Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties

J. Chai, X. Chen, T. Ye, B. Zeng, Q. Zeng, J. Wu, B. Kascakova, LA. Martins, T. Prudnikova, IK. Smatanova, M. Kotsyfakis, X. Xu

. 2021 ; 10 (-) : . [pub] 20210420

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21025842

Grantová podpora
31772476 National Natural Science Foundation of China
31861143050 National Natural Science Foundation of China
31911530077 National Natural Science Foundation of China
82070038 National Natural Science Foundation of China

Antimicrobial peptides form part of the innate immune response and play a vital role in host defense against pathogens. Here we report a new antimicrobial peptide belonging to the cathelicidin family, cathelicidin-MH (cath-MH), from the skin of Microhyla heymonsivogt frog. Cath-MH has a single α-helical structure in membrane-mimetic environments and is antimicrobial against fungi and bacteria, especially Gram-negative bacteria. In contrast to other cathelicidins, cath-MH suppresses coagulation by affecting the enzymatic activities of tissue plasminogen activator, plasmin, β-tryptase, elastase, thrombin, and chymase. Cath-MH protects against lipopolysaccharide (LPS)- and cecal ligation and puncture-induced sepsis, effectively ameliorating multiorgan pathology and inflammatory cytokine through its antimicrobial, LPS-neutralizing, coagulation suppressing effects as well as suppression of MAPK signaling. Taken together, these data suggest that cath-MH is an attractive candidate therapeutic agent for the treatment of septic shock.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21025842
003      
CZ-PrNML
005      
20211026133442.0
007      
ta
008      
211013s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.7554/eLife.64411 $2 doi
035    __
$a (PubMed)33875135
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Chai, Jinwei $u Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China $u Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
245    10
$a Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties / $c J. Chai, X. Chen, T. Ye, B. Zeng, Q. Zeng, J. Wu, B. Kascakova, LA. Martins, T. Prudnikova, IK. Smatanova, M. Kotsyfakis, X. Xu
520    9_
$a Antimicrobial peptides form part of the innate immune response and play a vital role in host defense against pathogens. Here we report a new antimicrobial peptide belonging to the cathelicidin family, cathelicidin-MH (cath-MH), from the skin of Microhyla heymonsivogt frog. Cath-MH has a single α-helical structure in membrane-mimetic environments and is antimicrobial against fungi and bacteria, especially Gram-negative bacteria. In contrast to other cathelicidins, cath-MH suppresses coagulation by affecting the enzymatic activities of tissue plasminogen activator, plasmin, β-tryptase, elastase, thrombin, and chymase. Cath-MH protects against lipopolysaccharide (LPS)- and cecal ligation and puncture-induced sepsis, effectively ameliorating multiorgan pathology and inflammatory cytokine through its antimicrobial, LPS-neutralizing, coagulation suppressing effects as well as suppression of MAPK signaling. Taken together, these data suggest that cath-MH is an attractive candidate therapeutic agent for the treatment of septic shock.
650    _2
$a sekvence aminokyselin $7 D000595
650    _2
$a proteiny obojživelníků $x chemie $x farmakologie $7 D029845
650    _2
$a zvířata $7 D000818
650    _2
$a antiinfekční látky $x chemie $x farmakologie $7 D000890
650    12
$a žáby $7 D001001
650    _2
$a sekvence nukleotidů $7 D001483
650    _2
$a kathelicidiny $x chemie $x farmakologie $7 D054804
650    _2
$a fylogeneze $7 D010802
650    _2
$a sepse $x farmakoterapie $7 D018805
650    _2
$a sekvenční seřazení $7 D016415
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Chen, Xin $u Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China
700    1_
$a Ye, Tiaofei $u Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China $u Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
700    1_
$a Zeng, Baishuang $u Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
700    1_
$a Zeng, Qingye $u Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
700    1_
$a Wu, Jiena $u Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
700    1_
$a Kascakova, Barbora $u Faculty of Science, University of South Bohemia in Ceske Budejovice, Branisovska, Czech Republic
700    1_
$a Martins, Larissa Almeida $u Institute of Parasitology, Biology Center of the Czech Academy of Sciences, Branisovska, Czech Republic
700    1_
$a Prudnikova, Tatyana $u Faculty of Science, University of South Bohemia in Ceske Budejovice, Branisovska, Czech Republic
700    1_
$a Smatanova, Ivana Kuta $u Faculty of Science, University of South Bohemia in Ceske Budejovice, Branisovska, Czech Republic
700    1_
$a Kotsyfakis, Michail $u Institute of Parasitology, Biology Center of the Czech Academy of Sciences, Branisovska, Czech Republic
700    1_
$a Xu, Xueqing $u Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
773    0_
$w MED00188753 $t eLife $x 2050-084X $g Roč. 10, č. - (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33875135 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20211026133448 $b ABA008
999    __
$a ok $b bmc $g 1714755 $s 1146349
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 10 $c - $e 20210420 $i 2050-084X $m eLife $n eLife $x MED00188753
GRA    __
$a 31772476 $p National Natural Science Foundation of China
GRA    __
$a 31861143050 $p National Natural Science Foundation of China
GRA    __
$a 31911530077 $p National Natural Science Foundation of China
GRA    __
$a 82070038 $p National Natural Science Foundation of China
LZP    __
$a Pubmed-20211013

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace