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Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation)

M. Čoma, L. Fröhlichová, L. Urban, R. Zajíček, T. Urban, P. Szabo, Š. Novák, V. Fetissov, B. Dvořánková, K. Smetana, P. Gál

. 2021 ; 22 (2) : . [pub] 20210118

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc21026189

Grant support
APVV-16-0207 and APVV-14-0731 Agentúra na Podporu Výskumu a Vývoja
VEGA-1/0561/18 Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
PROGRES Q28 and Q37 Univerzita Karlova v Praze
CZ.02.1.01/0.0/0.0/16_019/0000785 and ITMS2014+ 313011D103 European Regional Development Fund
CA18103 European Cooperation in Science and Technology

Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in progressive deterioration of the structure and function of organs. It can also be seen during tumor growth and other fibroproliferative disorders. These processes result from a wide spectrum of cross-talks between mesenchymal, epithelial and inflammatory/immune cells that have not yet been fully understood. In the present review, we aimed to describe the molecular features of fibroblasts and their interactions with immune and epithelial cells and extracellular matrix. We also compared different types of fibroblasts and their roles in skin repair and regeneration following burn injury. In summary, here we briefly review molecular changes underlying hypertrophic scarring following burns throughout all basic wound healing stages, i.e. during inflammation, proliferation and maturation.

References provided by Crossref.org

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