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Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank
AG. Mathioudakis, M. Miligkos, C. Boccabella, GS. Alimani, A. Custovic, A. Deschildre, FM. Ducharme, O. Kalayci, C. Murray, AN. Garcia, W. Phipatanakul, D. Price, A. Sheikh, IO. Agache, L. Bacharier, A. Beloukas, A. Bentley, M. Bonini, JA....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
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od 2011
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od 2011
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- MeSH
- bronchiální astma * farmakoterapie MeSH
- dítě MeSH
- hospitalizace MeSH
- lidé MeSH
- systematický přehled jako téma MeSH
- výzkumný projekt MeSH
- zkreslení výsledků (epidemiologie) MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted. METHODS AND ANALYSIS: Standard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively.Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence. ETHICS AND DISSEMINATION: Ethics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank. PROSPERO REGISTRATION NUMBERS: CRD42020132990, CRD42020171624.
Allergy and Asthma Global Patient Platform Virginia Virginia USA
Allergy and Asthma VN Chennai India
Allergy and Clinical Immunology Transylvania University Brasov Romania
Allergy Asthma and Immunology Penn State University Hershey Pennsylvania USA
Allergy Center CUF Infante Santo Hospital Lisbon Portugal
Allergy Center Hospital CUF Descobertas Lisboa Portugal
Athens Breath Centre Athens Greece
Centre for Genomics and Child Health Blizard Institute Queen Mary University of London London UK
Centre of Academic Primary Care University of Aberdeen Aberdeen UK
Department of Allergy University of Helsinki Helsinki Uusimaa Finland
Department of Biomedical Sciences University of West Attica Egaleo Attica Greece
Department of Child Health University of Aberdeen Aberdeen Aberdeen UK
Department of Paediatrics Faculty of Medicine The Chinese University of Hong Kong Sha Tin Hong Kong
Department of Paediatrics Imperial College London London UK
Department of Paediatrics University of Turku Turku Finland
Department of Pediatric Pulmonology and Allergy Medical University of Warsaw Warszawa Poland
Department of Pediatrics Pontifical Universidad Catolica de Chile Santiago Chile
Department of Social Medicine Faculty of Medicine University of Crete Rethimno Greece
Department of Women's and Children's Health Karolinska Institute Stockholm Stockholm Sweden
Division of Infection Immunity and Respiratory Medicine The University of Manchester Manchester UK
Family Physician Airways Group of Canada University of Toronto Toronto Ontario Canada
Institute of Infection and Global Health University of Liverpool Liverpool UK
National Heart and Lung Institute Imperial College London London UK
NIHR Biomedical Research Centre University Hospital Southampton NHS Foundation Trust Southampton UK
North West Lung Centre Manchester University NHS Foundation Trust Manchester UK
Observational and Pragmatic Research Institute Singapore
Paediatric Department Motol University Hospital Praha Czech Republic
Pediatric Allergy and Asthma Unit Hacettepe Universitesi Ankara Turkey
Pediatric Allergy and Immunology Children's Hospital Boston Boston Massachusetts USA
Pediatric Allergy and Immunology Unit Ain Shams University Cairo Egypt
Pediatrics University of Montreal Montreal Quebec Canada
The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport Isle of Wight UK
Unit on Child and Adolescent Health Medical Reaserch Council Cape Town South Africa
Citace poskytuje Crossref.org
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