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Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly
J. Soukup, H. Hornychova, M. Manethova, K. Michalova, L. Michnova, L. Popovska, V. Skarkova, T. Cesak, D. Netuka, A. Ryska, J. Cap, V. Hána, V. Hána, M. Kršek, E. Dvořáková, M. Krčma, I. Lazurova, V. Olšovská, K. Starý, P. Vaňuga, F. Gabalec
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NV19-01-00435
Ministerstvo Zdravotnictví Ceské Republiky
NLK
Directory of Open Access Journals
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PubMed Central
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PubMed
33491286
DOI
10.1111/jcmm.16173
Knihovny.cz E-resources
- MeSH
- Acromegaly complications genetics metabolism MeSH
- Biomarkers MeSH
- Adult MeSH
- Immunohistochemistry MeSH
- Cadherins genetics MeSH
- Clinical Decision-Making MeSH
- Combined Modality Therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Disease Management MeSH
- Young Adult MeSH
- Pituitary Neoplasms diagnosis etiology therapy MeSH
- Prognosis MeSH
- Protein Isoforms MeSH
- Receptors, Somatostatin genetics metabolism MeSH
- Gene Expression Regulation * MeSH
- ROC Curve MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
In somatotroph pituitary tumours, somatostatin analogue (SSA) therapy outcomes vary throughout the studies. We performed an analysis of cohort of patients with acromegaly from the Czech registry to identify new prognostic and predictive factors. Clinical data of patients were collected, and complex immunohistochemical assessment of tumour samples was performed (SSTR1-5, dopamine D2 receptor, E-cadherin, AIP). The study included 110 patients. In 31, SSA treatment outcome was evaluated. Sparsely granulated tumours (SGST) differed from the other subtypes in expression of SSTR2A, SSTR3, SSTR5 and E-cadherin and occurred more often in young. No other clinical differences were observed. Trouillas grading system showed association with age, tumour size and SSTR2A expression. Factors significantly associated with SSA treatment outcome included age, IGF1 levels, tumour size and expression of E-cadherin and SSTR2A. In the group of SGST, poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A and higher Ki67. We observed no relationship with expression of other proteins including AIP. No predictive value of E-cadherin was observed when tumour subtype was considered. Multiple additional factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly.
1st Internal Clinic Louis Pasteur University Hospital Kosice Slovakia
Bioptical Laboratory Ltd Plzen Czech Republic
Department of Pathology Faculty of Medicine Charles University Plzen Czech Republic
Department of Pathology Military University Hospital Prague Prague Czech Republic
National Institute of Endocrinology and Diabetology Lubochňa Slovakia
References provided by Crossref.org
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- $a Soukup, Jiri $u The Fingerland Department of Pathology, Faculty of Medicine, University Hospital, Charles University, Hradec Kralove, Czech Republic
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- $a In somatotroph pituitary tumours, somatostatin analogue (SSA) therapy outcomes vary throughout the studies. We performed an analysis of cohort of patients with acromegaly from the Czech registry to identify new prognostic and predictive factors. Clinical data of patients were collected, and complex immunohistochemical assessment of tumour samples was performed (SSTR1-5, dopamine D2 receptor, E-cadherin, AIP). The study included 110 patients. In 31, SSA treatment outcome was evaluated. Sparsely granulated tumours (SGST) differed from the other subtypes in expression of SSTR2A, SSTR3, SSTR5 and E-cadherin and occurred more often in young. No other clinical differences were observed. Trouillas grading system showed association with age, tumour size and SSTR2A expression. Factors significantly associated with SSA treatment outcome included age, IGF1 levels, tumour size and expression of E-cadherin and SSTR2A. In the group of SGST, poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A and higher Ki67. We observed no relationship with expression of other proteins including AIP. No predictive value of E-cadherin was observed when tumour subtype was considered. Multiple additional factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly.
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