disease. With respect to its essential role in the replication of viral RNA, RNA-dependent RNA polymerase (RdRp) is one of the prime targets. HeE1-2Tyr and related derivatives were originally discovered as inhibitors of the RdRp of flaviviruses. Here, we present that these pyridobenzothiazole derivatives also significantly inhibit SARS-CoV-2 RdRp, as demonstrated using both polymerase- and cell-based antiviral assays.
Citace poskytuje Crossref.org
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